3-Pyridinecarboxylic acid, 5-hydroxy-6-iodo-, ethyl ester
- Product Name
- 3-Pyridinecarboxylic acid, 5-hydroxy-6-iodo-, ethyl ester
- CAS No.
- 59288-40-3
- Chemical Name
- 3-Pyridinecarboxylic acid, 5-hydroxy-6-iodo-, ethyl ester
- Synonyms
- ethyl 5-hydroxy-6-iodonicotinate;5-Hydroxy-6-iodo-nicotinic acid ethyl ester;5-hydroxy-6-iodo-3-Pyridinecarboxylic acid ethyl ester;3-Pyridinecarboxylic acid, 5-hydroxy-6-iodo-, ethyl ester
- CBNumber
- CB22473673
- Molecular Formula
- C8H8INO3
- Formula Weight
- 293.06
- MOL File
- 59288-40-3.mol
3-Pyridinecarboxylic acid, 5-hydroxy-6-iodo-, ethyl ester Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 8821AB
- Product name
- Ethyl5-hydroxy-6-iodonicotinate
- Packaging
- 250mg
- Price
- $273
- Updated
- 2021/12/16
- Product number
- HCH0368970
- Product name
- ETHYL-5-HYDROXY-6-IODONICOTINATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.67
- Updated
- 2021/12/16
- Product number
- A191659
- Product name
- Ethyl5-hydroxy-6-iodonicotinate
- Purity
- 98%
- Packaging
- 5g
- Price
- $746
- Updated
- 2021/12/16
- Product number
- CD11098124
- Product name
- Ethyl5-hydroxy-6-iodonicotinate
- Purity
- 98%
- Packaging
- 5g
- Price
- $1337
- Updated
- 2021/12/16
- Product number
- 59288403
- Product name
- Ethyl5-hydroxy-6-iodonicotinate
- Packaging
- 5g
- Price
- $1417.5
- Updated
- 2021/12/16
3-Pyridinecarboxylic acid, 5-hydroxy-6-iodo-, ethyl ester Chemical Properties,Usage,Production
Synthesis
59288-38-9
59288-40-3
General procedure for the synthesis of ethyl 5-hydroxy-6-iodo-3-pyridinecarboxylate from ethyl 5-hydroxynicotinate: a solution of ethyl 5-hydroxynicotinate was added to water (15 L), followed by sodium carbonate (733 g, 30.7 mol) and iodine (965 g, 15.3 mol). The reaction was carried out at room temperature with stirring for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) (unfolding agent: petroleum ether/ethyl acetate = 1/1, Rf = 0.8) and after confirming the completion of the reaction, the pH was adjusted to 7 by slowly adding 1N hydrochloric acid to the reaction solution, when a solid precipitated. The solid product was collected by filtration and dried under reduced pressure to give ethyl 5-hydroxy-6-iodo-3-pyridinecarboxylate (925 g) as a yellow solid in 82.5% yield.
References
[1] Patent: CN105418620, 2016, A. Location in patent: Paragraph 0008; 0032; 0033
3-Pyridinecarboxylic acid, 5-hydroxy-6-iodo-, ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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