METHYL 2-CHLORO-6-METHOXYNICOTINATE
- Product Name
- METHYL 2-CHLORO-6-METHOXYNICOTINATE
- CAS No.
- 95652-77-0
- Chemical Name
- METHYL 2-CHLORO-6-METHOXYNICOTINATE
- Synonyms
- METHYL 2-CHLORO-6-METHOXYNICOTINATE;Methyl 2-chloro-6-methoxynicatinate;Methyl 2-chloro-6-methoxynicotinate 97%;Methyl 2-chloro-6-Methoxypyridine-3-carboxylate;3-Pyridinecarboxylic acid, 2-chloro-6-Methoxy-, Methyl ester;Methyl 2-chloro-6-methoxypyridine-3-carboxylate, 2-Chloro-6-methoxy-3-(methoxycarbonyl)pyridine;Methyl 2-chloro-6-methoxypyridine-3-carboxylate, 2-Chloro-3-(methoxycarbonyl)-6-methoxypyridine
- CBNumber
- CB0431653
- Molecular Formula
- C8H8ClNO3
- Formula Weight
- 201.61
- MOL File
- 95652-77-0.mol
METHYL 2-CHLORO-6-METHOXYNICOTINATE Property
- Melting point:
- 67-69°
- Boiling point:
- 276.8±35.0 °C(Predicted)
- Density
- 1.288±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- -1.13±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C8H8ClNO3/c1-12-6-4-3-5(7(9)10-6)8(11)13-2/h3-4H,1-2H3
- InChIKey
- WDMMBHZPESWUCL-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(OC)=CC=C1C(OC)=O
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
N-Bromosuccinimide Price
- Product number
- M623903
- Product name
- Methyl2-Chloro-6-methoxynicotinate
- Packaging
- 1g
- Price
- $190
- Updated
- 2021/12/16
- Product number
- 4H23-5-Z4
- Product name
- Methyl 2-chloro-6-methoxynicotinate
- Packaging
- 1g
- Price
- $215
- Updated
- 2021/12/16
- Product number
- Y4843
- Product name
- Methyl2-chloro-6-methoxypyridine-3-carboxylate
- Packaging
- 100mg
- Price
- $82
- Updated
- 2021/12/16
- Product number
- 4H23-5-Z4
- Product name
- Methyl 2-chloro-6-methoxynicotinate
- Packaging
- 250mg
- Price
- $87
- Updated
- 2021/12/16
- Product number
- 046234
- Product name
- Methyl 2-chloro-6-methoxynicotinate
- Purity
- >95%
- Packaging
- 1g
- Price
- $141
- Updated
- 2021/12/16
METHYL 2-CHLORO-6-METHOXYNICOTINATE Chemical Properties,Usage,Production
Uses
Methyl 2-Chloro-6-methoxynicotinate is used in preparation of Aryl-aniline and Heteroaryl-Aniline compounds useful in topical formulations for treatment of skin diseases.
Synthesis Reference(s)
Journal of Medicinal Chemistry, 46, p. 702, 2003 DOI: 10.1021/jm020270n
Synthesis
38025-90-0
74-88-4
95652-77-0
General Steps: 1. 2-Chloro-6-hydroxynicotinic acid (3.00 g, 17.3 mmol) and chloroform (30 mL) were added to a 50 mL round-bottomed flask and stirred until completely dissolved. 2. Silver carbonate (11.0 g, 39.8 mmol) and methyl iodide (3.77 mL, 60.5 mmol) were added sequentially to the above solution. 3. The reaction mixture was stirred at 50 °C for 3 hours and the reaction was monitored by TLC. 4. 4. After completion of the reaction, the mixture was vacuum filtered and the filter cake was washed with chloroform. 5. The filtrate and washings were combined and concentrated under reduced pressure in a rotary evaporator to give the crude product. 6. The crude product was purified by fast column chromatography (eluent: 0-100% ethyl acetate/heptane gradient elution) and the target fraction was collected. 7. The target fraction was concentrated under pressure to afford methyl 2-chloro-6-methoxypyridine-3-carboxylate (2.42 g, 69% yield) as a white powder. 8. The product was purified by LCMS (0-100% ethyl acetate/heptane gradient elution). 8. The product was characterized by LCMS (Method D): retention time 1.13 min, m/z = 202 (M + 1).
References
[1] Patent: WO2017/147102, 2017, A1. Location in patent: Paragraph 00376-00377
METHYL 2-CHLORO-6-METHOXYNICOTINATE Preparation Products And Raw materials
Raw materials
Preparation Products
METHYL 2-CHLORO-6-METHOXYNICOTINATE Suppliers
- Tel
- 15921357166
- 27960385@qq.com
- Country
- China
- ProdList
- 69
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- (86) 21 51969655
- Fax
- (86) 21 51969655， QQ：33109286， 263541193
- Country
- China
- ProdList
- 487
- Advantage
- 22
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 0513-85921823 18662920231
- Fax
- 86-513-85012876
- sales@ntminyanmedical.com
- Country
- China
- ProdList
- 4113
- Advantage
- 58
- Tel
- 021-61478794
- Fax
- 021-61478794
- sales@hcshhai.com
- Country
- China
- ProdList
- 9793
- Advantage
- 50
View Lastest Price from METHYL 2-CHLORO-6-METHOXYNICOTINATE manufacturers
- Product
- METHYL 2-CHLORO-6-METHOXYNICOTINATE 95652-77-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-11