ChemicalBook > CAS DataBase List > 5-Chloropyrazine-2-carboxylic acid hydrazide

5-Chloropyrazine-2-carboxylic acid hydrazide

Product Name: 5-Chloropyrazine-2-carboxylic acid hydrazide
CAS No.: 848952-83-0
Chemical Name: 5-Chloropyrazine-2-carboxylic acid hydrazide
Synonyms: 5-chloropyrazine-2-carbohydrazide;5-Chloropyrazine-2-carboxylic acid hydrazide;5-chloropyrazine-2-carboxylic acid hydyazide;2-Pyrazinecarboxylic acid, 5-chloro-, hydrazide
CBNumber: CB22470157
Molecular Formula: C5H5ClN4O
Formula Weight: 172.57
MOL File: 848952-83-0.mol

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5-Chloropyrazine-2-carboxylic acid hydrazide Property

Density: 1.496±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 9.51±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C381238
Product name: 5-Chloropyrazine-2-carboxylicacidhydrazide
Packaging: 25mg
Price: $45
Updated: 2021/12/16

TRC

Product number: C381238
Product name: 5-Chloropyrazine-2-carboxylicacidhydrazide
Packaging: 50mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC144192
Product name: 5-Chloropyrazine-2-carboxylic acid hydrazide
Packaging: 100mg
Price: $56
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC144192
Product name: 5-Chloropyrazine-2-carboxylic acid hydrazide
Packaging: 250mg
Price: $112.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC144192
Product name: 5-Chloropyrazine-2-carboxylic acid hydrazide
Packaging: 500mg
Price: $195
Updated: 2021/12/16

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5-Chloropyrazine-2-carboxylic acid hydrazide Chemical Properties,Usage,Production

Synthesis

33332-25-1

848952-83-0

General procedure for the synthesis of 5-chloropyrazine-2-carboxylic acid hydrazide from methyl 5-chloropyrazine-2-carboxylate: 1. Preparation of 5-chloropyrazine-2-carboxylic acid hydrazide: 5-chloropyrazine-2-carboxylic acid methyl ester (10.02 g, 58.25 mmol) and hydrazine monohydrate (12.5 mL, 250 mmol) were dissolved in methanol (400 mL). The reaction mixture was heated to reflux for 48 hours. Upon completion of the reaction, the mixture was filtered, the precipitate was collected and dried under vacuum to afford the target product 5-chloropyrazine-2-carboxylic acid hydrazine in a yield of 5.01 g (50% yield). Product characterization data: 1H NMR (CDCl3, 400 MHz) δ: 4.09 (d, 2H), 8.52 (s, 1H), 8.66 (bs, 1H), 9.14 (s, 1H). Elemental analysis: C5H5ClN4O Theoretical values: C 34.80; H 2.92; N 32.47; Measured values: C 34.89; H 2.91; N 32.32. Mass spectral data: MS APCI+ m/z 173 [MH]+.

References

[1] Journal of Medicinal Chemistry, 2015, vol. 58, # 13, p. 5344 - 5354
[2] Patent: WO2007/17752, 2007, A1. Location in patent: Page/Page column 33
[3] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 10, p. 2634 - 2636
[4] Patent: WO2006/100557, 2006, A1. Location in patent: Page/Page column 24

5-Chloropyrazine-2-carboxylic acid hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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848952-83-0