ChemicalBook > CAS DataBase List > 6-bromoisoquinolin-3-amine

6-bromoisoquinolin-3-amine

Product Name: 6-bromoisoquinolin-3-amine
CAS No.: 891785-28-7
Chemical Name: 6-bromoisoquinolin-3-amine
Synonyms: 6-bromoisoquinolin-3-amine;6-broMo-3-isoquinolinaMine;3-Isoquinolinamine,6-bromo-;3-Amino-6-bromoisoquinoline;3-Amino-6-bromoisoquinoline 97%;6-bromoisoquinolin-3-amine - [B5436];6-bromoisoquinolin-3-amine ISO 9001：2015 REACH;6-Bromoisoquinolin-3-amine, 3-Amino-6-bromo-2-azanaphthalene
CBNumber: CB41856163
Molecular Formula: C9H7BrN2
Formula Weight: 223.07
MOL File: 891785-28-7.mol

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6-bromoisoquinolin-3-amine Property

Boiling point:: 387.6±22.0 °C(Predicted)
Density: 1.649±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 4.49±0.38(Predicted)
form: solid
color: Light yellow

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933499090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B292405
Product name: 6-Bromoisoquinolin-3-amine
Packaging: 250mg
Price: $550
Updated: 2021/12/16

Matrix Scientific

Product number: 139077
Product name: 6-Bromoisoquinolin-3-amine
Purity: 95%+
Packaging: 5g
Price: $616
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB29230
Product name: 6-Bromo-3-isoquinolinamine
Packaging: 5G
Price: $650
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-9-X6
Product name: 3-Amino-6-bromoisoquinoline
Purity: 97%
Packaging: 5G
Price: $668
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0044798
Product name: 6-BROMOISOQUINOLIN-3-AMINE
Purity: 95.00%
Packaging: 250MG
Price: $817.62
Updated: 2021/12/16

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6-bromoisoquinolin-3-amine Chemical Properties,Usage,Production

Uses

6-Bromoisoquinolin-3-amine is employed in the comprehensive structure-activity relationship studies to identify the allosteric inhibitors that exhibit selective recognition of protein arginine methyltransferase PRMT3 in human cells.

Synthesis

925672-85-1

891785-28-7

General procedure for the synthesis of 6-bromoisoquinolin-3-amine from 1,6-dibromoisoquinolin-3-amine: 1,6-dibromoisoquinolin-3-amine (13.5 g, 45 mmol), ammonium formate (10.8 g, 172 mmol), and tetrakis(triphenylphosphine)palladium(0) (3.45 g, 3.0 mmol) were dissolved in 50 mL of DMF and the mixture was transferred to a 350 mL screw cap flask, sealed and heated at 50 °C for 48 hours. Subsequently, tetrakis(triphenylphosphine)palladium(0) (950 mg) and ammonium formate (3.0 g) were added supplementally to the reaction mixture and heating was continued at 50 °C for 48 hours. After completion of the reaction, the mixture was cooled to room temperature, the solid was collected by filtration, washed with a small amount of DMF and then with ether, and finally dried under vacuum at 50 °C to give the yellow amorphous solid product 6-bromoisoquinolin-3-amine (10.4 g, 90% yield). The product was detected by LCMS (API-ES), m/z: 222.9, 224.9 [M + 1]. 1H NMR (300MHz, DMSO-d6) δppm 8.81 (s, 1H), 7.80 (d, J = 1.6Hz, 1H), 7.73 (d, J = 8.8Hz, 1H), 7.22 (dd, J = 8.6, 1.9 Hz, 1H), 6.55 (s, 1H), 6.12 (s, 2H).

References

[1] Patent: WO2009/11871, 2009, A2. Location in patent: Page/Page column 188; 189
[2] Patent: WO2009/11880, 2009, A2. Location in patent: Page/Page column 159-160

6-bromoisoquinolin-3-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 6-bromoisoquinolin-3-amine manufacturers

Shanghai UCHEM Inc.

Product: 3-Amino-6-bromoisoquinoline 891785-28-7
Price: US $244.00-667.00/g
Min. Order: 5g
Purity: 0.97
Supply Ability: 25kg
Release date: 2023-12-27

Career Henan Chemical Co

Product: 6-bromoisoquinolin-3-amine 891785-28-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200KG
Release date: 2018-12-23

Career Henan Chemical Co

Product: 6-bromoisoquinolin-3-amine 891785-28-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200KG
Release date: 2018-12-23

891785-28-7, 6-bromoisoquinolin-3-amineRelated Search:

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6-broMo-3-isoquinolinaMine

6-Bromoisoquinolin-3-amine, 3-Amino-6-bromo-2-azanaphthalene

3-Amino-6-bromoisoquinoline

3-Amino-6-bromoisoquinoline 97%

6-bromoisoquinolin-3-amine ISO 9001：2015 REACH

6-bromoisoquinolin-3-amine - [B5436]

891785-28-7

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