Methyl 2-aminopyridine-4-carboxylate

Product Name: Methyl 2-aminopyridine-4-carboxylate
CAS No.: 6937-03-7
Chemical Name: Methyl 2-aminopyridine-4-carboxylate
Synonyms: METHYL 2-AMINOISONICOTINATE;2-Aminopyridine-4-carboxylic acid methyl ester;NSC 40138;Methyl 2-aMinopy;CHEMBRDG-BB 4015127;2-aminopyridine-4-carboxyL;2- aMinoMethyl isonicotinate;Methyl2-Aminoisonicotinate>Methyl 2-aminoisonicotinate 98%;Methyl 2-aminoisonicotinate, 98%
CBNumber: CB1212183
Molecular Formula: C7H8N2O2
Formula Weight: 152.15
MOL File: 6937-03-7.mol

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Methyl 2-aminopyridine-4-carboxylate Property

Melting point:: 144-148 °C
Boiling point:: 296.1±20.0 °C(Predicted)
Density: 1.238±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Chloroform
pka: 4.89±0.11(Predicted)
form: Crystalline Powder
color: White to brown
Water Solubility: Insoluble in water.
BRN: 128642
InChI: InChI=1S/C7H8N2O2/c1-11-7(10)5-2-3-9-6(8)4-5/h2-4H,1H3,(H2,8,9)
InChIKey: SVWWNEYBEFASMP-UHFFFAOYSA-N
SMILES: C1(N)=NC=CC(C(OC)=O)=C1
CAS DataBase Reference: 6937-03-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38-41-20/22
Safety Statements: 26-36-26/36-39-36/37/39-22
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 704482
Product name: Methyl 2-aminopyridine-4-carboxylate
Purity: 97%
Packaging: 1g
Price: $76.3
Updated: 2023/06/20

Sigma-Aldrich

Product number: 704482
Product name: Methyl 2-aminopyridine-4-carboxylate
Purity: 97%
Packaging: 5G
Price: $137
Updated: 2023/06/20

TCI Chemical

Product number: M2172
Product name: Methyl 2-Aminoisonicotinate
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $30
Updated: 2025/07/31

TCI Chemical

Product number: M2172
Product name: Methyl 2-Aminoisonicotinate
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $88
Updated: 2025/07/31

TRC

Product number: M286840
Product name: Methyl 2-Aminoisonicotinate
Packaging: 2.5g
Price: $70
Updated: 2021/12/16

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Methyl 2-aminopyridine-4-carboxylate Chemical Properties,Usage,Production

Chemical Properties

Tan Solid

Uses

Methyl 2-aminopyridine-4-carboxylate is an inhibitor of nitrogen monoxide synthetase.

Uses

A nitrogen monoxide synthetase inhibitor.

Synthesis Reference(s)

The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y

Synthesis

67-56-1

13362-28-2

6937-03-7

The general procedure for the synthesis of methyl 2-aminoisonicotinate from methanol and 2-aminoisonicotinic acid was as follows: 2-aminoisonicotinic acid (207 g, 1.5 mol) was dissolved in methanol (1.8 L) to prepare a solution. The solution was slowly added dropwise to thionyl chloride (238 g, 2 mol) at 50 °C. After the dropwise addition was completed, the reaction temperature was maintained at 50 °C and the reaction mixture continued to be stirred for 5 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. To the residue, saturated aqueous sodium carbonate solution was added and the pH was adjusted to 9-10 to make the reaction mixture basic. Subsequently, the mixed solution was extracted with dichloromethane (300 ml each time for 3 times). The organic layers were combined and dried with anhydrous sodium sulfate. Finally, the solvent was removed by concentration to give methyl 2-aminoisonicotinate (189 g, 83% yield) as a yellow solid. The structure of the product was confirmed by 1H-NMR (d6-DMSO, 300 MHz): δ 3.96 (s, 3H); 7.14 (d, 1H); 7.49 (br, 1H); 8.07 (d, 1H); 8.18 (br, 2H, NH).

