ChemicalBook > CAS DataBase List > 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID
5-METHOXYPYRAZINE-2-CARBOXYLIC ACID
- Product Name
- 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID
- CAS No.
- 40155-42-8
- Chemical Name
- 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID
- Synonyms
- 5-Methoxypyrazine-2-carboxylic;5-Methoxy-pyrazinecarboxylic acid;Pyrazinecarboxylic acid, 5-methoxy-;5-METHOXYPYRAZINE-2-CARBOXYLIC ACID;5-Methoxy-2-pyrazinecarboxylic acid;2-Pyrazinecarboxylicacid, 5-Methoxy-;5-Methoxypyrazine-2-carboxylic acid 95%;2-Carboxy-5-methoxypyrazine, 2-Carboxy-5-methoxy-1,4-diazine
- CBNumber
- CB22454568
- Molecular Formula
- C6H6N2O3
- Formula Weight
- 154.12
- MOL File
- 40155-42-8.mol
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5-METHOXYPYRAZINE-2-CARBOXYLIC ACID Property
- Melting point:
- 197.5-199.5℃
- Boiling point:
- 296.8±35.0 °C(Predicted)
- Density
- 1.371±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 3.18±0.10(Predicted)
- form
- Solid
- color
- Light yellow to Brown to Dark green
- InChI
- InChI=1S/C6H6N2O3/c1-11-5-3-7-4(2-8-5)6(9)10/h2-3H,1H3,(H,9,10)
- InChIKey
- YVGVOPNUEFTVQO-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC=C(OC)N=C1
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Safety
- HS Code
- 2933998090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
TCI Chemical
- Product number
- M3181
- Product name
- 5-Methoxypyrazine-2-carboxylic Acid
- Packaging
- 200MG
- Price
- $55
- Updated
- 2025/07/31
TCI Chemical
- Product number
- M3181
- Product name
- 5-Methoxypyrazine-2-carboxylic Acid
- Packaging
- 1G
- Price
- $188
- Updated
- 2025/07/31
TRC
- Product number
- M223058
- Product name
- 5-Methoxypyrazine-2-carboxylic Acid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H21-1-Q7
- Product name
- 5-Methoxypyrazine-2-carboxylic acid
- Packaging
- 1g
- Price
- $164
- Updated
- 2021/12/16
AK Scientific
- Product number
- J50883
- Product name
- 5-Methoxypyrazine-2-carboxylic Acid
- Packaging
- 25g
- Price
- $273
- Updated
- 2021/12/16
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5-METHOXYPYRAZINE-2-CARBOXYLIC ACID Chemical Properties,Usage,Production
Synthesis
124-41-4
36070-80-1
40155-42-8
Step 2: Preparation of 5-methoxypyrazine-2-carboxylic acid To a solution of 5-chloropyrazine-2-carboxylic acid (7 g, 44.15 mmol) in methanol (55 mL) was added concentrated sulfuric acid (0.4 mL) and heated to reflux for 4 hours at 65 °C. Upon completion of the reaction, the reaction mixture was cooled to room temperature and diluted with methanol (15 mL). Subsequently, a methanolic solution of sodium methanolate (8.58 g, 158.94 mmol, 35 mL) was slowly added and the reaction mixture was stirred for 30 min at room temperature. Next, a 30 mL aqueous solution of sodium hydroxide (2.825 g, 70.643 mmol) was added to the reaction mixture, followed by 40 mL of water. The reaction mixture was heated at 40 °C for 1 h, followed by concentration under reduced pressure to remove methanol. The residue was diluted with water and the pH was adjusted to 2-3 with 38% aqueous hydrochloric acid and then extracted with ethyl acetate (600 mL x 3). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 5-methoxypyrazine-2-carboxylic acid (6.43 g, 94% yield) as an orange solid. Mass spectrometry analysis: calculated value [M + H]+: 155.04; measured value [M + H]+: 155.1.
References
[1] Patent: WO2015/48507, 2015, A1. Location in patent: Paragraph 0171
5-METHOXYPYRAZINE-2-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID manufacturers
Career Henan Chemical Co
- Product
- 5-METHOXYPYRAZINE-2-CARBOXYLIC ACID 40155-42-8
- Price
- US $2.00/KG
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- ask
- Release date
- 2020-01-07
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