4-Chloro-5-pyrimidineacetic acid ethyl ester

Product Name: 4-Chloro-5-pyrimidineacetic acid ethyl ester
CAS No.: 6214-47-7
Chemical Name: 4-Chloro-5-pyrimidineacetic acid ethyl ester
Synonyms: 2,4-Dichloro-3,5-dinitroaniline;ethyl 2-(4-chloropyriMidin-5-yl)acetate;5-Pyrimidineacetic acid, 4-chloro-, ethyl ester;4-Chloro-5-pyrimidineacetic acid ethyl ester
CBNumber: CB22473895
Molecular Formula: C8H9ClN2O2
Formula Weight: 200.62
MOL File: 6214-47-7.mol

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4-Chloro-5-pyrimidineacetic acid ethyl ester Property

Boiling point:: 95-96 °C(Press: 0.04 Torr)
Density: 1.276±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -0.25±0.16(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Alichem

Product number: 6214477
Product name: Ethyl4-chloropyrimidine-5-acetate
Packaging: 250mg
Price: $211.89
Updated: 2021/12/16

Chemenu

Product number: CM123318
Product name: ethyl2-(4-chloropyrimidin-5-yl)acetate
Purity: 97%
Packaging: 1g
Price: $337
Updated: 2021/12/16

Crysdot

Product number: CD11088132
Product name: Ethyl2-(4-chloropyrimidin-5-yl)acetate
Purity: 97%
Packaging: 1g
Price: $356
Updated: 2021/12/16

Abosyn

Product number: 61-10223
Product name: Ethyl2-(4-chloropyrimidin-5-yl)acetate
Purity: 95-98%
Packaging: 1g
Price: $430
Updated: 2021/12/16

Alichem

Product number: 6214477
Product name: Ethyl4-chloropyrimidine-5-acetate
Packaging: 1g
Price: $554.95
Updated: 2021/12/16

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4-Chloro-5-pyrimidineacetic acid ethyl ester Chemical Properties,Usage,Production

Synthesis

6214-46-6

6214-47-7

Ethyl 2-(6-oxo-1,6-dihydropyrimidin-5-yl)acetate (1107) (0.868 g, 4.77 mmol) was mixed with phosphorus oxychloride (POCl3) (6 mL) under nitrogen protection and heated to reflux. The reaction was maintained for 5 min and then cooled to room temperature. The reaction mixture was slowly poured into water (300 mL) and the aqueous phase was extracted with dichloromethane (DCM) (3 x 100 mL). The organic phases were combined, washed with saturated saline (100 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the target compound 4-chloro-5-pyrimidine ethyl acetate (1108) (0.885 g, 93% yield) as a light yellow oil.1H NMR (400 MHz, CDCl3) δ 8.93 (s, 1H), 8.61 (s , 1H), 4.21 (q, J = 7.1 Hz, 2H), 3.76 (s, 2H), 1.28 (t, J = 7.1 Hz, 3H).LCMS method C: retention time 5.09 min; m/z 201.0, 203.1 [M+H]+.

References

[1] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 130; 132
[2] Patent: WO2014/27199, 2014, A1. Location in patent: Page/Page column 134

4-Chloro-5-pyrimidineacetic acid ethyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Chloro-5-pyrimidineacetic acid ethyl ester manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Chloro-5-pyrimidineacetic acid ethyl ester 6214-47-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000tons
Release date: 2025-08-22

Career Henan Chemical Co

Product: 4-Chloro-5-pyrimidineacetic acid ethyl ester 6214-47-7
Price: US $6.68/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-10

6214-47-7, 4-Chloro-5-pyrimidineacetic acid ethyl esterRelated Search:

Ethyl 2-(4-chloropyrimidin-5-yl)acetate

4-Chloro-5-pyrimidineacetic acid ethyl ester

ethyl 2-(4-chloropyriMidin-5-yl)acetate

5-Pyrimidineacetic acid, 4-chloro-, ethyl ester

2,4-Dichloro-3,5-dinitroaniline

6214-47-7

Heterocycle-Pyrimidine series