PYRAZOLO[1,5-A]PYRIDIN-2-OL

Product Name: PYRAZOLO[1,5-A]PYRIDIN-2-OL
CAS No.: 59942-87-9
Chemical Name: PYRAZOLO[1,5-A]PYRIDIN-2-OL
Synonyms: PYRAZOLO[1,5-A]PYRIDIN-2-OL;Pyrazolo[1,5-a]pyridin-2(1H);1H-pyrazolo[1,5-a]pyridin-2-one;2-hydroxypyrazolo[1,5-a]pyridine;Pyrazolo[1,5-a]pyridin-2(1H)-one
CBNumber: CB22451936
Molecular Formula: C7H6N2O
Formula Weight: 134.14
MOL File: 59942-87-9.mol

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PYRAZOLO[1,5-A]PYRIDIN-2-OL Property

Melting point:: 127-128 °C(Solv: hexane (110-54-3); benzene (71-43-2))
Density: 1.36
storage temp.: Sealed in dry,Room Temperature
pka: 10.08±0.20(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: P993465
Product name: Pyrazolo[1,5-a]pyridin-2(1H)-one
Packaging: 10mg
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0158269
Product name: PYRAZOLO(1,5-A)PYRIDIN-2-OL
Purity: 96.00%
Packaging: 250MG
Price: $831.6
Updated: 2021/12/16

Matrix Scientific

Product number: 132311
Product name: Pyrazolo[1,5-a]pyridin-2-ol
Purity: 97%
Packaging: 1g
Price: $1018
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0158269
Product name: PYRAZOLO(1,5-A)PYRIDIN-2-OL
Purity: 96.00%
Packaging: 1G
Price: $1127.28
Updated: 2021/12/16

Matrix Scientific

Product number: 132311
Product name: Pyrazolo[1,5-a]pyridin-2-ol
Purity: 97%
Packaging: 5g
Price: $1797
Updated: 2021/12/16

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PYRAZOLO[1,5-A]PYRIDIN-2-OL Chemical Properties,Usage,Production

Synthesis

2739-98-2

59942-87-9

1b) Synthesis of 2-hydroxypyrazolo[1,5-a]pyridine (C4f): the method was carried out with reference to the literature (Ochi, M.; Miyasaka, T.; Kanada, K.; Arakawa, K. Bull. Chem. Soc. Japan, 1976, 49, 1980-1984). At 0 °C, 4.14 g (36.6 mmol) of hydroxylamine-O-sulfonic acid was dissolved in 13.8 mL of water, neutralized with 2.6 N KOH solution, and added slowly and dropwise to 26.2 mL (0.172 mol) of ethyl 2-pyridylacetate. The reaction mixture was stirred at room temperature for 30 hours. Subsequently, the mixture was extracted with dichloromethane and the aqueous layer was adjusted to pH 9 with 10% Na2CO3 solution and extracted again with dichloromethane. Next, the aqueous layer was adjusted to pH 5 with acetic acid and extracted with dichloromethane. The organic layers were combined, dried with MgSO4 and concentrated. The crude product was purified by fast chromatography (hexane/EtOAc = 90:10) to give 607 mg (39%) of white solid product. Melting point: 127-128 °C. MS (APCI): m/z 135 (M + 1)+. 1H NMR (DMSO-d6, 360 MHz) δ (ppm): 5.72 (d, J = 0.8 Hz, 1H, H-3); 6.63 (ddd, J = 6.8 Hz, 6.8 Hz, 1.4 Hz, 1H, H-6); 7.08 (ddd , J = 8.9 Hz, 6.8 Hz, 1.1 Hz, 1H, H-5); 7.35 (ddd, J = 8.9 Hz, 1.4 Hz, 0.8 Hz, 1H, H-4); 8.32 (dd, J = 6.8 Hz, 1.1 Hz, 1H, H-7); 10.40 (s, 1H, OH).

References

[1] Patent: EP1972628, 2008, A1. Location in patent: Page/Page column 31
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 11, p. 4861 - 4875

PYRAZOLO[1,5-A]PYRIDIN-2-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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PYRAZOLO[1,5-A]PYRIDIN-2-OL Suppliers

China 68 India 2 United States 10 Global 80

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View Lastest Price from PYRAZOLO[1,5-A]PYRIDIN-2-OL manufacturers

Career Henan Chemical Co

Product: PYRAZOLO[1,5-A]PYRIDIN-2-OL 59942-87-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: G/KG/T
Release date: 2019-12-24

59942-87-9, PYRAZOLO[1,5-A]PYRIDIN-2-OLRelated Search:

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PYRAZOLO[1,5-A]PYRIDIN-2-OL

Pyrazolo[1,5-a]pyridin-2(1H)-one

2-hydroxypyrazolo[1,5-a]pyridine

Pyrazolo[1,5-a]pyridin-2(1H)

1H-pyrazolo[1,5-a]pyridin-2-one

59942-87-9