6-Bromoindole-3-carboxylic acid

Product Name: 6-Bromoindole-3-carboxylic acid
CAS No.: 101774-27-0
Chemical Name: 6-Bromoindole-3-carboxylic acid
Synonyms: 6-BROMO-1H-INDOLE-3-CARBOXYLIC ACID;6-broMo-3-indole acid;6-bromo-1H-indole-3-carboxylic;6-bromoindole-3-carboxylic acid;6-bromoindolyl-3-carboxylic acid;6-Bromo-1H-indol-3-carboxylic acid;1H-Indole-3-carboxylic acid, 6-broMo-;7024 6-BROMO-1H-INDOLE-3-CARBOXYLIC ACID;6-Bromoindole-3-carboxylic acid, 10 mM in DMSO;6-BROMO-1-(TERT-BUTOXYCARBONYL)-1H-INDOLE-3-CARBOXYLIC ACID
CBNumber: CB7322329
Molecular Formula: C9H6BrNO2
Formula Weight: 240.05
MOL File: 101774-27-0.mol

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6-Bromoindole-3-carboxylic acid Property

Melting point:: 212 °C
Boiling point:: 470.9±25.0 °C(Predicted)
Density: 1.838±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 3.61±0.10(Predicted)
Appearance: pale yellow solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: B696353
Product name: 6-Bromo-1h-indole-3-carboxylicacid
Packaging: 100mg
Price: $45
Updated: 2021/12/16

Apolloscientific

Product number: OR914279
Product name: 6-Bromo-1H-indole-3-carboxylicacid
Purity: 98%
Packaging: 1g
Price: $34
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-9-1V
Product name: 6-Bromo-indole-3-carboxylic acid
Packaging: 1g
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 072255
Product name: 6-Bromo-1H-indole-3-carboxylic acid
Purity: 95+%
Packaging: 1g
Price: $76
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB56690
Product name: 6-Bromo-1H-indole-3-carboxylic acid
Packaging: 500mg
Price: $80
Updated: 2021/12/16

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6-Bromoindole-3-carboxylic acid Chemical Properties,Usage,Production

Uses

6-Bromoindole-3-carboxylic acid is an organic compound that is often used as a starting material for the synthesis of antitumor drugs.

Synthesis

79878-02-7

101774-27-0

General procedure for the synthesis of 6-bromo-1H-indole-3-carboxylic acid from 1-(6-bromo-1H-indol-3-yl)-2,2,2-trifluoroethanone: 1-(6-bromo-1H-indol-3-yl)-2,2,2-trifluoroethanone (1.0 eq., 1.0 g) was mixed with a 20% aqueous sodium hydroxide solution (17 mL) and heated to 100 °C. Stirring was continued at this temperature until the reaction was complete (about 18 hours). After completion of the reaction, the solution was cooled to room temperature and washed twice with dichloromethane. Subsequently, the aqueous solution was acidified with hydrochloric acid to the appropriate pH, the precipitate precipitated was collected by filtration and dried under vacuum to afford the target product 6-bromo-1H-indole-3-carboxylic acid (715 mg, 87% yield).

References

[1] Patent: WO2011/50245, 2011, A1. Location in patent: Page/Page column 81
[2] Patent: EP2548864, 2013, A1. Location in patent: Paragraph 0171
[3] Patent: WO2013/14102, 2013, A1. Location in patent: Page/Page column 26; 31
[4] Patent: US2014/200215, 2014, A1. Location in patent: Paragraph 0978; 0980
[5] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 23, p. 7107 - 7112

6-Bromoindole-3-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Bromoindole-3-carboxylic acid Suppliers

Belgium 1 China 148 Germany 1 India 1 United Kingdom 2 United States 16 Global 169

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China Langchem Inc.

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View Lastest Price from 6-Bromoindole-3-carboxylic acid manufacturers

ZHUHAI HRD PHARMACEUTICAL CO., LTD.

Product: 6-Bromoindole-3-carboxylic acid 101774-27-0
Price: US $0.00-0.00/mg/ bottle
Min. Order: 100mg/ bottle
Purity: 95%-98%
Supply Ability: Quantity can be customized
Release date: 2023-08-31

Career Henan Chemical Co

Product: 6-Bromoindole-3-carboxylic acid 101774-27-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 95-99%
Supply Ability: 1MT/month
Release date: 2019-07-31

101774-27-0, 6-Bromoindole-3-carboxylic acidRelated Search:

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6-BROMO-1H-INDOLE-3-CARBOXYLIC ACID

6-BROMO-1-(TERT-BUTOXYCARBONYL)-1H-INDOLE-3-CARBOXYLIC ACID

6-bromoindole-3-carboxylic acid

6-bromo-1H-indole-3-carboxylic

7024 6-BROMO-1H-INDOLE-3-CARBOXYLIC ACID

1H-Indole-3-carboxylic acid, 6-broMo-

6-broMo-3-indole acid

6-bromoindolyl-3-carboxylic acid

6-Bromoindole-3-carboxylic acid, 10 mM in DMSO

6-Bromo-1H-indol-3-carboxylic acid

101774-27-0

C9H5O2BrN

Indole