2-Chloro-6-hydroxynicotinic acid
Uses- Product Name
- 2-Chloro-6-hydroxynicotinic acid
- CAS No.
- 38025-90-0
- Chemical Name
- 2-Chloro-6-hydroxynicotinic acid
- Synonyms
- 2-Chloro-6-hydroxynicotinicaci;2-Chloro-6-Hydroxynicotinic Acid;2-CHLORO-6-HYDROXYNICOTINIC ACID,98%;2-Chloro-6-hydroxynicotinic Acid >2-Chloro-6-hydroxypyridine-3-carboxylic acid;2-Chloro-6-hydroxy-3-pyridinecarboxylic Acid;2-Chloro-6-hydroxynicotinic acid ISO 9001：2015 REACH;3-Pyridinecarboxylic acid, 2-chloro-1,6-dihydro-6-oxo-
- CBNumber
- CB11459495
- Molecular Formula
- C6H4ClNO3
- Formula Weight
- 173.55
- MOL File
- 38025-90-0.mol
2-Chloro-6-hydroxynicotinic acid Property
- Melting point:
- 302°C(lit.)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- form
- powder to crystal
- color
- White to Light yellow to Light red
- InChI
- InChI=1S/C6H4ClNO3/c7-5-3(6(10)11)1-2-4(9)8-5/h1-2H,(H,8,9)(H,10,11)
- InChIKey
- BSCFFOOWFVZSSK-UHFFFAOYSA-N
- SMILES
- C1(Cl)NC(=O)C=CC=1C(O)=O
- CAS DataBase Reference
- 38025-90-0
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- C2398
- Product name
- 2-Chloro-6-hydroxynicotinic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $56
- Updated
- 2025/07/31
- Product number
- C2398
- Product name
- 2-Chloro-6-hydroxynicotinic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $193
- Updated
- 2025/07/31
- Product number
- C422095
- Product name
- 2-Chloro-6-hydroxynicotinic Acid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C422095
- Product name
- 2-Chloro-6-hydroxynicotinic Acid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- C422095
- Product name
- 2-Chloro-6-hydroxynicotinic Acid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
2-Chloro-6-hydroxynicotinic acid Chemical Properties,Usage,Production
Uses
2-Chloro-6-hydroxynicotinic acid, as a pharmaceutical intermediate, can be used to prepare N-(2-(2-fluoro-4-iodophenylamino)-1,5-dimethyl-6-oxo-1,6-dihydropyridin-3-yl)cyclopropanesulfonamide, which is a MEK inhibitor.
Chemical Properties
Off-white powder
Synthesis
38496-18-3
38025-90-0
The general procedure for the synthesis of 2-chloro-6-hydroxynicotinic acid from 2,6-dichloronicotinic acid is as follows: 1. 2,6-dichloronicotinic acid (25 g, 130 mmol) and NaOH solution (325 mL, 2N) were added to a 500 mL round bottom flask. 2. The reaction mixture was refluxed at 129°C for 4 hours. 3. Upon completion of the reaction, the mixture was cooled to 0°C. 4. The reaction mixture was acidified to room temperature with 6N aqueous HCl solution. 5. The resulting precipitate was collected by filtration. 6. The precipitate was dried under reduced pressure to give 2-chloro-6-hydroxynicotinic acid (19.87 g, 88% yield).
References
[1] Patent: WO2010/108652, 2010, A1. Location in patent: Page/Page column 97
[2] Patent: WO2008/125820, 2008, A1. Location in patent: Page/Page column 33
[3] Patent: CN108314645, 2018, A. Location in patent: Paragraph 0094; 0095; 0096; 0097
2-Chloro-6-hydroxynicotinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Chloro-6-hydroxynicotinic acid manufacturers
- Product
- 2-Chloro-6-hydroxynicotinic acid 38025-90-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-18
- Product
- 2-Chloro-6-hydroxynicotinic acid 38025-90-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-26
- Product
- 2-Chloro-6-hydroxynicotinic acid 38025-90-0
- Price
- US $1.00/kg
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-12-21