4-Amino-3-pyridinecarboxylic acid
- Product Name
- 4-Amino-3-pyridinecarboxylic acid
- CAS No.
- 7418-65-7
- Chemical Name
- 4-Amino-3-pyridinecarboxylic acid
- Synonyms
- 4-AMINONICOTINIC ACID;4-AMINOPYRIDINE-3-CARBOXYLIC ACID;H-4ANIC-OH;AURORA KA-2553;AKOS BBS-00001375;IFLAB-BB F1957-0006;RARECHEM AL BE 1386;4-Aminonicotinc acid;4-AminonicotinicAcid98%;4-Aminonicotinic acid 99%
- CBNumber
- CB7184989
- Molecular Formula
- C6H6N2O2
- Formula Weight
- 138.12
- MOL File
- 7418-65-7.mol
4-Amino-3-pyridinecarboxylic acid Property
- Melting point:
- 307-312 °C
- Boiling point:
- 253.51°C (rough estimate)
- Density
- 1.3471 (rough estimate)
- refractive index
- 1.5100 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- Soluble in aqueous acid and base.
- pka
- 2.94±0.10(Predicted)
- form
- Powder
- color
- Cream to yellow
- InChI
- InChI=1S/C6H6N2O2/c7-5-1-2-8-3-4(5)6(9)10/h1-3H,(H2,7,8)(H,9,10)
- InChIKey
- IASBMUIXBJNMDW-UHFFFAOYSA-N
- SMILES
- C1=NC=CC(N)=C1C(O)=O
- CAS DataBase Reference
- 7418-65-7(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 11585
- Product name
- 4-Amino-nicotinic acid
- Purity
- ≥97.0% (HPLC)
- Packaging
- 5G
- Price
- $76.1
- Updated
- 2025/07/31
- Product number
- 20733
- Product name
- 4-amino Nicotinic Acid
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 20733
- Product name
- 4-amino Nicotinic Acid
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $93
- Updated
- 2024/03/01
- Product number
- 20733
- Product name
- 4-amino Nicotinic Acid
- Purity
- ≥98%
- Packaging
- 10g
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 20733
- Product name
- 4-amino Nicotinic Acid
- Purity
- ≥98%
- Packaging
- 25g
- Price
- $305
- Updated
- 2024/03/01
4-Amino-3-pyridinecarboxylic acid Chemical Properties,Usage,Production
Description
4-amino Nicotinic acid is a synthetic intermediate that has been used in various syntheses.
Chemical Properties
Light yellow Cryst
Uses
4-Aminonicotinic acid has been used in the preparation of 2-methyl-pyrido-oxazine. It is also used as pharmaceutical intermediate.
Definition
ChEBI: 4-aminonicotinic acid is an aminonicotinic acid in which the amino group is situated at position 4 of the pyridine ring. It has a role as a metabolite. It is an aromatic amine, an aminopyridine and an aminonicotinic acid. It is functionally related to a 4-aminopyridine and a nicotinic acid.
General Description
4-Amino-nicotinic acid is a white to light yellow and faint beige to light beige and faint brown to light brown powder or crystals.
Synthesis
16135-36-7
7418-65-7
The general procedure for the synthesis of 4-aminopyridine-3-carboxylic acid from 4-aminonicotinic acid methyl ester was as follows: to an aqueous ethanol solution of 4-aminopyridine-3-carboxylic acid methyl ester (2 g, 13.15 mmol) in stirring (120 mL, V/V=1:1) was added LiOH-H2O (1.21 g, 28.80 mmol) at room temperature, and the reaction mixture was subsequently heated to 80°C for 2 h (the progress of the reaction was monitored by TLC to confirm complete consumption of the feedstock). After completion of the reaction, the volatiles were removed under reduced pressure to give the crude product. The crude product was dissolved in water (30 mL) and washed with ethyl acetate (2 x 25 mL) to remove non-polar impurities. The aqueous layer was acidified to pH=1 with 1N HCl solution and subsequently extracted with ethyl acetate (2 x 10 mL). The organic extracts were combined and concentrated under reduced pressure to give a crude residue. The crude product was purified by crystallization from methanol (20 mL) to give finally 4-aminopyridine-3-carboxylic acid (1 g, 55% yield) as an off-white solid.LCMS (ESI+): m/z: 139.31 [M+H]+.
References
[1] Patent: WO2018/125961, 2018, A1. Location in patent: Page/Page column 98; 99; 100
4-Amino-3-pyridinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Amino-3-pyridinecarboxylic acid manufacturers
- Product
- 4-Amino-3-pyridinecarboxylic acid 7418-65-7
- Price
- US $8.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10tons
- Release date
- 2018-12-25