6-Methoxynicotinamide
- Product Name
- 6-Methoxynicotinamide
- CAS No.
- 7150-23-4
- Chemical Name
- 6-Methoxynicotinamide
- Synonyms
- JBSNF-000088;BUTTPARK 182\12-94;6-Methoxynicotinamide;Benzopyrene Impurity 5;JBSNF-000088 (JBSNF000088;6-methoxy-3-pyridinecarboxamide;6-METHOXYPYRIDINE-3-CARBOXAMIDE;3-PYRIDINECARBOXAMIDE, 6-METHOXY-;Inhibitor,JBSNF 000088,inhibit,6-Methoxynicotinamide,JBSNF-000088
- CBNumber
- CB22463564
- Molecular Formula
- C7H8N2O2
- Formula Weight
- 152.15
- MOL File
- 7150-23-4.mol
6-Methoxynicotinamide Property
- Melting point:
- 178-180°C
- Boiling point:
- 301.6±22.0 °C(Predicted)
- Density
- 1.213±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 15.17±0.50(Predicted)
- color
- Off-White to Pale Beige
- InChI
- InChI=1S/C7H8N2O2/c1-11-6-3-2-5(4-9-6)7(8)10/h2-4H,1H3,(H2,8,10)
- InChIKey
- KXDSMFBEVSJYRF-UHFFFAOYSA-N
- SMILES
- C1=NC(OC)=CC=C1C(N)=O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 29920
- Product name
- JBSNF-000088
- Packaging
- 250mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 29920
- Product name
- JBSNF-000088
- Packaging
- 500mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- 29920
- Product name
- JBSNF-000088
- Packaging
- 1g
- Price
- $180
- Updated
- 2024/03/01
- Product number
- V7449
- Product name
- 6-Methoxynicotinamide
- Packaging
- 1g
- Price
- $161
- Updated
- 2021/12/16
- Product number
- J54609
- Product name
- 6-Methoxynicotinamide
- Packaging
- 5g
- Price
- $360
- Updated
- 2021/12/16
6-Methoxynicotinamide Chemical Properties,Usage,Production
Description
JBSNF-000088 is a cell penetrant, potent and selective inhibitor of Nicotinamide N-methyltransferase (NNMT) that reduces 1-methyl-nicotinamide (MNA) and improved glucose control in mice models of metabolic disease. JBSNF-000088 potently inhibits growth of PFA ependymoma cells.
Uses
JBSNF-000088 is a cell penetrant, potent and selective inhibitor of Nicotinamide N-methyltransferase (NNMT) that reduces 1-methyl-nicotinamide (MNA) and improved glucose control in mice models of metabolic disease. JBSNF-000088 potently inhibits growth of PFA ependymoma cells.
Biological Activity
JBSNF-000088 (6-Methoxynicotinamide) is a nicotinamide (NA) analog, a potent inhibitor of Nicotinamide N-methyltransferase (NNMT), against human NNMT (hNNMT), monkey NNMT (mkNNMT) and mouse NNMT (mNNMT) ) with IC50 values of 1.8 μM, 2.8 μM and 5.0 μM.
in vitro
JBSNF-000088 (6-Methoxynicotinamide) has IC 50 values are 1.6 and 6.3 μM for U2OS or differentiated 3T3L1 cells.
target
| Target | Value |
|
hNNMT (Cell-free assay) |
1.8 μM |
|
mkNNM (Cell-free assay) |
2.8 μM |
|
mNNMT (Cell-free assay) |
5.0 μM |
6-Methoxynicotinamide Preparation Products And Raw materials
Raw materials
Preparation Products
6-Methoxynicotinamide Suppliers
View Lastest Price from 6-Methoxynicotinamide manufacturers
- Product
- 6-Methoxynicotinamide 7150-23-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 20kg
- Purity
- 99%
- Supply Ability
- 200000
- Release date
- 2023-08-21
- Product
- JBSNF-000088 7150-23-4
- Price
- US $110.00-90.00/kilogram
- Min. Order
- 1kilogram
- Purity
- 99%
- Supply Ability
- 10 tons/per week
- Release date
- 2023-12-18
- Product
- JBSNF-000088 7150-23-4
- Price
- US $110.00-90.00/kilogram
- Min. Order
- 1kilogram
- Purity
- 99%
- Supply Ability
- 10 tons/per week
- Release date
- 2023-12-22