ChemicalBook > CAS DataBase List > 1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID

1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID

Product Name
1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID
CAS No.
952182-02-4
Chemical Name
1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID
Synonyms
4-b]pyridine-5-carboxylic acid;1H-Pyrazolo[3,4-b]pyridine-5-carboxylicaci;1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID
CBNumber
CB22451002
Molecular Formula
C7H5N3O2
Formula Weight
163.13
MOL File
952182-02-4.mol
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1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID Property

Boiling point:
475.1±25.0 °C(Predicted)
Density 
1.617±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
10.24±0.40(Predicted)
Appearance
Light brown to off-white Solid
InChIKey
DRCBQOFOFJGWGA-UHFFFAOYSA-N
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Safety

Hazard Codes 
Xi
Risk Statements 
36
Safety Statements 
26
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific
Product number
068409
Product name
1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid
Purity
>95%
Packaging
250mg
Price
$140
Updated
2021/12/16
Matrix Scientific
Product number
068409
Product name
1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid
Purity
>95%
Packaging
500mg
Price
$212
Updated
2021/12/16
Matrix Scientific
Product number
068409
Product name
1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid
Purity
>95%
Packaging
1g
Price
$325
Updated
2021/12/16
AK Scientific
Product number
6367AC
Product name
1H-Pyrazolo[3,4-b]pyridine-5-carboxylicacid
Packaging
5g
Price
$728
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0125145
Product name
1H-PYRAZOLO(3,4-B)PYRIDINE-5-CARBOXYLIC ACID
Purity
95.00%
Packaging
250MG
Price
$972.51
Updated
2021/12/16
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1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production

Uses

1H-Pyrazolo[3,4-B]pyridine-5-carboxylic acid is an important pharmaceutical intermediate used in the synthesis of various drug compounds.

Synthesis

1086423-59-7

952182-02-4

Step 5. Ethyl 1-(4-methoxybenzyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylate (4.4 g, 14 mmol) was dissolved in trifluoroacetic acid (TFA, 158 mL) and heated to 80 °C. The reaction mixture was stirred continuously at 80 °C for 4 hours. After completion of the reaction, the mixture was concentrated to dryness under reduced pressure. The residue was carefully poured into ice water and the pH was subsequently adjusted dropwise with 2 M aqueous sodium hydroxide (NaOH) to about 14. The precipitated solid was removed by filtration and the aqueous phase was washed with ethyl acetate. After combining the aqueous phases, the pH was adjusted to neutral (about 7) by slowly adding concentrated hydrochloric acid (HCl). The precipitate precipitated was collected by vacuum filtration and dried under vacuum to afford the target product 1H-pyrazolo[3,4-B]pyridine-5-carboxylic acid as a white solid (1 g, 80% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 14.38-13.62 (br, 1H), 9.07 (d, J = 1.6 Hz, 1H), 8.81 (d, J = 1.6 Hz, 1H), 8.32 (s, 1H). Mass spectrum (ESI+): m/z 164 [M+H]+.

References

[1] Patent: WO2013/127266, 2013, A1. Location in patent: Page/Page column 131; 133
[2] Patent: WO2013/127267, 2013, A1. Location in patent: Page/Page column 83; 84
[3] Patent: WO2013/127268, 2013, A1. Location in patent: Page/Page column 61; 62; 63
[4] Patent: WO2013/130935, 2013, A1. Location in patent: Paragraph 0182
[5] Patent: WO2013/130943, 2013, A1. Location in patent: Paragraph 0190

1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid 952182-02-4
Price
US $1.10-9.90/KG
Min. Order
1KG
Purity
99% min
Supply Ability
100kg
Release date
2025-08-18

952182-02-4, 1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACIDRelated Search:

4-CHLORO-1,3-DIMETHYLPYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID 4-(BUTYLAMINO)-1-ETHYL-6-METHYL 1H-PYRAZOLO[3,4B]PYRIDINE-5-ETHYLCARBOXYLATE HYDROCHLORIDE ETHYL 4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE ETAZOLATE Cartazolate ETHYL 4-(3,5-DICHLOROPHENOXY)-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE ETHYL 4-CHLORO-1-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE ETHYL 4-(4-METHOXYPHENOXY)-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE 1,3-DIMETHYL-4-METHOXYPYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID METHYL 4-METHOXY-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE ETHYL 1,3-DIMETHYL-4-(4-FLUOROPHENOXY)-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE O1-[(4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDIN-5-YL)CARBONYL]-4-METHYLBENZENE-1-CARBOHYDROXIMAMIDE ETHYL 4-[(2-CYANOETHYL)AMINO]-1-METHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE 4-(ISOPROPYLTHIO)-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID ETHYL 1-METHYL-4-(PHENETHYLAMINO)-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE O1-[(4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDIN-5-YL)CARBONYL]-4-(TRIFLUOROMETHYL)BENZENE-1-CARBOHYDROXIMAMIDE ETHYL 1-METHYL-4-([3-(TRIFLUOROMETHYL)BENZYL]AMINO)-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLATE O1-[(4-CHLORO-1,3-DIMETHYL-1H-PYRAZOLO[3,4-B]PYRIDIN-5-YL)CARBONYL]-4-CHLOROBENZENE-1-CARBOHYDROXIMAMIDE

  • 1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID
  • 4-b]pyridine-5-carboxylic acid
  • 1H-Pyrazolo[3,4-b]pyridine-5-carboxylicaci
  • 952182-02-4