ChemicalBook > CAS DataBase List > 4-CHLORO-3-METHOXYBENZOIC ACID

4-CHLORO-3-METHOXYBENZOIC ACID

Product Name
4-CHLORO-3-METHOXYBENZOIC ACID
CAS No.
85740-98-3
Chemical Name
4-CHLORO-3-METHOXYBENZOIC ACID
Synonyms
TIMTEC-BB SBB008504;4-Chloro-m-anisic Acid;4-Chloro-3-Methoxybenzoic;3-methoxy-4-chlorobenzoic acid;4-CHLORO-3-METHOXYBENZOIC ACID;Benzoic acid,4-chloro-3-methoxy-;4-Chloro-3-methoxybenzoic acid, >=98%;4-CHLORO-3-METHOXYBENZOIC ACID ---POWDER---
CBNumber
CB2240372
Molecular Formula
C8H7ClO3
Formula Weight
186.59
MOL File
85740-98-3.mol
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4-CHLORO-3-METHOXYBENZOIC ACID Property

Melting point:
217.0 to 221.0 °C
Boiling point:
325.4±22.0 °C(Predicted)
Density 
1.352±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
powder to crystal
pka
3.85±0.10(Predicted)
color 
White to Almost white
CAS DataBase Reference
85740-98-3(CAS DataBase Reference)
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Safety

Hazard Codes 
T,N
Risk Statements 
36/37/38-50-25
Safety Statements 
26-36/37/39-61-45
RIDADR 
3077
WGK Germany 
3
HazardClass 
9
PackingGroup 
Ⅲ
HS Code 
2918999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
ANV00031
Product name
4-Chloro-3-methoxybenzoic acid
Purity
AldrichCPR
Packaging
1G
Price
$172
Updated
2023/01/07
TCI Chemical
Product number
C3304
Product name
4-Chloro-3-methoxybenzoic Acid
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$39
Updated
2025/07/31
TCI Chemical
Product number
C3304
Product name
4-Chloro-3-methoxybenzoic Acid
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$112
Updated
2025/07/31
Biosynth Carbosynth
Product number
FC55332
Product name
4-Chloro-3-methoxybenzoic acid
Packaging
50g
Price
$125
Updated
2021/12/16
SynQuest Laboratories
Product number
2621-5-0A
Product name
4-Chloro-3-methoxybenzoic acid
Packaging
5G
Price
$141
Updated
2021/12/16
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4-CHLORO-3-METHOXYBENZOIC ACID Chemical Properties,Usage,Production

Uses

4-Chloro-3-methoxybenzoic acid can be used to synthesize specific drug molecules, such as a key intermediate for the antiarrhythmic drug amiodarone.

Synthesis

73909-16-7

85740-98-3

B. Synthesis of 4-chloro-3-methoxybenzoic acid (0200) To crude 1-chloro-2-methoxy-4-methylbenzene (7.8 g, 50 mmol) was added an aqueous solution of potassium permanganate (KMnO4, 19.8 g, 125 mmol) (300 mL). The reaction mixture was stirred vigorously under reflux conditions for 17 h. After completion of the reaction, the filter was passed through diatomaceous earth and the filter cake was washed with hot water (200 mL). The clarified filtrate was washed with ether (2 x 150 mL) and then acidified with concentrated hydrochloric acid (HCl) to pH < 2. After addition of concentrated hydrochloric acid (9 mL), the precipitate was collected by filtration to give pure white solid 4-chloro-3-methoxybenzoic acid (5.36 g, 58% yield). Electrospray mass spectrometry (ES-MS) showed (M + H)+ peak located at m/z = 187.

References

[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 23, p. 4408 - 4414
[2] European Journal of Medicinal Chemistry, 2011, vol. 46, # 12, p. 5754 - 5762
[3] Archiv der Pharmazie, 2011, vol. 344, # 11, p. 745 - 754
[4] Chemical Biology and Drug Design, 2013, vol. 82, # 3, p. 336 - 347
[5] European Journal of Medicinal Chemistry, 2013, vol. 65, p. 315 - 322

4-CHLORO-3-METHOXYBENZOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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4-CHLORO-3-METHOXYBENZOIC ACID Suppliers

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View Lastest Price from 4-CHLORO-3-METHOXYBENZOIC ACID manufacturers

Career Henan Chemical Co
Product
4-CHLORO-3-METHOXYBENZOIC ACID 85740-98-3
Price
US $6.68/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg-1000kg
Release date
2020-01-08

85740-98-3, 4-CHLORO-3-METHOXYBENZOIC ACIDRelated Search:

3-CHLORO-4-METHOXYBENZOIC ACID METHYL ESTER,3-CHLORO-4-METHOXYBENZOIC ACID METHYL ESTER 97% Dicamba potassium salt 5-Chloro-2-methoxybenzoic acid methyl ester~Methyl 5-chloro-o-anisate,5-CHLORO-2-METHOXYBENZOIC ACID METHYL ESTER N-ACETYL-4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID, METHYL ESTER,4-ACETAMIDO-5-CHLORO-2-METHOXYBENZOIC ACID METHYL ESTER 2-chloro-6-methoxybenzoic acid 4-CHLORO-3-(TRIFLUOROMETHYL)BENZOIC ACID 4-AMINO-5-CHLORO-2-METHOXYBENZOIC ACID,4-AMINO-5-CHLORO-3-METHOXYBENZOIC ACID Dicamba 2-CHLORO-5-METHOXYBENZOIC ACID,2-Chloro-5-methoxybenzoic acid 98% 4-ACETAMIDO-5-CHLORO-2-METHOXYBENZOIC ACID,95% MIN(HPLC) Dicamba sodium salt 2-Chloro-4-methoxybenzoic acid 4-CHLORO-2-METHOXYBENZOIC ACID / 4-CHLORO-O-ANISIC ACID,4-Chloro-2-Methoxybenzoic Acid 2-Methoxy-4-Chlorobenzoic Acid,4-CHLORO-2-METHOXYBENZOIC ACID Methyl 4-chloro-2-methoxybenzoate 5-Bromo-4-chloro-2-methoxybenzoic acid 3-(CHLOROSULFONYL)-4-METHOXYBENZOIC ACID 5-Chloro-2-methoxybenzoic acid 3-CHLORO-4-METHOXYBENZOIC ACID,3-CHLORO-4-METHOXYBENZOIC ACID 97%,3-Chloro-4-methoxybenzoic acid, 98+%

  • TIMTEC-BB SBB008504
  • 4-CHLORO-3-METHOXYBENZOIC ACID
  • 4-CHLORO-3-METHOXYBENZOIC ACID ---POWDER---
  • Benzoic acid,4-chloro-3-methoxy-
  • 4-Chloro-3-Methoxybenzoic
  • 4-Chloro-3-methoxybenzoic acid, >=98%
  • 4-Chloro-m-anisic Acid
  • 3-methoxy-4-chlorobenzoic acid
  • 85740-98-3
  • C8H7O3Cl
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Benzoic acid
  • Acids & Esters
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Chlorine Compounds