3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE
- Product Name
- 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE
- CAS No.
- 870063-60-8
- Chemical Name
- 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE
- Synonyms
- 3-fluoro-4-Pyridinemethanol;3-Fluoro-4-(hydroxyMethyl...;4-PyridineMethanol, 3-fluoro-;(3-FLUOROPYRIDIN-4-YL)METHANOL;3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE;(3-Fluoro-Pyridin-4-Yl)-Methanol(WX640299)
- CBNumber
- CB22465720
- Molecular Formula
- C6H6FNO
- Formula Weight
- 127.12
- MOL File
- 870063-60-8.mol
3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE Property
- Melting point:
- 83-84 °C
- Boiling point:
- 221.0±25.0 °C(Predicted)
- Density
- 1.262±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- pka
- 12.71±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- MNO000191
- Product name
- (3-Fluoropyridin-4-yl)methanol
- Packaging
- 1g
- Price
- $179
- Updated
- 2025/07/31
- Product number
- B435033
- Product name
- (3-Fluoropyridin-4-yl)methanol
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4H01-3-60
- Product name
- (3-Fluoropyridin-4-yl)methanol
- Packaging
- 5G
- Price
- $87
- Updated
- 2021/12/16
- Product number
- 064632
- Product name
- (3-Fluoropyridin-4-yl)methanol
- Purity
- 95%
- Packaging
- 5g
- Price
- $89
- Updated
- 2021/12/16
- Product number
- J96816
- Product name
- (3-Fluoropyridin-4-yl)methanol
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE Chemical Properties,Usage,Production
Synthesis
372-47-4
68-12-2
870063-60-8
Step 1. Synthesis of (3-fluoropyridin-4-yl)methanol 3-Fluoropyridine (600 g, 6.18 mol) was dissolved in anhydrous THF (6 L) under nitrogen protection, mechanically stirred and cooled to -65 °C. A THF solution of lithium diisopropylamine (3.4 L, 6.5 mol) was slowly added over a period of 2 h. The reaction temperature was kept below -60 °C and stirring was continued for 1 h at this temperature. Subsequently, pure DMF (804 mL, 10.4 mol) was added dropwise over 1 h, the temperature was maintained below -60 °C and the reaction was monitored by TLC until the 3-fluoropyridine was completely consumed. Upon completion of the reaction, the mixture was slowly warmed to -10 °C and water (1.1 Kg, 62 mol) was added. Sodium borohydride (234 g, 6.18 mol) was added in batches at 0 °C and stirred for a few minutes. Next, 6 M HCl (5.6 L) was added slowly over 1 h. The quenching temperature was controlled to be between 0-25°C. The reaction mixture was heated to 40°C and stirred overnight. After cooling to 0-15 °C, the pH was adjusted to 12 by slow addition of 6 M NaOH. the aqueous layer was extracted with isopropyl acetate (500 mL x 1,1L x 3). The organic layers were combined, washed with brine, dried over Na2SO4 and concentrated under reduced pressure. Heptane-isopropyl acetate (1.2L, v/v=5/1) was added to the crude product and the product was stirred at 0°C for 30 min to crystallize. Filtered, the filter cake was washed with cooled heptane (250 mL x 1) and dried under vacuum to give the light yellow solid title compound (688 g, 88% yield). 1H NMR (400 MHz, CDCl3) δ 8.42 (d, J=4.8 Hz, 1H), 8.40 (d, J=1.6 Hz, 1H), 7.49 (t, J=4.8 Hz, 1H), 4.85 (s, 2H), 2.35 (br s, 1H).
References
[1] Patent: WO2016/49048, 2016, A1. Location in patent: Paragraph 0122
[2] Patent: WO2016/100349, 2016, A2. Location in patent: Paragraph 0171
3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE manufacturers
- Product
- 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE 870063-60-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%
- Supply Ability
- 500KG
- Release date
- 2018-08-19