1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)-
- Product Name
- 1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)-
- CAS No.
- 915226-43-6
- Chemical Name
- 1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)-
- Synonyms
- (R)-1-Boc-3-carbamoylpiperidine;(R)-1-Boc-3-piperidinecarboxaMide;(R)-1-Boc-3-(aMinocarbonyl)-piperidine;tert-Butyl (R)-3-carbamoylpiperidine-1-carboxylate;(R)-tert-Butyl 3-carbaMoylpiperidine-1-carboxylate;tert-butyl (3R)-3-carbamoylpiperidine-1-carboxylate;1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)-
- CBNumber
- CB22468655
- Molecular Formula
- C11H20N2O3
- Formula Weight
- 228.29
- MOL File
- 915226-43-6.mol
1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)- Property
- Boiling point:
- 384.4±31.0 °C(Predicted)
- Density
- 1.123±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 16.41±0.20(Predicted)
- Appearance
- White to off-white Solid
- optical activity
- Consistent with structure
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- AS43276
- Product name
- (R)-tert-Butyl 3-carbamoylpiperidine-1-carboxylate
- Purity
- 95% ee
- Packaging
- 250mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- AS43276
- Product name
- (R)-tert-Butyl 3-carbamoylpiperidine-1-carboxylate
- Purity
- 95% ee
- Packaging
- 1g
- Price
- $122
- Updated
- 2021/12/16
- Product number
- 5386AC
- Product name
- (R)-tert-Butyl3-carbamoylpiperidine-1-carboxylate
- Packaging
- 1g
- Price
- $154
- Updated
- 2021/12/16
- Product number
- AS43276
- Product name
- (R)-tert-Butyl 3-carbamoylpiperidine-1-carboxylate
- Purity
- 95% ee
- Packaging
- 5G
- Price
- $342
- Updated
- 2021/12/16
- Product number
- CCH0033088
- Product name
- (R)-TERT-BUTYL-3-CARBAMOYLPIPERIDINE-1-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $342.3
- Updated
- 2021/12/16
1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)- Chemical Properties,Usage,Production
Synthesis
4138-26-5
24424-99-5
915226-43-6
The general procedure for the synthesis of tert-butyl (R)-3-carbamoylpiperidine-1-carboxylate from 3-piperidinecarboxamide and di-tert-butyl dicarbonate was as follows: to the reaction mixture obtained in Example 4 was added tetrahydrofuran (THF, 40 mL), followed by the addition of di-tert-butyl dicarbonate (37.2 g, 2.3 eq.). The pH of the reaction mixture was adjusted to 10.0 using sodium hydroxide (NaOH). the reaction mixture was stirred at room temperature for 1 hr, after which the precipitated crystals were collected by filtration to afford (R)-1 -(tert-butoxycarbonyl)piperidinamide as white crystals (15.6 g, yield: 93%). The crystals were analyzed using the method described in Example 3; the results showed an optical purity of 99.8% ee. 1H NMR (400 MHz, CDCl3) data were as follows: δ 5.36 (brs, 2H), 3.94-3.08 (m, 5H), 1.96-1.36 (m, 13H).
References
[1] Patent: US2010/105917, 2010, A1. Location in patent: Page/Page column 16
1-PIPERIDINECARBOXYLIC ACID, 3-(AMINOCARBONYL)-, 1,1-DIMETHYLETHYL ESTER, (3R)- Preparation Products And Raw materials
Raw materials
Preparation Products
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