3-BROMO-5-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE
- Product Name
- 3-BROMO-5-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE
- CAS No.
- 960613-96-1
- Chemical Name
- 3-BROMO-5-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE
- Synonyms
- 3-BROMO-5-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE;Pyrazolo[1,5-a]pyrimidine, 3-bromo-5-chloro-;3-BROMO-5-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE ISO 9001：2015 REACH
- CBNumber
- CB22460260
- Molecular Formula
- C6H3BrClN3
- Formula Weight
- 232.47
- MOL File
- 960613-96-1.mol
3-BROMO-5-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE Property
- Density
- 2.03±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.51±0.40(Predicted)
- Appearance
- Light yellow to brown Solid
- InChI
- InChI=1S/C6H3BrClN3/c7-4-3-9-11-2-1-5(8)10-6(4)11/h1-3H
- InChIKey
- IYSBSUPWYUVHKG-UHFFFAOYSA-N
- SMILES
- C12=C(Br)C=NN1C=CC(Cl)=N2
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933599590
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B683445
- Product name
- 3-Bromo-5-chloropyrazolo[1,5-A]pyrimidine
- Packaging
- 250mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 3H32-D-85
- Product name
- 3-Bromo-5-chloropyrazolo[1,5-a]pyrimidine
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- W9801
- Product name
- 3-Bromo-5-chloropyrazolo[1,5-a]pyrimidine
- Packaging
- 250mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FB04099
- Product name
- 3-Bromo-5-chloropyrazolo[1,5-a]pyrimidine
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FB04099
- Product name
- 3-Bromo-5-chloropyrazolo[1,5-a]pyrimidine
- Packaging
- 2g
- Price
- $300
- Updated
- 2021/12/16
3-BROMO-5-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE Chemical Properties,Usage,Production
Uses
3-Bromo-5-chloropyrazolo[1,5-A]pyrimidine shows much similarity to 4H-Pyrazolo[1,5-a]pyrimidin-7-one which is a moiety present in a variety of chemical anti-inflammatory and antischistosomal drugs.
Synthesis
29274-24-6
960613-96-1
The general procedure for the synthesis of 3-bromo-5-chloropyrazolo[1,5-A]pyrimidines from 5-chloropyrazolo[1,5-a]pyrimidines is as follows: intermediate Example A Preparation of 3-bromo-5-chloro-pyrazolo[1,5-a]pyrimidine [Intermediate A]. To a stirred mixture of 5-chloro-pyrazolo[1,5-a]pyrimidine solution (46.4 g, 0.3 mol) in glacial acetic acid (700 mL), bromine (42 mL, 0.81 mol) was added dropwise at room temperature. After the dropwise addition was completed, the reaction mixture was continued to be stirred for 1 hour. The precipitate was collected by filtration, washed sequentially with glacial acetic acid and ether, and then dried. The filtrate was retained. The residue was suspended in water (500 mL) and the mixture was neutralized to neutral with concentrated ammonia. The crude product was filtered, washed sequentially with water, isopropanol and hexane and dried to give 3-bromo-5-chloro-pyrazolo[1,5-a]pyrimidine [Intermediate A] (34.6 g, 49% yield). The retained filtrate was diluted with ice water and neutralized with concentrated ammonia, and the resulting crude product was filtered, washed sequentially with isopropanol and hexane, and dried to give additional 3-bromo-5-chloro-pyrazolo[1,5-a]pyrimidine [Intermediate A] (23.6 g, 33% yield). The product was characterized by 1H-NMR (400 MHz, d6-DMSO): δ= 9.18 (2H, d), 8.41 (1H, s), 7.19 (2H, d) ppm.
References
[1] Patent: WO2007/147647, 2007, A1. Location in patent: Page/Page column 60
[2] Patent: WO2011/29027, 2011, A1. Location in patent: Page/Page column 43
[3] Patent: WO2013/134228, 2013, A1. Location in patent: Page/Page column 25
[4] Patent: WO2015/142714, 2015, A1. Location in patent: Page/Page column 12
[5] Patent: EP2960234, 2015, A1. Location in patent: Paragraph 0554
3-BROMO-5-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-BROMO-5-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE manufacturers
- Product
- 3-BROMO-5-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE 960613-96-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-01
- Product
- 3-BROMO-5-CHLOROPYRAZOLO[1,5-A]PYRIMIDINE 960613-96-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-03