2-Chloro-4-methoxybenzoic acid
- Product Name
- 2-Chloro-4-methoxybenzoic acid
- CAS No.
- 21971-21-1
- Chemical Name
- 2-Chloro-4-methoxybenzoic acid
- Synonyms
- MIF-IN-2 Impurity 3;Dotinurad Impurity 162;2-Chloro-p-anisic Acid;2-Chloro-4-metxybenzoic acid;2-Chloro-4-methoxybenzoic acid;2-Chloro-4-methoxybenzoicacid,98%;Benzoic acid, 2-chloro-4-methoxy-;2-CHLORO-4-(METHYLOXY)BENZOIC ACID;2-Chloro-4-methoxybenzoic Acid >2-Chloro-4-Methoxybenzoic acid, 97%+
- CBNumber
- CB0947022
- Molecular Formula
- C8H7ClO3
- Formula Weight
- 186.59
- MOL File
- 21971-21-1.mol
2-Chloro-4-methoxybenzoic acid Property
- Melting point:
- 210.0 to 214.0 °C
- Boiling point:
- 303.0±22.0 °C(Predicted)
- Density
- 1.352±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly, Sonicated)
- form
- Solid
- pka
- 3.32±0.25(Predicted)
- color
- White to Off-White
- CAS DataBase Reference
- 21971-21-1
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C3077
- Product name
- 2-Chloro-4-methoxybenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- C3077
- Product name
- 2-Chloro-4-methoxybenzoic Acid
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $106
- Updated
- 2025/07/31
- Product number
- C367880
- Product name
- 2-Chloro-4-methoxybenzoic Acid
- Packaging
- 2.5g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- HCH0027735
- Product name
- 2-CHLORO-4-METHOXYBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $852.55
- Updated
- 2021/12/16
- Product number
- HCH0027735
- Product name
- 2-CHLORO-4-METHOXYBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 2.5G
- Price
- $1227.82
- Updated
- 2021/12/16
2-Chloro-4-methoxybenzoic acid Chemical Properties,Usage,Production
Chemical Properties
White to pale yellow powder
Uses
2-Chloro-4-Methoxybenzoic Acid has been used as a reactant for the preparation of benzamidochromenone carboxylic acids as selective agonists for orphan G protein-coupled receptor GPR35
Synthesis
104253-45-4
21971-21-1
2-Chloro-4-methoxybenzoic acid was synthesized as follows: methyl 2-chloro-4-methoxybenzoate (1.1 g) was dissolved in a mixed solvent of THF/MeOH/water (12 mL/3 mL/3 mL) at room temperature. Subsequently, LiOH (461 mg) dissolved in water was added. After the reaction was carried out for 2 h, the pH of the reaction mixture was adjusted to 4 with 1 N HCl. Next, the reaction mixture was partitioned between ethyl acetate and water. The organic layer was separated, washed with brine and dried over MgSO4. Finally, the resulting solid was ground in ether to give 1.0 g (98% yield) of 2-chloro-4-methoxybenzoic acid. Mass spectrometry (MS) analysis showed 187 (MH+) and high performance liquid chromatography (HPLC) retention time (tR): 2.04 min.
References
[1] Patent: US2004/102435, 2004, A1
2-Chloro-4-methoxybenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-4-methoxybenzoic acid manufacturers
- Product
- 2-Chloro-4-methoxybenzoic acid 21971-21-1
- Price
- US $2.20-8.80/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-17
- Product
- 2-Chloro-4-methoxybenzoic acid 21971-21-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-10
- Product
- 2-Chloro-4-methoxybenzoic acid 21971-21-1
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-09