6-bromoisoquinolin-3-amine
- Product Name
- 6-bromoisoquinolin-3-amine
- CAS No.
- 891785-28-7
- Chemical Name
- 6-bromoisoquinolin-3-amine
- Synonyms
- 6-bromoisoquinolin-3-amine;6-broMo-3-isoquinolinaMine;3-Isoquinolinamine,6-bromo-;3-Amino-6-bromoisoquinoline;3-Amino-6-bromoisoquinoline 97%;6-bromoisoquinolin-3-amine - [B5436];6-bromoisoquinolin-3-amine ISO 9001：2015 REACH;6-Bromoisoquinolin-3-amine, 3-Amino-6-bromo-2-azanaphthalene
- CBNumber
- CB41856163
- Molecular Formula
- C9H7BrN2
- Formula Weight
- 223.07
- MOL File
- 891785-28-7.mol
6-bromoisoquinolin-3-amine Property
- Boiling point:
- 387.6±22.0 °C(Predicted)
- Density
- 1.649±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 4.49±0.38(Predicted)
- form
- solid
- color
- Light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B292405
- Product name
- 6-Bromoisoquinolin-3-amine
- Packaging
- 250mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- FB29230
- Product name
- 6-Bromo-3-isoquinolinamine
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- B11726
- Product name
- 6-Bromoisoquinolin-3-amine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- Y5645
- Product name
- 6-Bromoisoquinolin-3-amine
- Packaging
- 250mg
- Price
- $131
- Updated
- 2021/12/16
- Product number
- FB29230
- Product name
- 6-Bromo-3-isoquinolinamine
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
6-bromoisoquinolin-3-amine Chemical Properties,Usage,Production
Uses
6-Bromoisoquinolin-3-amine is employed in the comprehensive structure-activity relationship studies to identify the allosteric inhibitors that exhibit selective recognition of protein arginine methyltransferase PRMT3 in human cells.
Synthesis
925672-85-1
891785-28-7
General procedure for the synthesis of 6-bromoisoquinolin-3-amine from 1,6-dibromoisoquinolin-3-amine: 1,6-dibromoisoquinolin-3-amine (13.5 g, 45 mmol), ammonium formate (10.8 g, 172 mmol), and tetrakis(triphenylphosphine)palladium(0) (3.45 g, 3.0 mmol) were dissolved in 50 mL of DMF and the mixture was transferred to a 350 mL screw cap flask, sealed and heated at 50 °C for 48 hours. Subsequently, tetrakis(triphenylphosphine)palladium(0) (950 mg) and ammonium formate (3.0 g) were added supplementally to the reaction mixture and heating was continued at 50 °C for 48 hours. After completion of the reaction, the mixture was cooled to room temperature, the solid was collected by filtration, washed with a small amount of DMF and then with ether, and finally dried under vacuum at 50 °C to give the yellow amorphous solid product 6-bromoisoquinolin-3-amine (10.4 g, 90% yield). The product was detected by LCMS (API-ES), m/z: 222.9, 224.9 [M + 1]. 1H NMR (300MHz, DMSO-d6) δppm 8.81 (s, 1H), 7.80 (d, J = 1.6Hz, 1H), 7.73 (d, J = 8.8Hz, 1H), 7.22 (dd, J = 8.6, 1.9 Hz, 1H), 6.55 (s, 1H), 6.12 (s, 2H).
References
[1] Patent: WO2009/11871, 2009, A2. Location in patent: Page/Page column 188; 189
[2] Patent: WO2009/11880, 2009, A2. Location in patent: Page/Page column 159-160
6-bromoisoquinolin-3-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-bromoisoquinolin-3-amine manufacturers
- Product
- 3-Amino-6-bromoisoquinoline 891785-28-7
- Price
- US $244.00-667.00/g
- Min. Order
- 5g
- Purity
- 0.97
- Supply Ability
- 25kg
- Release date
- 2023-12-27
- Product
- 6-bromoisoquinolin-3-amine 891785-28-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23
- Product
- 6-bromoisoquinolin-3-amine 891785-28-7
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2018-12-23