ChemicalBook > CAS DataBase List > 3,5-Dibromo-2-pyridylamine

3,5-Dibromo-2-pyridylamine

Product Name: 3,5-Dibromo-2-pyridylamine
CAS No.: 35486-42-1
Chemical Name: 3,5-Dibromo-2-pyridylamine
Synonyms: AKOS BB-8249;AURORA KA-520;ASISCHEM X26831;AKOS BBS-00001351;TIMTEC-BB SBB000910;2-Amino-3,5-dibromo;Xylulose Impurity 2;SALOR-INT L495980-1EA;LABOTEST-BB LT00000217;Palbociclib Impurity 90
CBNumber: CB3303872
Molecular Formula: C5H4Br2N2
Formula Weight: 251.91
MOL File: 35486-42-1.mol

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3,5-Dibromo-2-pyridylamine Property

Melting point:: 104-105 °C (lit.)
Boiling point:: 253.9±35.0 °C(Predicted)
Density: 2.147±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 1.89±0.49(Predicted)
Appearance: Light yellow to yellow Solid
BRN: 119390
InChI: InChI=1S/C5H4Br2N2/c6-3-1-4(7)5(8)9-2-3/h1-2H,(H2,8,9)
InChIKey: WJMJWMSWJSACSN-UHFFFAOYSA-N
SMILES: C1(N)=NC=C(Br)C=C1Br
CAS DataBase Reference: 35486-42-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-37/39-36
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A1588
Product name: 2-Amino-3,5-dibromopyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $18
Updated: 2025/07/31

TCI Chemical

Product number: A1588
Product name: 2-Amino-3,5-dibromopyridine
Purity: >98.0%(GC)
Packaging: 25g
Price: $28
Updated: 2025/07/31

TRC

Product number: A610678
Product name: 2-Amino-3,5-dibromopyridine
Packaging: 2.5g
Price: $65
Updated: 2021/12/16

Usbiological

Product number: 415046
Product name: 2-Amino-3,5-dibromopyridine
Packaging: 500mg
Price: $305
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0018249
Product name: 2-AMINO-3,5-DIBROMO PYRIDINE
Purity: 95.00%
Packaging: 5G
Price: $774.04
Updated: 2021/12/16

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3,5-Dibromo-2-pyridylamine Chemical Properties,Usage,Production

Chemical Properties

yellow to brown fine crystalline powder

General Description

The synthesis of 2-amino-3,5-dibromopyridine complexes and their analysis by single crystal X-ray diffraction has been studied.

Synthesis

504-29-0

1072-97-5

35486-42-1

General procedure for the synthesis of 2-amino-5-bromopyridine and 2-amino-3,5-dibromopyridine from 2-aminopyridine: 28.2 g (0.3 mol) of 2-aminopyridine was dissolved in 50 ml of acetic acid. The solution is cooled to below 20°C by means of an ice bath and 48 g (15.4 ml, 0.3 mol) of bromine dissolved in 30 ml of acetic acid is added slowly and dropwise over a period of 1 h under vigorous stirring. The temperature was maintained below 20°C at the beginning of the reaction. Upon addition of half of the bromine solution, the reaction temperature was raised to 50°C to promote precipitation of 2-amino-5-bromopyridine hydrobromide. At 50°C, the hydrobromide typically begins to crystallize when about three-quarters of the bromine is added. After completion of the bromine addition, stirring of the reaction mixture was continued for 1 hour, followed by dilution with 75 mL of water to dissolve the hydrobromide. The reaction solution is transferred to a 500 ml beaker and neutralized by the slow addition of 120 ml of 40% sodium hydroxide solution under stirring and cooling conditions. Filtration and drying gave a crude product of 2-amino-5-bromopyridine containing a small amount of 2-amino-3,5-dibromopyridine. The 2-amino-3,5-dibromopyridine was removed from the crude product by washing with 500 ml of hot petroleum ether in three passes. The final yield of 2-amino-5-bromopyridine was 32-34.7 g (62-67% yield) with a melting point of 134°C (literature value: 132-135°C).

Purification Methods

Steam distil it and recrystallise it from aqueous EtOH or pet ether. [Beilstein 22 H 431, 22 II 333, 22 III/IV 4041.]

