5-Hydroxypyrazolo[1,5-a]pyrimidine
- Product Name
- 5-Hydroxypyrazolo[1,5-a]pyrimidine
- CAS No.
- 29274-22-4
- Chemical Name
- 5-Hydroxypyrazolo[1,5-a]pyrimidine
- Synonyms
- 4H,5H-pyrazolo;pyrazoloapyrimidinone;Larotrectinib PPO Impurity;Pyrazolo[1,5-a]pyrimidin-5-ol;Pyrazolo[1,5-a]pyrimidine-5-ol;1H-pyrazolo[1,5-a]pyrimidin-5-one;5-Hydroxypyrazolo[1,5-a]pyrimidine;4H,5H-pyrazolo[1,5-a]pyriMidin-5-one;Pyrazolo [1,5-A] pyrimidine-5 (4H) - one;Pyrazoland [1,5-a] pyrimidine-5 (4H) -ONE
- CBNumber
- CB42471224
- Molecular Formula
- C6H5N3O
- Formula Weight
- 135.12
- MOL File
- 29274-22-4.mol
5-Hydroxypyrazolo[1,5-a]pyrimidine Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C6H5N3O/c10-6-2-4-9-5(8-6)1-3-7-9/h1-4H,(H,8,10)
- InChIKey
- LSLIYLLMLAQRIS-UHFFFAOYSA-N
- SMILES
- C12=CC=NN1C=CC(=O)N2
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P322Specific measures (see …on this label).
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P993478
- Product name
- Pyrazolo[1,5-A]pyrimidin-5-ol
- Packaging
- 500mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- 054358
- Product name
- Pyrazolo[1,5-a]pyrimidin-5(4H)-one
- Purity
- >95%
- Packaging
- 500mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 4H48-1-6R
- Product name
- Pyrazolo[1,5-a]pyrimidin-5(4H)-one
- Purity
- 97%
- Packaging
- 1g
- Price
- $256
- Updated
- 2021/12/16
- Product number
- 054358
- Product name
- Pyrazolo[1,5-a]pyrimidin-5(4H)-one
- Purity
- >95%
- Packaging
- 1g
- Price
- $360
- Updated
- 2021/12/16
- Product number
- 054358
- Product name
- Pyrazolo[1,5-a]pyrimidin-5(4H)-one
- Purity
- >95%
- Packaging
- 5g
- Price
- $980
- Updated
- 2021/12/16
5-Hydroxypyrazolo[1,5-a]pyrimidine Chemical Properties,Usage,Production
Synthesis
1001-26-9
1225387-53-0
29274-22-4
The general procedure for the synthesis of pyrazolo[1,5-a]pyrimidin-5-ol from ethyl 3-ethoxyacrylate and 3H-pyrazol-3-amine was as follows: 5-aminopyrazole (5 g, 60 mmol), ethyl 3-ethoxyacrylate (13 g, 90 mmol) and cesium carbonate (29 g, 90 mmol) were mixed in 100 ml of N,N-dimethylformamide. The reaction mixture was stirred at 110 °C overnight. After the reaction was completed, it was cooled to room temperature, diluted with 200 ml of water and then extracted with ether (40 mL x 3). The aqueous phase was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent ratio of dichloromethane: methanol = 10:1) to afford 4H-pyrazolo[1,5-a]pyrimidin-5-one (8 g) in 99% yield.
References
[1] Patent: CN104250252, 2017, B. Location in patent: Paragraph 0095; 0097; 0098
[2] Journal of Organic Chemistry, 2007, vol. 72, # 3, p. 1043 - 1046
5-Hydroxypyrazolo[1,5-a]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
5-Hydroxypyrazolo[1,5-a]pyrimidine Suppliers
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44802
- Advantage
- 61
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 021-50718719 13918719472
- Fax
- 021-50718719
- Country
- China
- ProdList
- 979
- Advantage
- 58
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 21-33585366 13311639313
- Fax
- +86-21-34979012
- sales@shyrchem.com
- Country
- China
- ProdList
- 806
- Advantage
- 55
- Tel
- +86-021-50720296
- Fax
- +86-021-50720297
- service@synkinase.com
- Country
- China
- ProdList
- 266
- Advantage
- 58
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
- Tel
- 0551-66399836 18955197623
- sales@enlipharma.com
- Country
- China
- ProdList
- 1876
- Advantage
- 55
- Tel
- 0531-82375892 15562613975
- 34116953599@qq.com
- Country
- China
- ProdList
- 293
- Advantage
- 58
View Lastest Price from 5-Hydroxypyrazolo[1,5-a]pyrimidine manufacturers
- Product
- 1H-pyrazolo[1,5-a]pyrimidin-5-one 29274-22-4
- Price
- US $0.00/g
- Min. Order
- 20g
- Purity
- 0.99
- Supply Ability
- 1000kg
- Release date
- 2023-09-22
- Product
- 5-Hydroxypyrazolo[1,5-a]pyrimidine 29274-22-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100
- Release date
- 2021-12-18
- Product
- 5-Hydroxypyrazolo[1,5-a]pyrimidine 29274-22-4
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons
- Release date
- 2022-02-16