1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE

Product Name: 1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE
CAS No.: 112108-73-3
Chemical Name: 1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE
Synonyms: 2-Chloro-4-fluoro-5-nitrotoluene;2-Chloro-4-fluoro-5-nitrotoluene,97%;4-Chloro-2-fluoro-5-methylnitrobenzene;1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE;Benzene, 1-chloro-5-fluoro-2-Methyl-4-nitro-;1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE ISO 9001：2015 REACH;4-Chloro-2-fluoro-5-methylnitrobenzene, 1-Chloro-5-fluoro-2-methyl-4-nitrobenzene
CBNumber: CB22457963
Molecular Formula: C7H5ClFNO2
Formula Weight: 189.57
MOL File: 112108-73-3.mol

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1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE Property

Melting point:: 34-36℃
Boiling point:: 268℃
Density: 1.417
Flash point:: 116℃
storage temp.: Sealed in dry,Room Temperature
form: Powder
color: Yellow
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C7H5ClFNO2/c1-4-2-7(10(11)12)6(9)3-5(4)8/h2-3H,1H3
InChIKey: YXVJHZWHPLOEAP-UHFFFAOYSA-N
SMILES: C1(Cl)=CC(F)=C([N+]([O-])=O)C=C1C

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Safety

HazardClass: 6.1
HS Code: 2904990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: CVT00038
Product name: 2-Chloro-4-fluoro-5-nitrotoluene
Packaging: 1 g
Price: $95.2
Updated: 2025/07/31

TCI Chemical

Product number: C3273
Product name: 2-Chloro-4-fluoro-5-nitrotoluene
Purity: >98.0%(GC)
Packaging: 5g
Price: $74
Updated: 2025/07/31

TCI Chemical

Product number: C3273
Product name: 2-Chloro-4-fluoro-5-nitrotoluene
Purity: >98.0%(GC)
Packaging: 25g
Price: $219
Updated: 2025/07/31

TRC

Product number: C366770
Product name: 2-Chloro-4-fluoro-5-nitrotoluene
Packaging: 5g
Price: $165
Updated: 2021/12/16

Apolloscientific

Product number: PC27850
Product name: 2-Chloro-4-fluoro-5-nitrotoluene
Packaging: 5g
Price: $14
Updated: 2021/12/16

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1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE Chemical Properties,Usage,Production

Uses

2-Chloro-4-fluoro-5-nitrotoluene, is used as a pharmaceutical intermediate. It is also used as Ceritinib intermediate.

Synthesis

452-73-3

112108-73-3

The general procedure for the synthesis of 2-chloro-4-fluoro-5-nitrotoluene from 2-chloro-4-fluorotoluene was as follows: to a stirred concentrated solution of 2-chloro-4-fluorotoluene (2.000 g, 1.383 mmol, Aldrich, direct use), concentrated sulfuric acid (15.0 mL) was slowly added at 0°C, followed by a single addition of potassium nitrate (KNO3, 1.400 g , 1.385 mmol). The reaction mixture gradually changed to a light yellow solution, which was then warmed to 28 °C and stirred at this temperature overnight. Upon completion of the reaction, the mixture was quenched by careful pouring into ice (100 g) and extracted with ethyl acetate (2 x 100 mL). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to remove the solvent. The resulting oily product was further dried under vacuum to give 2.085 g (80% yield) of the target compound 2-chloro-4-fluoro-5-nitrotoluene as an oil, which was used directly in the next step of the reaction.1H NMR (CDCl3) data were as follows: δ 2.422 (s, 3H), 7.325 (d, 1H, J=10.2 Hz), 7.973 (d, 1H, J= 5.2Hz).

References

[1] Patent: WO2005/82853, 2005, A1. Location in patent: Page/Page column 210-211
[2] Patent: WO2005/75425, 2005, A2. Location in patent: Page/Page column 184-185
[3] Patent: WO2005/82862, 2005, A2. Location in patent: Page/Page column 136
[4] Journal of Medicinal Chemistry, 2013, vol. 56, # 14, p. 5675 - 5690
[5] Patent: KR2016/147358, 2016, A. Location in patent: Paragraph 0226-0228

1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE Suppliers

Americas 1 China 168 Europe 1 India 4 Japan 1 United Kingdom 3 United States 12 Global 190

Fuxin Yinghui High tech Materials Technology Co., Ltd

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View Lastest Price from 1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE manufacturers

Henan Fengda Chemical Co., Ltd

Product: 2-Chloro-4-fluoro-5-nitrotoluene 112108-73-3
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-13

Shaanxi Dideu Medichem Co. Ltd

Product: 2-Chloro-4-fluoro-5-nitrotoluene 112108-73-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%+
Supply Ability: 100 tons
Release date: 2020-01-13

Career Henan Chemical Co

Product: 1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE 112108-73-3
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-07-30

112108-73-3, 1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENERelated Search:

meperfluthrin 2-fluoro-4-chlorobenzoic acid 2-Chloro-5-fluoropyrimidine METHYL 2-CHLORO-4-FLUORO-5-NITROBENZOATE 2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID 2-CHLORO-4-FLUORO-5-NITROBENZOYL CHLORIDE 2-CHLORO-4-FLUORO-5-METHYL ANILINE 4-Chloro-2-fluoronitrobenzene 1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE

2-Chloro-4-fluoro-5-nitrotoluene

1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE

Benzene, 1-chloro-5-fluoro-2-Methyl-4-nitro-

4-Chloro-2-fluoro-5-methylnitrobenzene, 1-Chloro-5-fluoro-2-methyl-4-nitrobenzene

2-Chloro-4-fluoro-5-nitrotoluene,97%

4-Chloro-2-fluoro-5-methylnitrobenzene

1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE ISO 9001：2015 REACH

112108-73-3

112108-73-7