4-Chloro-5-pyrimidineacetic acid ethyl ester
- Product Name
- 4-Chloro-5-pyrimidineacetic acid ethyl ester
- CAS No.
- 6214-47-7
- Chemical Name
- 4-Chloro-5-pyrimidineacetic acid ethyl ester
- Synonyms
- 2,4-Dichloro-3,5-dinitroaniline;ethyl 2-(4-chloropyriMidin-5-yl)acetate;5-Pyrimidineacetic acid, 4-chloro-, ethyl ester;4-Chloro-5-pyrimidineacetic acid ethyl ester
- CBNumber
- CB22473895
- Molecular Formula
- C8H9ClN2O2
- Formula Weight
- 200.62
- MOL File
- 6214-47-7.mol
4-Chloro-5-pyrimidineacetic acid ethyl ester Property
- Boiling point:
- 95-96 °C(Press: 0.04 Torr)
- Density
- 1.276±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -0.25±0.16(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 6214477
- Product name
- Ethyl4-chloropyrimidine-5-acetate
- Packaging
- 250mg
- Price
- $211.89
- Updated
- 2021/12/16
- Product number
- CM123318
- Product name
- ethyl2-(4-chloropyrimidin-5-yl)acetate
- Purity
- 97%
- Packaging
- 1g
- Price
- $337
- Updated
- 2021/12/16
- Product number
- CD11088132
- Product name
- Ethyl2-(4-chloropyrimidin-5-yl)acetate
- Purity
- 97%
- Packaging
- 1g
- Price
- $356
- Updated
- 2021/12/16
- Product number
- 61-10223
- Product name
- Ethyl2-(4-chloropyrimidin-5-yl)acetate
- Purity
- 95-98%
- Packaging
- 1g
- Price
- $430
- Updated
- 2021/12/16
- Product number
- 6214477
- Product name
- Ethyl4-chloropyrimidine-5-acetate
- Packaging
- 1g
- Price
- $554.95
- Updated
- 2021/12/16
4-Chloro-5-pyrimidineacetic acid ethyl ester Chemical Properties,Usage,Production
Synthesis
6214-46-6
6214-47-7
Ethyl 2-(6-oxo-1,6-dihydropyrimidin-5-yl)acetate (1107) (0.868 g, 4.77 mmol) was mixed with phosphorus oxychloride (POCl3) (6 mL) under nitrogen protection and heated to reflux. The reaction was maintained for 5 min and then cooled to room temperature. The reaction mixture was slowly poured into water (300 mL) and the aqueous phase was extracted with dichloromethane (DCM) (3 x 100 mL). The organic phases were combined, washed with saturated saline (100 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the target compound 4-chloro-5-pyrimidine ethyl acetate (1108) (0.885 g, 93% yield) as a light yellow oil.1H NMR (400 MHz, CDCl3) δ 8.93 (s, 1H), 8.61 (s , 1H), 4.21 (q, J = 7.1 Hz, 2H), 3.76 (s, 2H), 1.28 (t, J = 7.1 Hz, 3H).LCMS method C: retention time 5.09 min; m/z 201.0, 203.1 [M+H]+.
References
[1] Patent: WO2012/110773, 2012, A1. Location in patent: Page/Page column 130; 132
[2] Patent: WO2014/27199, 2014, A1. Location in patent: Page/Page column 134
4-Chloro-5-pyrimidineacetic acid ethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
4-Chloro-5-pyrimidineacetic acid ethyl ester Suppliers
- Tel
- --
- Fax
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- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
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View Lastest Price from 4-Chloro-5-pyrimidineacetic acid ethyl ester manufacturers
- Product
- 4-Chloro-5-pyrimidineacetic acid ethyl ester 6214-47-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2025-08-22
- Product
- 4-Chloro-5-pyrimidineacetic acid ethyl ester 6214-47-7
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-10