ChemicalBook > CAS DataBase List > METHYL 2-CHLORO-6-METHOXYNICOTINATE

METHYL 2-CHLORO-6-METHOXYNICOTINATE

Product Name: METHYL 2-CHLORO-6-METHOXYNICOTINATE
CAS No.: 95652-77-0
Chemical Name: METHYL 2-CHLORO-6-METHOXYNICOTINATE
Synonyms: METHYL 2-CHLORO-6-METHOXYNICOTINATE;Methyl 2-chloro-6-methoxynicatinate;Methyl 2-chloro-6-methoxynicotinate 97%;Methyl 2-chloro-6-Methoxypyridine-3-carboxylate;3-Pyridinecarboxylic acid, 2-chloro-6-Methoxy-, Methyl ester;Methyl 2-chloro-6-methoxypyridine-3-carboxylate, 2-Chloro-6-methoxy-3-(methoxycarbonyl)pyridine;Methyl 2-chloro-6-methoxypyridine-3-carboxylate, 2-Chloro-3-(methoxycarbonyl)-6-methoxypyridine
CBNumber: CB0431653
Molecular Formula: C8H8ClNO3
Formula Weight: 201.61
MOL File: 95652-77-0.mol

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METHYL 2-CHLORO-6-METHOXYNICOTINATE Property

Melting point:: 67-69°
Boiling point:: 276.8±35.0 °C(Predicted)
Density: 1.288±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: -1.13±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C8H8ClNO3/c1-12-6-4-3-5(7(9)10-6)8(11)13-2/h3-4H,1-2H3
InChIKey: WDMMBHZPESWUCL-UHFFFAOYSA-N
SMILES: C1(Cl)=NC(OC)=CC=C1C(OC)=O

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Safety

HazardClass: IRRITANT
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: M623903
Product name: Methyl2-Chloro-6-methoxynicotinate
Packaging: 1g
Price: $190
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-5-Z4
Product name: Methyl 2-chloro-6-methoxynicotinate
Packaging: 1g
Price: $215
Updated: 2021/12/16

AK Scientific

Product number: Y4843
Product name: Methyl2-chloro-6-methoxypyridine-3-carboxylate
Packaging: 100mg
Price: $82
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-5-Z4
Product name: Methyl 2-chloro-6-methoxynicotinate
Packaging: 250mg
Price: $87
Updated: 2021/12/16

Matrix Scientific

Product number: 046234
Product name: Methyl 2-chloro-6-methoxynicotinate
Purity: >95%
Packaging: 1g
Price: $141
Updated: 2021/12/16

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METHYL 2-CHLORO-6-METHOXYNICOTINATE Chemical Properties,Usage,Production

Uses

Methyl 2-Chloro-6-methoxynicotinate is used in preparation of Aryl-aniline and Heteroaryl-Aniline compounds useful in topical formulations for treatment of skin diseases.

Synthesis Reference(s)

Journal of Medicinal Chemistry, 46, p. 702, 2003 DOI: 10.1021/jm020270n

Synthesis

38025-90-0

74-88-4

95652-77-0

General Steps: 1. 2-Chloro-6-hydroxynicotinic acid (3.00 g, 17.3 mmol) and chloroform (30 mL) were added to a 50 mL round-bottomed flask and stirred until completely dissolved. 2. Silver carbonate (11.0 g, 39.8 mmol) and methyl iodide (3.77 mL, 60.5 mmol) were added sequentially to the above solution. 3. The reaction mixture was stirred at 50 °C for 3 hours and the reaction was monitored by TLC. 4. 4. After completion of the reaction, the mixture was vacuum filtered and the filter cake was washed with chloroform. 5. The filtrate and washings were combined and concentrated under reduced pressure in a rotary evaporator to give the crude product. 6. The crude product was purified by fast column chromatography (eluent: 0-100% ethyl acetate/heptane gradient elution) and the target fraction was collected. 7. The target fraction was concentrated under pressure to afford methyl 2-chloro-6-methoxypyridine-3-carboxylate (2.42 g, 69% yield) as a white powder. 8. The product was purified by LCMS (0-100% ethyl acetate/heptane gradient elution). 8. The product was characterized by LCMS (Method D): retention time 1.13 min, m/z = 202 (M + 1).

References

[1] Patent: WO2017/147102, 2017, A1. Location in patent: Paragraph 00376-00377

METHYL 2-CHLORO-6-METHOXYNICOTINATE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from METHYL 2-CHLORO-6-METHOXYNICOTINATE manufacturers

Career Henan Chemical Co

Product: METHYL 2-CHLORO-6-METHOXYNICOTINATE 95652-77-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-11

95652-77-0, METHYL 2-CHLORO-6-METHOXYNICOTINATERelated Search:

Tetramethylsilane Mercury 2-CHLORO-6-METHOXYNICOTINALDEHYDE METHYL 2-CHLORO-6-METHOXYNICOTINATE 2-CHLORO-6-METHOXYNICOTINIC ACID 2-Chloro-6-hydroxynicotinic acid

METHYL 2-CHLORO-6-METHOXYNICOTINATE

Methyl 2-chloro-6-methoxypyridine-3-carboxylate, 2-Chloro-3-(methoxycarbonyl)-6-methoxypyridine

Methyl 2-chloro-6-Methoxypyridine-3-carboxylate

3-Pyridinecarboxylic acid, 2-chloro-6-Methoxy-, Methyl ester

Methyl 2-chloro-6-methoxypyridine-3-carboxylate, 2-Chloro-6-methoxy-3-(methoxycarbonyl)pyridine

Methyl 2-chloro-6-methoxynicatinate

Methyl 2-chloro-6-methoxynicotinate 97%

95652-77-0