2-CHLORO-6-FLUOROQUINAZOLIN-4(3H)-ONE

Product Name: 2-CHLORO-6-FLUOROQUINAZOLIN-4(3H)-ONE
CAS No.: 769158-12-5
Chemical Name: 2-CHLORO-6-FLUOROQUINAZOLIN-4(3H)-ONE
Synonyms: 2-chloro-6-fluoroquinazolin-;2-chloro-6-fluoroquinazolin-4-ol;2-chloro-6-fluoro-4(3H)-Quinazolinone;2-CHLORO-6-FLUOROQUINAZOLIN-4(3H)-ONE;2-Chloro-6-fluoro-4(1H)-quinazolinone;4(3H)-Quinazolinone, 2-chloro-6-fluoro-;2-chloro-6-fluoro-3,4-dihydroquinazolin-4-one
CBNumber: CB22458076
Molecular Formula: C8H4ClFN2O
Formula Weight: 198.58
MOL File: 769158-12-5.mol

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2-CHLORO-6-FLUOROQUINAZOLIN-4(3H)-ONE Property

Boiling point:: 339.8±44.0 °C(Predicted)
Density: 1.61±0.1 g/cm3 (20 ºC 760 Torr)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -3.53±0.20(Predicted)

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Safety

HazardClass: IRRITANT
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C585228
Product name: 2-Chloro-6-fluoroquinazolin-4(3h)-one
Packaging: 100mg
Price: $150
Updated: 2021/12/16

AK Scientific

Product number: X6335
Product name: 2-Chloro-6-fluoroquinazolin-4(3H)-one
Packaging: 250mg
Price: $170
Updated: 2021/12/16

Apolloscientific

Product number: PC904676
Product name: 2-Chloro-6-fluoroquinazolin-4(3H)-one
Purity: 95%
Packaging: 250mg
Price: $225
Updated: 2021/12/16

Apolloscientific

Product number: PC904676
Product name: 2-Chloro-6-fluoroquinazolin-4(3H)-one
Purity: 95%
Packaging: 1g
Price: $470
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0363604
Product name: 2-CHLORO-6-FLUOROQUINAZOLIN-4(3H)-ONE
Purity: 95.00%
Packaging: 5MG
Price: $499.74
Updated: 2021/12/16

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2-CHLORO-6-FLUOROQUINAZOLIN-4(3H)-ONE Chemical Properties,Usage,Production

Synthesis

134517-57-0

769158-12-5

The general procedure for the synthesis of 2-chloro-4-oxo-6-fluoroquinazoline from 2,4-dichloro-6-fluoroquinazoline was as follows: 2,4-dichloro-6-fluoroquinazoline (0.21 g, 0.97 mmol) was dissolved in tetrahydrofuran (1 mL) in a 50 mL single-neck flask. After 2,4-dichloro-6-fluoroquinazoline was completely dissolved, aqueous sodium hydroxide solution (1 M, 8 mL) was added and the reaction mixture was stirred at room temperature and under nitrogen protection for 12 hours. After completion of the reaction, the pH of the mixture was adjusted to 5-6 with glacial acetic acid.Subsequently, the reaction mixture was extracted with ethyl acetate (10 mL × 2). The organic phases were combined and concentrated to give the crude product. The crude product was purified by silica gel column chromatography with petroleum ether/ethyl acetate (v/v = 4/1) as eluent to yield 2-chloro-4-oxo-6-fluoroquinazoline (white solid, 0.16 g, 83% yield). The product was confirmed by mass spectrometry (ESI, positive ion mode), m/z: 199.1 [M + H]+; 1H NMR (CDCl3, 400 MHz) δ (ppm): 10.93 (s, 1H), 7.92 (dd, J = 8.0 Hz, 3.0 Hz, 1H), 7.71 (dd, J = 9.0 Hz, 4.8 Hz, 1H), 7.53 ( td, J = 8.4 Hz, 3.0 Hz, 1H).

References

[1] Journal of Medicinal Chemistry, 2007, vol. 50, # 10, p. 2297 - 2300
[2] Patent: WO2017/12502, 2017, A1. Location in patent: Page/Page column 52; 53
[3] Patent: CN105949203, 2016, A. Location in patent: Page/Page column 0179; 0189; 0190

2-CHLORO-6-FLUOROQUINAZOLIN-4(3H)-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-6-FLUOROQUINAZOLIN-4(3H)-ONE Suppliers

China 49 India 1 United Kingdom 1 United States 5 Global 56

ChemFuture PharmaTech (Jiangsu) Ltd

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Capot Chemical Co.,Ltd.

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View Lastest Price from 2-CHLORO-6-FLUOROQUINAZOLIN-4(3H)-ONE manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 2-CHLORO-6-FLUOROQUINAZOLIN-4(3H)-ONE 769158-12-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-07-07

769158-12-5, 2-CHLORO-6-FLUOROQUINAZOLIN-4(3H)-ONERelated Search:

Fluroxypyr

2-CHLORO-6-FLUOROQUINAZOLIN-4(3H)-ONE

2-chloro-6-fluoroquinazolin-

4(3H)-Quinazolinone, 2-chloro-6-fluoro-

2-Chloro-6-fluoro-4(1H)-quinazolinone

2-chloro-6-fluoroquinazolin-4-ol

2-chloro-6-fluoro-4(3H)-Quinazolinone

2-chloro-6-fluoro-3,4-dihydroquinazolin-4-one

769158-12-5