ChemicalBook > CAS DataBase List > ETAZOLATE
ETAZOLATE
- Product Name
- ETAZOLATE
- CAS No.
- 51022-77-6
- Chemical Name
- ETAZOLATE
- Synonyms
- SQ 64442;SQ 20009;ETAZOLATE;Zinc00001379;Etazolate hydrochlor;ETAZOLATE HYDROCHLORIDE;1-Ethyl-4-[2-(1-Methylethylidene)hydrazinyl]-;1-Ethyl-4-isopropylidenehydrazino-1H-pyrazolo[3,4-b]-1-pyridine-5-carboxylic Acid Ethyl Ester;1-Ethyl-4-(2-isopropylidenehydrazino)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester;1-Ethyl-4-isopropylidenehydrazino- 1H-pyrazolo[3,4-β]-1-pyridine-5-carboxylic Acid Ethyl Ester
- CBNumber
- CB0140566
- Molecular Formula
- C14H19N5O2
- Formula Weight
- 289.33
- MOL File
- 51022-77-6.mol
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ETAZOLATE Property
- Melting point:
- 193-194°C
- Boiling point:
- 427.6±55.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- H2O: >20 mg/mL Solutions should be freshly prepared.
- pka
- 9.94±0.70(Predicted)
- form
- solid
- color
- white
- CAS DataBase Reference
- 51022-77-6
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N-Bromosuccinimide Price
TRC
- Product number
- E889250
- Product name
- Etazolate
- Packaging
- 25mg
- Price
- $305
- Updated
- 2021/12/16
Usbiological
- Product number
- 448517
- Product name
- Etazolate Hydrochloride
- Packaging
- 1mg
- Price
- $326
- Updated
- 2021/12/16
Usbiological
- Product number
- 255268
- Product name
- Etazolate hydrochloride
- Packaging
- 10mg
- Price
- $353
- Updated
- 2021/12/16
Usbiological
- Product number
- E8440
- Product name
- Etazolate
- Packaging
- 10mg
- Price
- $403
- Updated
- 2021/12/16
TRC
- Product number
- E889250
- Product name
- Etazolate
- Packaging
- 50mg
- Price
- $545
- Updated
- 2021/12/16
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ETAZOLATE Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
PDE inhibitor
Uses
An inhibitor of phosphodiesterase IV, about 8 times more active for cAMP than cGMP.
Uses
Etazolate Hydrochloride is an acyclic nucleotide phosphodiesterase 4 inhibitor, which also exhibits antidepressant-like activity in acute and chronic mouse and rat model of depression.
Definition
ChEBI: Etazolate is a pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine which is substituted at positions 1, 4, and 5 by ethyl, 2-isopropylidenehydrazino, and ethoxycarbonyl groups, respectively. A phosphodiesterase IV inhibitor with antidepressant and anxiolytic properties. It has a role as a neuroprotective agent, an antipsychotic agent, a phosphodiesterase IV inhibitor, an anxiolytic drug, an antidepressant, an alpha-secretase activator and a GABA agent. It is a hydrazone, an ethyl ester and a pyrazolopyridine.
Biological Activity
Phosphodiesterase inhibitor, selective for PDE4 (IC 50 = 2.0 μ M).
ETAZOLATE Preparation Products And Raw materials
Raw materials
Preparation Products
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ETAZOLATE Suppliers
51022-77-6, ETAZOLATERelated Search:
4-AMINO-3-FORMYLPYRIDINE
4-AMINO-3-FORMYLPYRIDINE HCL
4-HYDRAZINOPYRIDINE HYDROCHLORIDE
4-Amino-3-pyridinecarboxylic acid
1H-PYRAZOLO[3,4-B]PYRIDIN-4-AMINE
(4-AMINO-PYRIDIN-3-YL)-METHANOL
Methyl 4-aminopyridine-3-carboxylate
3-Methyl-4-aminopyridine
Pyridine, 4-hydrazino-3-methyl- (9CI)
1H-PYRAZOLO[3,4-B]PYRIDINE-5-CARBOXYLIC ACID
4-AMINOPYRIDINE-3-CARBOXYLIC ACID ETHYL ESTER
ETAZOLATE
4-hydrazinylpyridine hydrochloride