ChemicalBook > CAS DataBase List > 5-Hydroxypyrazolo[1,5-a]pyrimidine

5-Hydroxypyrazolo[1,5-a]pyrimidine

Product Name
5-Hydroxypyrazolo[1,5-a]pyrimidine
CAS No.
29274-22-4
Chemical Name
5-Hydroxypyrazolo[1,5-a]pyrimidine
Synonyms
4H,5H-pyrazolo;pyrazoloapyrimidinone;Larotrectinib PPO Impurity;Pyrazolo[1,5-a]pyrimidin-5-ol;Pyrazolo[1,5-a]pyrimidine-5-ol;1H-pyrazolo[1,5-a]pyrimidin-5-one;5-Hydroxypyrazolo[1,5-a]pyrimidine;4H,5H-pyrazolo[1,5-a]pyriMidin-5-one;Pyrazolo [1,5-A] pyrimidine-5 (4H) - one;Pyrazoland [1,5-a] pyrimidine-5 (4H) -ONE
CBNumber
CB42471224
Molecular Formula
C6H5N3O
Formula Weight
135.12
MOL File
29274-22-4.mol
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5-Hydroxypyrazolo[1,5-a]pyrimidine Property

storage temp. 
Sealed in dry,Room Temperature
Appearance
White to off-white Solid
InChI
InChI=1S/C6H5N3O/c10-6-2-4-9-5(8-6)1-3-7-9/h1-4H,(H,8,10)
InChIKey
LSLIYLLMLAQRIS-UHFFFAOYSA-N
SMILES
C12=CC=NN1C=CC(=O)N2
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Safety

HazardClass 
IRRITANT
HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P322Specific measures (see …on this label).

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
P993478
Product name
Pyrazolo[1,5-A]pyrimidin-5-ol
Packaging
500mg
Price
$310
Updated
2021/12/16
Matrix Scientific
Product number
054358
Product name
Pyrazolo[1,5-a]pyrimidin-5(4H)-one
Purity
>95%
Packaging
500mg
Price
$180
Updated
2021/12/16
SynQuest Laboratories
Product number
4H48-1-6R
Product name
Pyrazolo[1,5-a]pyrimidin-5(4H)-one
Purity
97%
Packaging
1g
Price
$256
Updated
2021/12/16
Matrix Scientific
Product number
054358
Product name
Pyrazolo[1,5-a]pyrimidin-5(4H)-one
Purity
>95%
Packaging
1g
Price
$360
Updated
2021/12/16
Matrix Scientific
Product number
054358
Product name
Pyrazolo[1,5-a]pyrimidin-5(4H)-one
Purity
>95%
Packaging
5g
Price
$980
Updated
2021/12/16
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5-Hydroxypyrazolo[1,5-a]pyrimidine Chemical Properties,Usage,Production

Synthesis

1001-26-9

1225387-53-0

29274-22-4

The general procedure for the synthesis of pyrazolo[1,5-a]pyrimidin-5-ol from ethyl 3-ethoxyacrylate and 3H-pyrazol-3-amine was as follows: 5-aminopyrazole (5 g, 60 mmol), ethyl 3-ethoxyacrylate (13 g, 90 mmol) and cesium carbonate (29 g, 90 mmol) were mixed in 100 ml of N,N-dimethylformamide. The reaction mixture was stirred at 110 °C overnight. After the reaction was completed, it was cooled to room temperature, diluted with 200 ml of water and then extracted with ether (40 mL x 3). The aqueous phase was concentrated under reduced pressure and the residue was purified by silica gel column chromatography (eluent ratio of dichloromethane: methanol = 10:1) to afford 4H-pyrazolo[1,5-a]pyrimidin-5-one (8 g) in 99% yield.

References

[1] Patent: CN104250252, 2017, B. Location in patent: Paragraph 0095; 0097; 0098
[2] Journal of Organic Chemistry, 2007, vol. 72, # 3, p. 1043 - 1046

5-Hydroxypyrazolo[1,5-a]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Hydroxypyrazolo[1,5-a]pyrimidine Suppliers

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View Lastest Price from 5-Hydroxypyrazolo[1,5-a]pyrimidine manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
1H-pyrazolo[1,5-a]pyrimidin-5-one 29274-22-4
Price
US $0.00/g
Min. Order
20g
Purity
0.99
Supply Ability
1000kg
Release date
2023-09-22
Jinan Ande Pharmaceutical Co.,Ltd.
Product
5-Hydroxypyrazolo[1,5-a]pyrimidine 29274-22-4
Price
US $0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100
Release date
2021-12-18
Dideu Industries Group Limited
Product
5-Hydroxypyrazolo[1,5-a]pyrimidine 29274-22-4
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons
Release date
2022-02-16

29274-22-4, 5-Hydroxypyrazolo[1,5-a]pyrimidineRelated Search:

PYRAZOLO[1,5-A]PYRIDINE-2-CARBOXYLIC ACID AMIDE Pyrazolo[1,5-a]pyridine C-PYRAZOLO[1,5-A]PYRIDIN-7-YL-METHYLAMINE PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBONITRILE PYRAZOLO[1,5-A]PYRIDIN-2-OL PYRAZOLO[1,5-A]PYRIMIDINE-5-CARBOXYLICACID 4H-PYRAZOLO[1,5-A]PYRIMIDIN-7-ONE Pyrazolo[1,5-a]pyrimidin-6-ol Pyrazolo[1,5-a]pyriMidin-7-ol PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBALDEHYDE methyl pyrazolo[1,5-a]pyrimidine-3-carboxylate Pyrazolo[1,5-a]pyrimidin-7-amine PYRAZOLO[1,5-A]PYRIMIDINE PYRAZOLO[1,5-A]PYRIMIDINE-3-CARBOXYLIC ACID ETHYL ESTER Pyrazolo[1,5-a]pyridine-3-carboxylic acid 2-Methylpyrazolo[1,5-a]pyrimidin-7-ol PYRAZOLO[1,5-A]PYRIMIDINE-6-CARBOXYLIC ACID Pyrazolo[1,5-a]quinoxalin-4(5H)-one (6CI)

  • 5-Hydroxypyrazolo[1,5-a]pyrimidine
  • Pyrazolo[1,5-a]pyrimidin-5-ol
  • 4H,5H-pyrazolo[1,5-a]pyriMidin-5-one
  • 1H-pyrazolo[1,5-a]pyrimidin-5-one
  • pyrazolo[1,5-a]pyrimidin-5(4H)-one(WXC06578)
  • pyrazoloapyrimidinone
  • Larotrectinib Impurity 6（Larotrectinib PPO Impurity）
  • 4H,5H-pyrazolo
  • Larotrectinib PPO Impurity
  • Pyrazoland [1,5-a] pyrimidine-5 (4H) -ONE
  • 5-Hydroxypyrazolo[1,5-a]pyrimidine ISO 9001：2015 REACH
  • Pyrazolo[1,5-a]pyrimidine-5-ol
  • Pyrazolo[1,5-a]pyrimidin-5(4H)-one (8CI, 9CI, ACI)
  • Pyrazolo [1,5-A] pyrimidine-5 (4H) - one
  • 29274-22-4