ChemicalBook > CAS DataBase List > 3-[7-(2,4-DIMETHOXYPHENYL)-2,3,6,7-TETRAHYDRO-1,4-THIAZEPIN-5-YL]-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE
3-[7-(2,4-DIMETHOXYPHENYL)-2,3,6,7-TETRAHYDRO-1,4-THIAZEPIN-5-YL]-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE
- Product Name
- 3-[7-(2,4-DIMETHOXYPHENYL)-2,3,6,7-TETRAHYDRO-1,4-THIAZEPIN-5-YL]-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE
- CAS No.
- 257292-29-8
- Chemical Name
- 3-[7-(2,4-DIMETHOXYPHENYL)-2,3,6,7-TETRAHYDRO-1,4-THIAZEPIN-5-YL]-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE
- Synonyms
- KF 38789;inhibit,Inhibitor,PSGL-1,Cell adhesion,P-selectin Inhibitor,KF-38789,KF38789,Inflammation;3-[7-(2,4-DIMETHOXYPHENYL)-2,3,6,7-TETRAHYDRO-1,4-THIAZEPIN-5-YL]-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE;2H-Pyran-2-one, 3-[7-(2,4-dimethoxyphenyl)-2,3,6,7-tetrahydro-1,4-thiazepin-5-yl]-4-hydroxy-6-methyl-
- CBNumber
- CB22446286
- Molecular Formula
- C19H21NO5S
- Formula Weight
- 375.44
- MOL File
- 257292-29-8.mol
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3-[7-(2,4-DIMETHOXYPHENYL)-2,3,6,7-TETRAHYDRO-1,4-THIAZEPIN-5-YL]-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE Property
- storage temp.
- Desiccate at +4°C
- solubility
- <37.54mg/ml in DMSO
- form
- Solid
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
Tocris
- Product number
- 2748
- Product name
- KF38789
- Purity
- ≥97%(HPLC)
- Packaging
- 10
- Price
- $223
- Updated
- 2021/12/16
TRC
- Product number
- K478120
- Product name
- KF38789
- Packaging
- 1mg
- Price
- $105
- Updated
- 2021/12/16
Usbiological
- Product number
- 453034
- Product name
- KF 38789
- Packaging
- 1mg
- Price
- $382
- Updated
- 2021/12/16
Usbiological
- Product number
- 255594
- Product name
- KF 38789
- Packaging
- 10mg
- Price
- $466
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- INB0001225
- Product name
- KF 38789
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $739.2
- Updated
- 2021/12/16
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3-[7-(2,4-DIMETHOXYPHENYL)-2,3,6,7-TETRAHYDRO-1,4-THIAZEPIN-5-YL]-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE Chemical Properties,Usage,Production
Uses
KF 38789 inhibits the binding of U937 cells to immobilized P-selectin IgG chimeric protein (P-selectin-Ig) with an IC50 value of 1.97 μM.
Definition
ChEBI: 3-[7-(2,4-dimethoxyphenyl)-1,4-thiazepan-5-ylidene]-6-methylpyran-2,4-dione is a dimethoxybenzene.
Biological Activity
Selective inhibitor of P-selectin-mediated cell adhesion (IC 50 = 1.97 μ M) that displays no effects on L-selectin- and E-selectin-mediated adhesion. Blocks P-selectin-mediated binding in vitro and leukocyte accumulation in vivo .
storage
Desiccate at +4°C
3-[7-(2,4-DIMETHOXYPHENYL)-2,3,6,7-TETRAHYDRO-1,4-THIAZEPIN-5-YL]-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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3-[7-(2,4-DIMETHOXYPHENYL)-2,3,6,7-TETRAHYDRO-1,4-THIAZEPIN-5-YL]-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE Suppliers
257292-29-8, 3-[7-(2,4-DIMETHOXYPHENYL)-2,3,6,7-TETRAHYDRO-1,4-THIAZEPIN-5-YL]-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONERelated Search:
2-ETHYLTHIOMETHYLPHENOL
5-(4-HYDROXYPHENYL)PENTANOIC ACID
3-[7-(2,4-DIMETHOXYPHENYL)-2,3,6,7-TETRAHYDRO-1,4-THIAZEPIN-5-YL]-4-HYDROXY-6-METHYL-2H-PYRAN-2-ONE