ChemicalBook > CAS DataBase List > 6-Methoxynicotinamide

6-Methoxynicotinamide

Product Name
6-Methoxynicotinamide
CAS No.
7150-23-4
Chemical Name
6-Methoxynicotinamide
Synonyms
JBSNF-000088;BUTTPARK 182\12-94;6-Methoxynicotinamide;Benzopyrene Impurity 5;JBSNF-000088 (JBSNF000088;JBSNF-000088, 10 mM in DMSO;6-methoxy-3-pyridinecarboxamide;6-METHOXYPYRIDINE-3-CARBOXAMIDE;3-PYRIDINECARBOXAMIDE, 6-METHOXY-;Inhibitor,JBSNF 000088,inhibit,6-Methoxynicotinamide,JBSNF-000088
CBNumber
CB22463564
Molecular Formula
C7H8N2O2
Formula Weight
152.15
MOL File
7150-23-4.mol
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6-Methoxynicotinamide Property

Melting point:
178-180°C
Boiling point:
301.6±22.0 °C(Predicted)
Density 
1.213±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
15.17±0.50(Predicted)
color 
Off-White to Pale Beige
InChI
InChI=1S/C7H8N2O2/c1-11-6-3-2-5(4-9-6)7(8)10/h2-4H,1H3,(H2,8,10)
InChIKey
KXDSMFBEVSJYRF-UHFFFAOYSA-N
SMILES
C1=NC(OC)=CC=C1C(N)=O
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML3431
Product name
JBSNF-000088
Purity
≥98% (HPLC)
Packaging
10 mg
Price
$63.27
Updated
2025/07/31
Sigma-Aldrich
Product number
SML3431
Product name
JBSNF-000088
Purity
≥98% (HPLC)
Packaging
50 mg
Price
$268
Updated
2025/07/31
Cayman Chemical
Product number
29920
Product name
JBSNF-000088
Packaging
250mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
29920
Product name
JBSNF-000088
Packaging
500mg
Price
$96
Updated
2024/03/01
Cayman Chemical
Product number
29920
Product name
JBSNF-000088
Packaging
1g
Price
$180
Updated
2024/03/01
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6-Methoxynicotinamide Chemical Properties,Usage,Production

Description

JBSNF-000088 is a cell penetrant, potent and selective inhibitor of Nicotinamide N-methyltransferase (NNMT) that reduces 1-methyl-nicotinamide (MNA) and improved glucose control in mice models of metabolic disease. JBSNF-000088 potently inhibits growth of PFA ependymoma cells.

Uses

JBSNF-000088 is a cell penetrant, potent and selective inhibitor of Nicotinamide N-methyltransferase (NNMT) that reduces 1-methyl-nicotinamide (MNA) and improved glucose control in mice models of metabolic disease. JBSNF-000088 potently inhibits growth of PFA ependymoma cells.

Uses

6-Methoxynicotinamide (50 mg/kg) reduces visceral white adipose tissue (WAT) MNA levels, body weight, fed blood glucose levels, and plasma and liver triglyceride levels, and improves oral glucose tolerance in a mouse model of diet-induced obesity (DIO).

Biological Activity

JBSNF-000088 (6-Methoxynicotinamide) is a nicotinamide (NA) analog, a potent inhibitor of Nicotinamide N-methyltransferase (NNMT), against human NNMT (hNNMT), monkey NNMT (mkNNMT) and mouse NNMT (mNNMT) ) with IC50 values of 1.8 μM, 2.8 μM and 5.0 μM.

in vitro

JBSNF-000088 (6-Methoxynicotinamide) has IC 50 values are 1.6 and 6.3 μM for U2OS or differentiated 3T3L1 cells.

target

Target Value
hNNMT
(Cell-free assay) 		1.8 μM
mkNNM
(Cell-free assay) 		2.8 μM
mNNMT
(Cell-free assay) 		5.0 μM

6-Methoxynicotinamide Preparation Products And Raw materials

Raw materials

Preparation Products

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6-Methoxynicotinamide Suppliers

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View Lastest Price from 6-Methoxynicotinamide manufacturers

Zibo Hangyu Biotechnology Development Co., Ltd
Product
JBSNF-000088 7150-23-4
Price
US $1.00/G
Min. Order
1G
Purity
99.86%
Supply Ability
1kg
Release date
2025-12-06
Xi an Biohorlden Industry Trade Co Ltd
Product
JBSNF-000088 7150-23-4
Price
US $0.00-0.00/g
Min. Order
10g
Purity
99%
Supply Ability
25 kg
Release date
2025-04-22
Jinan Jianfeng Chemical Co., Ltd
Product
6-Methoxynicotinamide 7150-23-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
99%min
Supply Ability
5000kg
Release date
2024-09-05

7150-23-4, 6-MethoxynicotinamideRelated Search:

N-(4-CHLOROBENZYL)-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 5-OXO-2-(TRIFLUOROMETHYL)-N-[3-(TRIFLUOROMETHYL)PHENYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-ALLYL-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 2-METHYL-5-OXO-N-[3-(TRIFLUOROMETHYL)PHENYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-(2,2-DIETHOXYETHYL)-N'-[(6-METHOXY-3-PYRIDINYL)CARBONYL]UREA 2-PIPERIDINO-1H-CHROMENO[2,3-B][1,6]NAPHTHYRIDINE-1,11(2H)-DIONE N-ISOPROPYL-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 5-OXO-N-(3-PYRIDINYLMETHYL)-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-METHYL-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-(4-CHLOROBENZYL)-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-(TERT-BUTYL)-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 2-(DIMETHYLAMINO)-1H-CHROMENO[2,3-B][1,6]NAPHTHYRIDINE-1,11(2H)-DIONE 5-OXO-2-(TRIFLUOROMETHYL)-N-[3-(TRIFLUOROMETHYL)BENZYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 2-METHYL-10-OXO-10H-9-OXA-1-AZA-ANTHRACENE-3-CARBOXYLIC ACID ALLYLAMIDE N-BENZYL-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-(2,6-DIMETHYLPHENYL)-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 1H-CHROMENO[2,3-B][1,6]NAPHTHYRIDINE-1,11(2H)-DIONE N-(2,4-DIFLUOROPHENYL)-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE

  • 6-Methoxynicotinamide
  • 3-PYRIDINECARBOXAMIDE, 6-METHOXY-
  • 6-METHOXYPYRIDINE-3-CARBOXAMIDE
  • BUTTPARK 182\12-94
  • JBSNF-000088
  • JBSNF-000088 (JBSNF000088
  • 6-methoxy-3-pyridinecarboxamide
  • Inhibitor,JBSNF 000088,inhibit,6-Methoxynicotinamide,JBSNF-000088
  • Benzopyrene Impurity 5
  • JBSNF-000088, 10 mM in DMSO
  • 7150-23-4