References

[1] European Journal of Medicinal Chemistry, 2013, vol. 61, p. 26 - 40
[2] Journal of the American Chemical Society, 2018, vol. 140, # 9, p. 3322 - 3330
[3] Chemistry - A European Journal, 2012, vol. 18, # 27, p. 8498 - 8507
[4] Patent: EP3018125, 2016, A1. Location in patent: Paragraph 0515-0518
[5] Russian Journal of Organic Chemistry, 2015, vol. 51, # 5, p. 744 - 745

Methyl 2-aminopyridine-4-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

TERT-BUTYL 4-(HYDROXYMETHYL)PYRIDIN-2-YLCARBAMATE TERT-BUTYL 4-(AMINOMETHYL)PYRIDIN-2-YLCARBAMATE (2-TERT-BUTOXYFORMAMIDO-PYRIDIN-4-YL)METHYL METHANESULFONATE TERT-BUTYL 4-(METHOXYCARBONYL)PYRIDIN-2-YLCARBAMATE

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Methyl 2-aminopyridine-4-carboxylate Suppliers

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View Lastest Price from Methyl 2-aminopyridine-4-carboxylate manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Methyl 2-aminopyridine-4-carboxylate 6937-03-7
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2025-03-10

Shaanxi Dideu New Materials Co. Ltd

Product: Methyl 2-aminopyridine-4-carboxylate 6937-03-7
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10000KGS
Release date: 2025-03-01

Hebei Zhanyao Biotechnology Co. Ltd

Product: Methyl 2-aminopyridine-4-carboxylate 6937-03-7
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2021-10-13

6937-03-7, Methyl 2-aminopyridine-4-carboxylateRelated Search:

Methyl anthranilate 2,5-PYRIDINEDICARBOXYLIC ACID 3-Aminopyridine 4-Dimethylaminopyridine Lithium diisopropylamide METSULFURON METHYL Acetaminophen Kresoxim-methyl Sulfamic acid Basic Violet 1 Methyl isonicotinate Tribenuron methyl Methylparaben 2-Aminoisonicotinic acid RESMETHRIN Methyl acrylate Methyl carbamate Methanol

METHYL 2-AMINOISONICOTINATE

METHYL 2-AMINOPYRIDINE-4-CARBOXYLATE

CHEMBRDG-BB 4015127

2-Aminopyridinecarboxylic acid methyl ester~Methyl 2-aminoisonicotinate

2-Aminopyridine-4-carboxylic acid methyl ester

2-aminopyridinecarboxylic acid methyl ester

2-amino-3-methyl-4-pyridinecarboxylate

Methyl 2-aminoisonicotinate 98%

2-Amniopyridine-4-carboxylic acid methyl ester

methyl 2-aminoisonicotinate(SALTDATA: FREE)

Methyl 2-aminopyridine-4-carboxylate, 4-(Methoxycarbonyl)pyridin-2-amine

methyl 2-aminoisonicotinate, (2-Amino-4-pyridinecarboxylic acid methylester)

Methyl 2-Amino-4-pyridinecarboxylate

NSC 40138

2-Aminoisonicotinic Acid Methyl Ester Methyl 2-Aminopyridine-4-carboxylate 2-Aminopyridine-4-carboxylic Acid Methyl Ester

Methyl 2-aMinoisonicotinate-CAS6937-03-7

Methyl 2-aMinopy

2- aMinoMethyl isonicotinate

Methyl 2-aMinopyridine-4-carboxylate, >95%

4-Pyridinecarboxylic acid, 2-amino-, methyl ester

Methyle2-aminopyridine-4-carboxylate

Methyl2-Aminoisonicotinate&gt

2-aminopyridine-4-carboxyL

Methyl 2-aminopyridine-4-carboxylate ISO 9001：2015 REACH

4-Pyridinecarboxylic acid, 2-amino-, methyl ester (9CI, ACI)

2-amino-4-Pyridinecarboxylic acid methyl ester (9CI ACI)

Methyl 2-aminoisonicotinate, 98%

Methyl 2-aminoisopyridin-3-carboxylate

6937-03-7

1839794

6837-03-7

Amines

Heterocycles

Inhibitors

Esters

Pyridines

Pyridine

API intermediates

Heterocycle-Pyridine series