Pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione

Product Name: Pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione
CAS No.: 57489-70-0
Chemical Name: Pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione
Synonyms: Pyrazolo[1,5-a]pyrimidine-5,7-ol;pyrazolo[1,5-a]pyrimidine-5,7-diol;7-Hydroxy-4H-pyrazolo[1,5-a]pyrimidin-5-one;5-Hydroxy-4H-pyrazolo[1,5-a]pyrimidin-7-one;7-Hydroxypyrazolo[1,5-a]pyrimidin-5(4H)-one;7-hydroxy-1h-pyrazolo[1,5-a]pyrimidin-5-one;Pyrazolo[1,5-a]pyrimidin-5(4H)-one, 7-hydroxy-
CBNumber: CB22470218
Molecular Formula: C6H5N3O2
Formula Weight: 151.12
MOL File: 57489-70-0.mol

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Pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione Property

Melting point:: 239-240 °C (decomp)
Boiling point:: 290.6±40.0 °C(Predicted)
Density: 1.74±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 4.50±1.00(Predicted)
Appearance: Off-white to light yellow Solid

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P846525
Product name: Pyrazolo[1,5-a]pyrimidine-5,7-diol
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Apolloscientific

Product number: OR927008
Product name: Pyrazolo[1,5-a]pyrimidine-5,7-diol
Purity: 96%
Packaging: 1g
Price: $130
Updated: 2021/12/16

Apolloscientific

Product number: OR927008
Product name: Pyrazolo[1,5-a]pyrimidine-5,7-diol
Purity: 96%
Packaging: 5g
Price: $310
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0313128
Product name: PYRAZOLO[1,5-A]PYRIMIDINE-5,7-DIOL
Purity: 95.00%
Packaging: 5MG
Price: $499.29
Updated: 2021/12/16

Apolloscientific

Product number: OR927008
Product name: Pyrazolo[1,5-a]pyrimidine-5,7-diol
Purity: 96%
Packaging: 10g
Price: $555
Updated: 2021/12/16

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Pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione Chemical Properties,Usage,Production

Synthesis

1820-80-0

105-53-3

57489-70-0

Step A - Synthesis of pyrazolo[1,5-a]pyrimidine-5,7-diol (Int-9a): to 1H-pyrazol-3-amine (12.3 g, 148.0 mmol) in 50 mL of deionized water was added diethyl malonate (25.0 mL, 164.7 mmol), followed by the addition of an ethanolic solution of 21 wt% NaOEt (110 mL. 294.6 mmol) and additional ethanol (50 mL). The reaction mixture was heated at 80 °C for 16 h under argon protection. After completion of the reaction, it was cooled to room temperature. The reaction mixture was concentrated to near dryness under reduced pressure and 500 mL of water was added. Dissolution of the solid was promoted by vigorous stirring and the pH was subsequently adjusted to ~2 with hydrochloric acid, at which point a precipitate was generated. The precipitate was collected by vacuum filtration and dried to give pyrazolo[1,5-a]pyrimidine-5,7-diol (Int-9a) as a brown solid (17.13 g, 113.4 mmol, 77% yield).

References

[1] Patent: WO2011/2887, 2011, A1. Location in patent: Page/Page column 86
[2] Patent: WO2012/27234, 2012, A1. Location in patent: Page/Page column 39; 40
[3] Patent: US2011/294781, 2011, A1. Location in patent: Page/Page column 20
[4] Patent: WO2012/27240, 2012, A1. Location in patent: Page/Page column 47
[5] Patent: WO2012/47569, 2012, A1. Location in patent: Page/Page column 41

Pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione Preparation Products And Raw materials

Raw materials

Preparation Products

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Pyrazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione Suppliers

China 46 India 1 United States 3 Global 50

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57489-70-0