(R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE
- Product Name
- (R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE
- CAS No.
- 874964-22-4
- Chemical Name
- (R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE
- Synonyms
- (R)-Methyl pyrrolidine-3-...;(R)-methyl pyrrolidine-3-carboxylate methyl(S)-pyrrolidine-3-carboxylatehydrochloride;1H-Benzimidazole-1-acetonitrile,2,3-dihydro-7-oxo-;(R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE;Methyl (3R)-3-pyrrolidinecarboxylate hydrochloride;methyl (3R)-pyrrolidine-3-carboxylate hydrochloride;R-3-Pyrrolidinecarboxylic acid Methyl ester hydrochloride;(3R)-3-Pyrrolidinecarboxylic acid methyl ester hydrochloride;3-Pyrrolidinecarboxylic acid, Methyl ester, hydrochloride, (3R)-
- CBNumber
- CB22465568
- Molecular Formula
- C6H12ClNO2
- Formula Weight
- 165.62
- MOL File
- 874964-22-4.mol
(R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Off-white to light yellow Solid
- optical activity
- Consistent with structure
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M324825
- Product name
- (R)-MethylPyrrolidine-3-carboxylateHydrochloride
- Packaging
- 500mg
- Price
- $210
- Updated
- 2021/12/16
- Product number
- CCH0033044
- Product name
- (R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $218.4
- Updated
- 2021/12/16
- Product number
- AS17032-B
- Product name
- (R)-Methyl pyrrolidine-3-carboxylate HCl
- Purity
- 97% ee
- Packaging
- 1g
- Price
- $242
- Updated
- 2021/12/16
- Product number
- 4H57-5-R2
- Product name
- Methyl (3R)-pyrrolidine-3-carboxylate hydrochloride
- Packaging
- 1g
- Price
- $249
- Updated
- 2021/12/16
- Product number
- CS-B0685
- Product name
- (R)-methylpyrrolidine-3-carboxylatehydrochloride
- Purity
- ≥97.0%
- Packaging
- 5g
- Price
- $445
- Updated
- 2021/12/16
(R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
(R)-Methyl Pyrrolidine-3-carboxylate Hydrochloride acts as a reagent for the synthesis of kinase inhibitor (ERK1/2).
Synthesis
67-56-1
72925-16-7
874964-22-4
To a stirred solution of (3R)-1-{[(1,1-dimethylethyl)oxy]carbonyl}-3-pyrrolidinecarboxylic acid (1.03 g, 4.8 mmol) in methanol (25 mL) was added thionyl chloride (1 mL, 13.7 mmol) dropwise at room temperature under the protection of nitrogen atmosphere. The reaction mixture was heated to reflux for 2 hours and then cooled to room temperature. The reaction mixture was concentrated and the crude product was dissolved in dichloromethane. The solution was further concentrated to give 0.792 g (100% yield) of methyl (3R)-3-pyrrolidine carboxylic acid hydrochloride as an off-white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 9.93 (m, 2H), 3.74 (s, 3H), 3.58 (br s, 2H), 3.42 (br s, 2H), 3.26 (m, 1H), 2.36-2.25 (m, 2H).
References
[1] Patent: WO2009/5998, 2009, A1. Location in patent: Page/Page column 244
(R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE manufacturers
- Product
- (R)-METHYL PYRROLIDINE-3-CARBOXYLATE HYDROCHLORIDE 874964-22-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09