ETAZOLATE

Product Name: ETAZOLATE
CAS No.: 51022-77-6
Chemical Name: ETAZOLATE
Synonyms: SQ 64442;SQ 20009;ETAZOLATE;Zinc00001379;Etazolate hydrochlor;ETAZOLATE HYDROCHLORIDE;1-Ethyl-4-[2-(1-Methylethylidene)hydrazinyl]-;1-Ethyl-4-isopropylidenehydrazino-1H-pyrazolo[3,4-b]-1-pyridine-5-carboxylic Acid Ethyl Ester;1-Ethyl-4-(2-isopropylidenehydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester;1-Ethyl-4-isopropylidenehydrazino- 1H-pyrazolo[3,4-β]-1-pyridine-5-carboxylic Acid Ethyl Ester
CBNumber: CB0140566
Molecular Formula: C14H19N5O2
Formula Weight: 289.33
MOL File: 51022-77-6.mol

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ETAZOLATE Property

Melting point:: 193-194°C
Boiling point:: 427.6±55.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
storage temp.: Store at RT
solubility: H₂O: >20 mg/mL Solutions should be freshly prepared.
pka: 9.94±0.70(Predicted)
form: solid
color: white
CAS DataBase Reference: 51022-77-6

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E889250
Product name: Etazolate
Packaging: 25mg
Price: $305
Updated: 2021/12/16

Usbiological

Product number: 448517
Product name: Etazolate Hydrochloride
Packaging: 1mg
Price: $326
Updated: 2021/12/16

Usbiological

Product number: 255268
Product name: Etazolate hydrochloride
Packaging: 10mg
Price: $353
Updated: 2021/12/16

Usbiological

Product number: E8440
Product name: Etazolate
Packaging: 10mg
Price: $403
Updated: 2021/12/16

TRC

Product number: E889250
Product name: Etazolate
Packaging: 50mg
Price: $545
Updated: 2021/12/16

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ETAZOLATE Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

PDE inhibitor

Uses

An inhibitor of phosphodiesterase IV, about 8 times more active for cAMP than cGMP.

Uses

Etazolate Hydrochloride is an acyclic nucleotide phosphodiesterase 4 inhibitor, which also exhibits antidepressant-like activity in acute and chronic mouse and rat model of depression.

Definition

ChEBI: Etazolate is a pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties. It has a role as a neuroprotective agent, an antipsychotic agent, a phosphodiesterase IV inhibitor, an anxiolytic drug, an antidepressant, an alpha-secretase activator and a GABA agent. It is a hydrazone, an ethyl ester and a pyrazolopyridine.

Biological Activity

Phosphodiesterase inhibitor, selective for PDE4 (IC 50 = 2.0 μ M).

ETAZOLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ETAZOLATE Suppliers

Canada 1 China 30 Germany 2 India 1 Japan 1 Switzerland 1 United Kingdom 5 United States 11 Global 52

J & K SCIENTIFIC LTD.

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Shanghai Synchem Pharma Co., ltd

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EMMX Biotechnology LLC

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Wuhan Chemwish Technology Co.， Ltd

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Lanzhou Angeli Biochemical Technology Co., Ltd.

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51022-77-6, ETAZOLATERelated Search:

4-AMINO-3-FORMYLPYRIDINE 4-AMINO-3-FORMYLPYRIDINE HCL 4-HYDRAZINOPYRIDINE HYDROCHLORIDE 4-Amino-3-pyridinecarboxylic acid 1H-PYRAZOLO[3,4-B]PYRIDIN-4-AMINE (4-AMINO-PYRIDIN-3-YL)-METHANOL Methyl 4-aminopyridine-3-carboxylate 3-Methyl-4-aminopyridine Pyridine, 4-hydrazino-3-methyl- (9CI) 1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID 4-AMINOPYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER ETAZOLATE 4-hydrazinylpyridine hydrochloride

ETAZOLATE

ETAZOLATE HYDROCHLORIDE

1-ETHYL-4-[(1-METHYLETHYLIDENE)HYDRAZINO]-1H-PYRAZOLO-[3,4-B]-PYRIDINE-5-CARBOXYLIC ACID, ETHYL ESTER HYDROCHLORIDE

1-ETHYL-4-[(1-METHYLETHYLIDENE)HYDRAZINO]-1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID ETHYL ESTER, HCL

SQ 20009

1-Ethyl-4-[2-(1-methylethylidene)hydrazinyl]-1H-pyrazolo[3,4-β]pyridine-5-carboxylic Acid Ethyl Ester

1-Ethyl-4-isopropylidenehydrazino- 1H-pyrazolo[3,4-β]-1-pyridine-5-carboxylic Acid Ethyl Ester

SQ 64442

1-Ethyl-4-[2-(1-methylethylidene)hydrazinyl]-1H-pyrazolo[3,4-b]pyridine-5-carboxylic Acid Ethyl Ester

1-Ethyl-4-isopropylidenehydrazino-1H-pyrazolo[3,4-b]-1-pyridine-5-carboxylic Acid Ethyl Ester

1-Ethyl-4-(2-isopropylidenehydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

Zinc00001379

1-Ethyl-4-[2-(1-Methylethylidene)hydrazinyl]-

1-Ethyl-4-(N-isopropylidene-hydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

1-ethyl-4-(2-propan-2-ylidenehydrazinyl)-5-pyrazolo[3,4-b]pyridinecarboxylic acid ethyl ester hydrochloride

1H-Pyrazolo[3,4-b]pyridine-5-carboxylic acid, 1-ethyl-4-[2-(1-methylethylidene)hydrazinyl]-, ethyl ester

Etazolate hydrochlor

51022-77-6

C14H20ClN5O2

C14H20N5O2Cl

G Proteins and Cyclic Nucleotides

Cyclic Nucleotide Metabolism

Phosphodiesterase Inhibitors

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