References

[1] Synthetic Communications, 1986, vol. 16, # 13, p. 1641 - 1646
[2] Canadian Journal of Chemistry, 2005, vol. 83, # 2, p. 146 - 149
[3] Synthesis (Germany), 2015, vol. 47, # 20, p. 3169 - 3178
[4] Journal of Organic Chemistry, 1983, vol. 48, # 7, p. 1064 - 1069
[5] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 7, p. 2455 - 2478

3,5-Dibromo-2-pyridylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,5-Dibromo-2-pyridylamine manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3,5-Dibromo-2-pyridylamine 35486-42-1
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-05-30

Hebei Chuanghai Biotechnology Co., Ltd

Product: 3,5-Dibromo-2-pyridylamine 35486-42-1
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-11-05

Hebei Yanxi Chemical Co., Ltd.

Product: 3,5-Dibromo-2-pyridylamine 35486-42-1
Price: US $20.00-1.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 10 tons
Release date: 2023-10-24

35486-42-1, 3,5-Dibromo-2-pyridylamineRelated Search:

2-AMINO-3,5-DIBROMO-6-METHYLPYRIDINE 2-Amino-3,5-dibromo-4-methylpyridine 3,5-DIBROMO-2-NITROPYRIDINE 3,5-Dibromopyridine 2,4-DIBROMO-3-AMINOPYRIDINE 2,6-Dibromopyridin-3-amine 4-AMINO-2,6-DIBROMOPYRIDINE 3,5-Dibromo-2-pyridylamine 2-Amino-3,5-dibromo-4,6-dimethylpyridine 2,6-DIAMINE-3,5-DIBROMOPYRIDINE 4-(3,5-DIBROMO-2-PYRIDYLAZO)-1,3-PHENYLENEDIAMINE 3,5-DIBROMO-6-CHLORO-N-METHYLPYRIDIN-2-AMINE 6-AMINO-3,5-DIBROMOPYRIDINE-2-CARBOXAMIDE AURORA KA-375 3,5-DIBROMO-2-HYDRAZINO-4-METHYLPYRIDINE 6-AMINO-3,5-DIBROMOPYRIDINE-2-CARBONITRILE 1-(3,5-dibromopyridin-2-yl)-1-methylhydrazine 3,5-DIBROMO-N-(PHENYLMETHYL)-2-PYRIDINAMINE

2-Amino-3,5-dibromo pyridine ,99%

3,5-Dibromo-2-pyridinamine

2-amino-3,5-dibormopyridine

2-Amino-3,5-dibromopyridine,97%

3,5-Dibromo-2-aminopyridine

2-Amino-3,5-dibromopyridine&nbsp

2-Amino-3,5-dibromo pyrdine

TIMTEC-BB SBB000910

SALOR-INT L495980-1EA

ASISCHEM X26831

AURORA KA-520

LABOTEST-BB LT00000217

2-Amino-3,5-dibromopyridine 97%

3,5-DIBROMOPYRIDIN-2-AMINE

AKOS BBS-00001351

AKOS BB-8249

2-AMINO-3,5-DIBROMOPYRIDINE

2-PYRIDINAMINE, 3,5-DIBROMO-

2-amino-3,5-dibromopyridinehydrate

2-Amino-3,5-dibromo

3,5-dibromo-2-pyridylamine

3,5-Dibromo-pyridin-2-ylamine

3,5-Dibrom-2-pyridylamin

2-Amino-3,5-dibromopyridine &gt

3,5-Dibromo-2-pyridylamine ISO 9001：2015 REACH

Palbociclib Impurity 90

2-Amino 5-bromopyrdiene

Xylulose Impurity 2

2-Amino-3,5-dibromopyridine, 98%

35486-42-1

C5H4N2Br2

C5H4Br2NxH2O

C5H4Br2NH2O

AMINE

Halopyridines

Bromopyridines

Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

Pyridines

Pyridines, Pyrimidines, Purines and Pteredines

Pyridine

Amino-pyridine series

Bromopyridines

Halopyridines

C5Heterocyclic Building Blocks

Halogenated Heterocycles

Heterocyclic Building Blocks

blocks

Bromides

Pyridines