tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate
- Product Name
- tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate
- CAS No.
- 1207175-73-2
- Chemical Name
- tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate
- Synonyms
- 2-(Boc-amino)-5-bromo-3-hydroxypyridine;tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate;tert-butyl N-(5-bromo-3-hydroxy-2-pyridyl)carbamate;ert-butylN-(5-bromo-3-hydroxypyridin-2-yl)carbamate;Tert butyl 5-bromo-3-hydroxypyridin-2-ylaminoformate;tert-butyl N-(5-bromo-3-hydroxypyridin-2-yl)carbamate;Carbamic acid, N-(5-bromo-3-hydroxy-2-pyridinyl)-, 1,1-dimethylethyl ester
- CBNumber
- CB22470379
- Molecular Formula
- C10H13BrN2O3
- Formula Weight
- 289.13
- MOL File
- 1207175-73-2.mol
tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate Property
- Boiling point:
- 363.8±42.0 °C(Predicted)
- Density
- 1.552
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 8.02±0.10(Predicted)
- Appearance
- Yellow to brown Solid
- InChI
- InChI=1S/C10H13BrN2O3/c1-10(2,3)16-9(15)13-8-7(14)4-6(11)5-12-8/h4-5,14H,1-3H3,(H,12,13,15)
- InChIKey
- FKSQRZXAISFJAG-UHFFFAOYSA-N
- SMILES
- C(OC(C)(C)C)(=O)NC1=NC=C(Br)C=C1O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T135783
- Product name
- tert-Butyl(5-Bromo-3-hydroxypyridin-2-yl)carbamate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- 7359AJ
- Product name
- tert-Butyl5-bromo-3-hydroxypyridin-2-ylcarbamate
- Packaging
- 250mg
- Price
- $157
- Updated
- 2021/12/16
- Product number
- HCH0295150
- Product name
- TERT-BUTYL-5-BROMO-3-HYDROXYPYRIDIN-2-YLCARBAMATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $504.06
- Updated
- 2021/12/16
- Product number
- OR470878
- Product name
- 2-(Boc-amino)-5-bromo-3-hydroxypyridine
- Packaging
- 1g
- Price
- $1040
- Updated
- 2021/12/16
- Product number
- 4H56-9-8J
- Product name
- 2-(Boc-amino)-5-bromo-3-hydroxypyridine
- Packaging
- 1g
- Price
- $1232
- Updated
- 2021/12/16
tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate Chemical Properties,Usage,Production
Synthesis
24424-99-5
39903-01-0
1207175-73-2
Example 1 Synthesis of 5-bromo-3-hydroxy-2-tert-butoxycarbonylaminopyridine (0038): 2-amino-3-hydroxy-5-bromopyridine (10.0 g, 53.0 mmol) and triethylamine (10 mL, 71.8 mmol) were added to dichloromethane (100 mL) followed by di-tert-butyl dicarbonate (12.7 g, 58.4 mmol). The reaction mixture was stirred at room temperature for 18 hours. Water (150 mL) was added and stirring was continued for 30 minutes. The reaction mixture was filtered through diatomaceous earth to separate the organic layer. The aqueous layer was extracted with dichloromethane (150 mL). The combined organic layers were washed with saturated aqueous sodium chloride (2 x 100 mL) and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure and the residue was ground with hexane (100 mL), filtered and dried in vacuum to give 5-bromo-3-hydroxy-2-tert-butoxycarbonylaminopyridine (15.0 g, 98.0% yield) as a white solid. Product characterization data: 1H NMR (400 MHz, CDCl3) δ 7.98 (d, J = 2.0 Hz, 1H), 7.58 (d, J = 2.0 Hz, 1H), 4.67 (br s, 2H), 1.56 (s, 9H); 13C NMR (100 MHz, CDCl3) δ 150.4, 150.1, 145.3, 133.5, 131.3 133.5, 131.5, 106.5, 85.0, 27.6.
References
[1] Patent: US2015/307476, 2015, A1. Location in patent: Paragraph 0038-0039
[2] Tetrahedron Letters, 2014, vol. 55, # 9, p. 1528 - 1531
tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate Preparation Products And Raw materials
Raw materials
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View Lastest Price from tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate manufacturers
- Product
- tert-butyl 5-bromo-3-hydroxypyridin-2-ylcarbamate 1207175-73-2
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2019-12-25