ETHYL 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXYLATE

Product Name: ETHYL 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXYLATE
CAS No.: 153597-59-2
Chemical Name: ETHYL 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXYLATE
Synonyms: EOS-61140;ethyl 5H,6H,7H-pyrazolo[3,2-b][1,3]oxazine-2-carboxylate;ETHYL 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXYLATE;5H-Pyrazolo[5,1-b][1,3]oxazine-2-carboxylic acid, 6,7-dihydro-, ethyl ester
CBNumber: CB22449434
Molecular Formula: C9H12N2O3
Formula Weight: 196.2
MOL File: 153597-59-2.mol

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ETHYL 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXYLATE Property

Melting point:: 44-46 °C
Boiling point:: 334.4±22.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 0.59±0.20(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

HazardClass: IRRITANT

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E903045
Product name: ethyl6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxylate
Packaging: 50mg
Price: $155
Updated: 2021/12/16

Matrix Scientific

Product number: 137676
Product name: Ethyl 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxylate
Purity: 95%
Packaging: 1g
Price: $641
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0129095
Product name: ETHYL-6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXYLATE
Purity: 95.00%
Packaging: 1G
Price: $867.12
Updated: 2021/12/16

Matrix Scientific

Product number: 137676
Product name: Ethyl 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxylate
Purity: 95%
Packaging: 2.500g
Price: $1401
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0129095
Product name: ETHYL-6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXYLATE
Purity: 95.00%
Packaging: 5G
Price: $1722.11
Updated: 2021/12/16

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ETHYL 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXYLATE Chemical Properties,Usage,Production

Synthesis

85230-37-1

109-64-8

153597-59-2

Step 1: Preparation of ethyl 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxylate: To a stirred suspension of ethyl 5-keto-4,5-dihydro-1H-pyrazole-3-carboxylate (10.34 g, 0.66 mol) and potassium carbonate (36.62 g) in acetonitrile (500 mL) was slowly added 1,3-dibromopropane (14.7 g). The reaction mixture was heated to reflux for 16 hours. After completion of the reaction, the mixture was cooled to room temperature, filtered and the solid was washed with acetonitrile. The filtrate and washings were combined and concentrated to dryness under reduced pressure to give an oily residue. The residue was dissolved in ethyl acetate and extracted with water. The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product. By further purification, ethyl 6,7-dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-2-carboxylate (8.80 g, 68% yield) was obtained with a melting point of 44-46 °C and a mass spectrum showing the (M + H)+ peak at 197.

References

[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 15, p. 4623 - 4637
[2] Patent: WO2003/93279, 2003, A1. Location in patent: Page/Page column 137
[3] Patent: US2006/276445, 2006, A1. Location in patent: Page/Page column 42
[4] Patent: WO2017/145013, 2017, A1. Location in patent: Page/Page column 54-55
[5] Journal of Heterocyclic Chemistry, 1993, vol. 30, # 4, p. 1097 - 1100

ETHYL 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETHYL 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXYLATE Suppliers

China 30 India 1 United States 4 Global 35

ChemFuture PharmaTech (Jiangsu) Ltd

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153597-59-2, ETHYL 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXYLATERelated Search:

ETHYL 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXYLATE 5-HYDROXY-1-METHYL-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL ESTER (6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZIN-2-YL)METHANOL 5H-Pyrazolo[5,1-b][1,3]oxazine-2-carboxaldehyde, 6,7-dihydro- (9CI) 5-ETHOXY-1H-PYRAZOLE-3-CARBOXYLIC ACID METHYL 5-HYDROXY-PYRAZOLE-3-CARBOXYLATE Ethyl 5-Oxo-4,5-dihydro-1H-pyrazole-3-carboxylate Ethyl 5-hydroxy-1-methyl-1H-pyrazole-3-carboxylate

ETHYL 6,7-DIHYDRO-5H-PYRAZOLO[5,1-B][1,3]OXAZINE-2-CARBOXYLATE

EOS-61140

ethyl 5H,6H,7H-pyrazolo[3,2-b][1,3]oxazine-2-carboxylate

5H-Pyrazolo[5,1-b][1,3]oxazine-2-carboxylic acid, 6,7-dihydro-, ethyl ester

153597-59-2