1,6-DIBROMO-3-ISOQUINOLINAMINE
- Product Name
- 1,6-DIBROMO-3-ISOQUINOLINAMINE
- CAS No.
- 925672-85-1
- Chemical Name
- 1,6-DIBROMO-3-ISOQUINOLINAMINE
- Synonyms
- 1,6-DIBROMO-3-ISOQUINOLINAMINE;3-Isoquinolinamine, 1,6-dibromo-
- CBNumber
- CB22453763
- Molecular Formula
- C9H6Br2N2
- Formula Weight
- 301.97
- MOL File
- 925672-85-1.mol
1,6-DIBROMO-3-ISOQUINOLINAMINE Property
- Boiling point:
- 439.9±40.0 °C(Predicted)
- Density
- 1.994±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 1.16±0.50(Predicted)
N-Bromosuccinimide Price
- Product number
- D424685
- Product name
- 1,6-Dibromoisoquinolin-3-amine
- Packaging
- 50mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FD144097
- Product name
- 1,6-Dibromoisoquinolin-3-amine
- Packaging
- 100mg
- Price
- $79
- Updated
- 2021/12/16
- Product number
- Z5352
- Product name
- 1,6-Dibromoisoquinolin-3-amine
- Packaging
- 100mg
- Price
- $138
- Updated
- 2021/12/16
- Product number
- FD144097
- Product name
- 1,6-Dibromoisoquinolin-3-amine
- Packaging
- 250mg
- Price
- $157.5
- Updated
- 2021/12/16
- Product number
- FD144097
- Product name
- 1,6-Dibromoisoquinolin-3-amine
- Packaging
- 500mg
- Price
- $275
- Updated
- 2021/12/16
1,6-DIBROMO-3-ISOQUINOLINAMINE Chemical Properties,Usage,Production
Synthesis
925672-88-4
925672-85-1
The general procedure for the synthesis of 1,6-dibromoisoquinolin-3-amine from 5-bromo-2-cyanophenylacetonitrile was as follows: 4-bromo-2-(cyanomethyl)benzonitrile (75 g, 339 mmol) was dissolved in 2,2-dichloroacetic acid (150 mL, 339 mmol). The reaction mixture was cooled to 0°C in an ice water bath. HBr gas (27.5 g, 339 mmol) was passed into the cooled solution until a yellow precipitate was observed to precipitate and form a yellow slurry. The passage of HBr gas was continued for 5 min. Subsequently, the reaction mixture was slowly warmed up to room temperature over a period of 1 hour. The slurry was again cooled to 0 °C in an ice water bath and ether (200 mL) was added. The mixture was stirred at 5 °C for 20 min. The yellow solid product was collected by filtration to give 1,6-dibromoisoquinolin-3-amine (42 g, 41% yield). lcms (API-ES) m/z: 303 (M + H+).
References
[1] Tetrahedron Letters, 2007, vol. 48, # 3, p. 487 - 489
[2] Patent: WO2009/11871, 2009, A2. Location in patent: Page/Page column 188; 189
[3] Patent: WO2009/11880, 2009, A2. Location in patent: Page/Page column 159-160
[4] Patent: WO2010/83246, 2010, A1. Location in patent: Page/Page column 54; 55
1,6-DIBROMO-3-ISOQUINOLINAMINE Preparation Products And Raw materials
Raw materials
Preparation Products
1,6-DIBROMO-3-ISOQUINOLINAMINE Suppliers
- Tel
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- sales@carbosynth.com
- Country
- United Kingdom
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- 6005
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