ChemicalBook > CAS DataBase List > 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE

3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE

Product Name
3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE
CAS No.
870063-60-8
Chemical Name
3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE
Synonyms
3-fluoro-4-Pyridinemethanol;3-Fluoro-4-(hydroxyMethyl...;4-PyridineMethanol, 3-fluoro-;(3-FLUOROPYRIDIN-4-YL)METHANOL;3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE;(3-Fluoro-Pyridin-4-Yl)-Methanol(WX640299)
CBNumber
CB22465720
Molecular Formula
C6H6FNO
Formula Weight
127.12
MOL File
870063-60-8.mol
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3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE Property

Melting point:
83-84 °C
Boiling point:
221.0±25.0 °C(Predicted)
Density 
1.262±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
form 
solid
pka
12.71±0.10(Predicted)
Appearance
White to off-white Solid
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Safety

HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
MNO000191
Product name
(3-Fluoropyridin-4-yl)methanol
Packaging
1g
Price
$179
Updated
2025/07/31
TRC
Product number
B435033
Product name
(3-Fluoropyridin-4-yl)methanol
Packaging
100mg
Price
$75
Updated
2021/12/16
Apolloscientific
Product number
PC520662
Product name
(3-Fluoropyridin-4-yl)methanol
Purity
99%
Packaging
1g
Price
$15
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
Y15323
Product name
(3-Fluoropyridin-4-yl)methanol
Purity
98%
Packaging
1g
Price
$17
Updated
2021/12/16
SynQuest Laboratories
Product number
4H01-3-60
Product name
(3-Fluoropyridin-4-yl)methanol
Packaging
1g
Price
$29
Updated
2021/12/16
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3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE Chemical Properties,Usage,Production

Synthesis

372-47-4

68-12-2

870063-60-8

Step 1. Synthesis of (3-fluoropyridin-4-yl)methanol 3-Fluoropyridine (600 g, 6.18 mol) was dissolved in anhydrous THF (6 L) under nitrogen protection, mechanically stirred and cooled to -65 °C. A THF solution of lithium diisopropylamine (3.4 L, 6.5 mol) was slowly added over a period of 2 h. The reaction temperature was kept below -60 °C and stirring was continued for 1 h at this temperature. Subsequently, pure DMF (804 mL, 10.4 mol) was added dropwise over 1 h, the temperature was maintained below -60 °C and the reaction was monitored by TLC until the 3-fluoropyridine was completely consumed. Upon completion of the reaction, the mixture was slowly warmed to -10 °C and water (1.1 Kg, 62 mol) was added. Sodium borohydride (234 g, 6.18 mol) was added in batches at 0 °C and stirred for a few minutes. Next, 6 M HCl (5.6 L) was added slowly over 1 h. The quenching temperature was controlled to be between 0-25°C. The reaction mixture was heated to 40°C and stirred overnight. After cooling to 0-15 °C, the pH was adjusted to 12 by slow addition of 6 M NaOH. the aqueous layer was extracted with isopropyl acetate (500 mL x 1,1L x 3). The organic layers were combined, washed with brine, dried over Na2SO4 and concentrated under reduced pressure. Heptane-isopropyl acetate (1.2L, v/v=5/1) was added to the crude product and the product was stirred at 0°C for 30 min to crystallize. Filtered, the filter cake was washed with cooled heptane (250 mL x 1) and dried under vacuum to give the light yellow solid title compound (688 g, 88% yield). 1H NMR (400 MHz, CDCl3) δ 8.42 (d, J=4.8 Hz, 1H), 8.40 (d, J=1.6 Hz, 1H), 7.49 (t, J=4.8 Hz, 1H), 4.85 (s, 2H), 2.35 (br s, 1H).

References

[1] Patent: WO2016/49048, 2016, A1. Location in patent: Paragraph 0122
[2] Patent: WO2016/100349, 2016, A2. Location in patent: Paragraph 0171

3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE Suppliers

China 81 Germany 1 India 1 United States 9 Global 92
Alchem Pharmtech,Inc.
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Synthonix Inc
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Frontier Scientific, Inc.
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Matrix Scientific
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View Lastest Price from 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE manufacturers

Career Henan Chemical Co
Product
3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE 870063-60-8
Price
US $1.00/KG
Min. Order
1KG
Purity
95%
Supply Ability
500KG
Release date
2018-08-19

870063-60-8, 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINERelated Search:

Benzotrifluoride

  • (3-FLUOROPYRIDIN-4-YL)METHANOL
  • 3-FLUORO-4-(HYDROXYMETHYL)PYRIDINE
  • 3-Fluoro-4-(hydroxyMethyl...
  • 4-PyridineMethanol, 3-fluoro-
  • 3-fluoro-4-Pyridinemethanol
  • (3-Fluoro-Pyridin-4-Yl)-Methanol(WX640299)
  • 870063-60-8