ChemicalBook > CAS DataBase List > 1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE

1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE

Product Name
1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE
CAS No.
112108-73-3
Chemical Name
1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE
Synonyms
2-Chloro-4-fluoro-5-nitrotoluene;2-Chloro-4-fluoro-5-nitrotoluene,97%;4-Chloro-2-fluoro-5-methylnitrobenzene;1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE;Benzene, 1-chloro-5-fluoro-2-Methyl-4-nitro-;1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE ISO 9001：2015 REACH;4-Chloro-2-fluoro-5-methylnitrobenzene, 1-Chloro-5-fluoro-2-methyl-4-nitrobenzene
CBNumber
CB22457963
Molecular Formula
C7H5ClFNO2
Formula Weight
189.57
MOL File
112108-73-3.mol
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1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE Property

Melting point:
34-36℃
Boiling point:
268℃
Density 
1.417
Flash point:
116℃
storage temp. 
Sealed in dry,Room Temperature
form 
Powder
color 
Yellow
Water Solubility 
Slightly soluble in water.
InChI
InChI=1S/C7H5ClFNO2/c1-4-2-7(10(11)12)6(9)3-5(4)8/h2-3H,1H3
InChIKey
YXVJHZWHPLOEAP-UHFFFAOYSA-N
SMILES
C1(Cl)=CC(F)=C([N+]([O-])=O)C=C1C
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Safety

HazardClass 
6.1
HS Code 
2904990090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CVT00038
Product name
2-Chloro-4-fluoro-5-nitrotoluene
Packaging
1 g
Price
$95.2
Updated
2025/07/31
TCI Chemical
Product number
C3273
Product name
2-Chloro-4-fluoro-5-nitrotoluene
Purity
>98.0%(GC)
Packaging
5g
Price
$74
Updated
2025/07/31
TCI Chemical
Product number
C3273
Product name
2-Chloro-4-fluoro-5-nitrotoluene
Purity
>98.0%(GC)
Packaging
25g
Price
$219
Updated
2025/07/31
TRC
Product number
C366770
Product name
2-Chloro-4-fluoro-5-nitrotoluene
Packaging
5g
Price
$165
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC37702
Product name
2-Chloro-4-fluoro-5-nitrotoluene
Packaging
10g
Price
$200
Updated
2021/12/16
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1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE Chemical Properties,Usage,Production

Uses

2-Chloro-4-fluoro-5-nitrotoluene, is used as a pharmaceutical intermediate. It is also used as Ceritinib intermediate.

Synthesis

452-73-3

112108-73-3

The general procedure for the synthesis of 2-chloro-4-fluoro-5-nitrotoluene from 2-chloro-4-fluorotoluene was as follows: to a stirred concentrated solution of 2-chloro-4-fluorotoluene (2.000 g, 1.383 mmol, Aldrich, direct use), concentrated sulfuric acid (15.0 mL) was slowly added at 0°C, followed by a single addition of potassium nitrate (KNO3, 1.400 g , 1.385 mmol). The reaction mixture gradually changed to a light yellow solution, which was then warmed to 28 °C and stirred at this temperature overnight. Upon completion of the reaction, the mixture was quenched by careful pouring into ice (100 g) and extracted with ethyl acetate (2 x 100 mL). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure to remove the solvent. The resulting oily product was further dried under vacuum to give 2.085 g (80% yield) of the target compound 2-chloro-4-fluoro-5-nitrotoluene as an oil, which was used directly in the next step of the reaction.1H NMR (CDCl3) data were as follows: δ 2.422 (s, 3H), 7.325 (d, 1H, J=10.2 Hz), 7.973 (d, 1H, J= 5.2Hz).

References

[1] Patent: WO2005/82853, 2005, A1. Location in patent: Page/Page column 210-211
[2] Patent: WO2005/75425, 2005, A2. Location in patent: Page/Page column 184-185
[3] Patent: WO2005/82862, 2005, A2. Location in patent: Page/Page column 136
[4] Journal of Medicinal Chemistry, 2013, vol. 56, # 14, p. 5675 - 5690
[5] Patent: KR2016/147358, 2016, A. Location in patent: Paragraph 0226-0228

1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE Suppliers

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View Lastest Price from 1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE manufacturers

Henan Fengda Chemical Co., Ltd
Product
2-Chloro-4-fluoro-5-nitrotoluene 112108-73-3
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-13
Shaanxi Dideu Medichem Co. Ltd
Product
2-Chloro-4-fluoro-5-nitrotoluene 112108-73-3
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%+
Supply Ability
100 tons
Release date
2020-01-13
Career Henan Chemical Co
Product
1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE 112108-73-3
Price
US $100.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
100KG
Release date
2018-07-30

112108-73-3, 1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENERelated Search:

meperfluthrin 2-fluoro-4-chlorobenzoic acid 2-Chloro-5-fluoropyrimidine METHYL 2-CHLORO-4-FLUORO-5-NITROBENZOATE 2-CHLORO-4-FLUORO-5-NITROBENZOIC ACID 2-CHLORO-4-FLUORO-5-NITROBENZOYL CHLORIDE 2-CHLORO-4-FLUORO-5-METHYL ANILINE 4-Chloro-2-fluoronitrobenzene 1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE

  • 2-Chloro-4-fluoro-5-nitrotoluene
  • 1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE
  • Benzene, 1-chloro-5-fluoro-2-Methyl-4-nitro-
  • 4-Chloro-2-fluoro-5-methylnitrobenzene, 1-Chloro-5-fluoro-2-methyl-4-nitrobenzene
  • 2-Chloro-4-fluoro-5-nitrotoluene,97%
  • 4-Chloro-2-fluoro-5-methylnitrobenzene
  • 1-CHLORO-5-FLUORO-2-METHYL-4-NITRO-BENZENE ISO 9001：2015 REACH
  • 112108-73-3
  • 112108-73-7