3,5-Dibromo-2-pyridylamine
- Product Name
- 3,5-Dibromo-2-pyridylamine
- CAS No.
- 35486-42-1
- Chemical Name
- 3,5-Dibromo-2-pyridylamine
- Synonyms
- AKOS BB-8249;AURORA KA-520;ASISCHEM X26831;AKOS BBS-00001351;TIMTEC-BB SBB000910;2-Amino-3,5-dibromo;Xylulose Impurity 2;SALOR-INT L495980-1EA;LABOTEST-BB LT00000217;Palbociclib Impurity 90
- CBNumber
- CB3303872
- Molecular Formula
- C5H4Br2N2
- Formula Weight
- 251.91
- MOL File
- 35486-42-1.mol
3,5-Dibromo-2-pyridylamine Property
- Melting point:
- 104-105 °C (lit.)
- Boiling point:
- 253.9±35.0 °C(Predicted)
- Density
- 2.147±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 1.89±0.49(Predicted)
- Appearance
- Light yellow to yellow Solid
- BRN
- 119390
- InChI
- InChI=1S/C5H4Br2N2/c6-3-1-4(7)5(8)9-2-3/h1-2H,(H2,8,9)
- InChIKey
- WJMJWMSWJSACSN-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C(Br)C=C1Br
- CAS DataBase Reference
- 35486-42-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A1588
- Product name
- 2-Amino-3,5-dibromopyridine
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $18
- Updated
- 2025/07/31
- Product number
- A1588
- Product name
- 2-Amino-3,5-dibromopyridine
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $28
- Updated
- 2025/07/31
- Product number
- A610678
- Product name
- 2-Amino-3,5-dibromopyridine
- Packaging
- 2.5g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 415046
- Product name
- 2-Amino-3,5-dibromopyridine
- Packaging
- 500mg
- Price
- $305
- Updated
- 2021/12/16
- Product number
- 018180
- Product name
- 2-Amino-3,5-dibromopyridine
- Purity
- 98%
- Packaging
- 5g
- Price
- $10
- Updated
- 2021/12/16
3,5-Dibromo-2-pyridylamine Chemical Properties,Usage,Production
Chemical Properties
yellow to brown fine crystalline powder
General Description
The synthesis of 2-amino-3,5-dibromopyridine complexes and their analysis by single crystal X-ray diffraction has been studied.
Synthesis
504-29-0
1072-97-5
35486-42-1
General procedure for the synthesis of 2-amino-5-bromopyridine and 2-amino-3,5-dibromopyridine from 2-aminopyridine: 28.2 g (0.3 mol) of 2-aminopyridine was dissolved in 50 ml of acetic acid. The solution is cooled to below 20°C by means of an ice bath and 48 g (15.4 ml, 0.3 mol) of bromine dissolved in 30 ml of acetic acid is added slowly and dropwise over a period of 1 h under vigorous stirring. The temperature was maintained below 20°C at the beginning of the reaction. Upon addition of half of the bromine solution, the reaction temperature was raised to 50°C to promote precipitation of 2-amino-5-bromopyridine hydrobromide. At 50°C, the hydrobromide typically begins to crystallize when about three-quarters of the bromine is added. After completion of the bromine addition, stirring of the reaction mixture was continued for 1 hour, followed by dilution with 75 mL of water to dissolve the hydrobromide. The reaction solution is transferred to a 500 ml beaker and neutralized by the slow addition of 120 ml of 40% sodium hydroxide solution under stirring and cooling conditions. Filtration and drying gave a crude product of 2-amino-5-bromopyridine containing a small amount of 2-amino-3,5-dibromopyridine. The 2-amino-3,5-dibromopyridine was removed from the crude product by washing with 500 ml of hot petroleum ether in three passes. The final yield of 2-amino-5-bromopyridine was 32-34.7 g (62-67% yield) with a melting point of 134°C (literature value: 132-135°C).
Purification Methods
Steam distil it and recrystallise it from aqueous EtOH or pet ether. [Beilstein 22 H 431, 22 II 333, 22 III/IV 4041.]
References
[1] Synthetic Communications, 1986, vol. 16, # 13, p. 1641 - 1646
[2] Canadian Journal of Chemistry, 2005, vol. 83, # 2, p. 146 - 149
[3] Synthesis (Germany), 2015, vol. 47, # 20, p. 3169 - 3178
[4] Journal of Organic Chemistry, 1983, vol. 48, # 7, p. 1064 - 1069
[5] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 7, p. 2455 - 2478
3,5-Dibromo-2-pyridylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3,5-Dibromo-2-pyridylamine manufacturers
- Product
- 3,5-Dibromo-2-pyridylamine 35486-42-1
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
- Product
- 3,5-Dibromo-2-pyridylamine 35486-42-1
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-05
- Product
- 3,5-Dibromo-2-pyridylamine 35486-42-1
- Price
- US $20.00-1.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-10-24