2-CHLORO-6-METHOXYNICOTINALDEHYDE
- Product Name
- 2-CHLORO-6-METHOXYNICOTINALDEHYDE
- CAS No.
- 95652-80-5
- Chemical Name
- 2-CHLORO-6-METHOXYNICOTINALDEHYDE
- Synonyms
- 2-CHLORO-6-METHOXYNICOTINALDEHYDE;2-CHLORO-6-METHOXYPYRIDINE-3-CARBALDEHYDE;2-chloro-6-methoxy-3-pyridine-carboxaldehyde;3-Pyridinecarboxaldehyde, 2-chloro-6-methoxy-
- CBNumber
- CB22454427
- Molecular Formula
- C7H6ClNO2
- Formula Weight
- 171.58
- MOL File
- 95652-80-5.mol
2-CHLORO-6-METHOXYNICOTINALDEHYDE Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C597908
- Product name
- 2-Chloro-6-methoxynicotinaldehyde
- Packaging
- 100mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- 6514AC
- Product name
- 2-Chloro-6-methoxynicotinaldehyde
- Packaging
- 250mg
- Price
- $243
- Updated
- 2021/12/16
- Product number
- HCH0363613
- Product name
- 2-CHLORO-6-METHOXYNICOTINALDEHYDE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $347.55
- Updated
- 2021/12/16
- Product number
- CD11003597
- Product name
- 2-Chloro-6-methoxynicotinaldehyde
- Purity
- 98%
- Packaging
- 1g
- Price
- $356
- Updated
- 2021/12/16
- Product number
- CM130147
- Product name
- 2-chloro-6-methoxynicotinaldehyde
- Purity
- 98%
- Packaging
- 5g
- Price
- $996
- Updated
- 2021/12/16
2-CHLORO-6-METHOXYNICOTINALDEHYDE Chemical Properties,Usage,Production
Synthesis
17228-64-7
68-12-2
95652-80-5
Over 5 min at -78 °C, 2-chloro-6-methoxypyridine (4.14 mL, 34.8 mmol) was slowly added dropwise to a mixture of tert-butyllithium (1.7 M pentane solution, 22.5 mL, 38.3 mmol) and 69 mL THF. The reaction mixture was stirred continuously at -78 °C for 1 h. Subsequently, N,N-dimethylformamide (3.5 mL, 45.0 mmol) was added and stirring was continued at -78 °C for 1.5 h. The reaction was completed with the addition of N,N-dimethylformamide (3.5 mL, 45.0 mmol). Upon completion of the reaction, the reaction was quenched by the addition of glacial acetic acid (4.0 mL, 69.0 mmol) and slowly warmed to room temperature over 30 minutes. Ether (200 mL) was added to dilute the reaction mixture, and the organic phase was washed sequentially with saturated aqueous sodium bicarbonate (50 mL) and brine (50 mL) and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure and the crude product obtained was recrystallized from hexane to give 4.6 g (76% yield) of 2-chloro-6-methoxynicotinaldehyde as a light yellow solid, melting point: 67.0-68.0 °C. The product was analyzed by 1H NMR (1H NMR). The product was confirmed by 1H NMR (300 MHz, CDCl3): δ 10.29 (d, J = 0.8 Hz, 1H), 8.05 (d, J = 7.9 Hz, 1H), 7.02 (dd, J1 = 7.9 Hz, J2 = 0.8 Hz, 1H), 4.08 (s, 3H); 13C NMR (75 MHz, CDCl3): δ 188.0, 164.2, 154.6, 140.0, 117.6, 117.5, 54.8; IR (ATR, cm-1): 3103, 2869, 1683, 1567, 1468, 1378, 1273, 1005.
References
[1] Patent: WO2017/118762, 2017, A1. Location in patent: Page/Page column 40; 41
2-CHLORO-6-METHOXYNICOTINALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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