2-Amino-5-bromo-3-(hydroxymethyl)pyridine
- Product Name
- 2-Amino-5-bromo-3-(hydroxymethyl)pyridine
- CAS No.
- 335031-01-1
- Chemical Name
- 2-Amino-5-bromo-3-(hydroxymethyl)pyridine
- Synonyms
- 2-broMo-4-ethoxypyriMidine;2-Amino-5-Bromo-3-(Hydroxymeth;2-Amino-5-bromopyridine-3-methanol;2-Amino-5-bromo-3-pyridinemethanol;3-Pyridinemethanol, 2-amino-5-bromo-;(2-AMINO-5-BROMO-3-PYRIDINYL)METHANOL;2-AMino-3-hydroxyMethyl-5-broMopyridine;(2-AMINO-5-BROMO-PYRIDIN-3-YL)-METHANOL;2-AMino-5-broMo-3-pyridineMethanol, 98+%;2-Amino-5-bromo-3-(hydroxymethyl)pyridine
- CBNumber
- CB2248055
- Molecular Formula
- C6H7BrN2O
- Formula Weight
- 203.04
- MOL File
- 335031-01-1.mol
2-Amino-5-bromo-3-(hydroxymethyl)pyridine Property
- Melting point:
- 137-140°C
- Boiling point:
- 343.5±37.0 °C(Predicted)
- Density
- 1.766±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Acetone, Ethyl Acetate, Methanol
- pka
- 13.16±0.10(Predicted)
- form
- Solid
- color
- Off-white to yellow
- InChI
- InChI=1S/C6H7BrN2O/c7-5-1-4(3-10)6(8)9-2-5/h1-2,10H,3H2,(H2,8,9)
- InChIKey
- HIVQAWXDBPYNDU-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=C(Br)C=C1CO
- CAS DataBase Reference
- 335031-01-1(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- HazardClass
- IRRITANT
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- A601850
- Product name
- 2-Amino-5-bromo-3-pyridinemethanol
- Packaging
- 2g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-W003239
- Product name
- 2-Amino-5-bromo-3-(hydroxymethyl)pyridine
- Purity
- >98.0%
- Packaging
- 10g
- Price
- $122
- Updated
- 2021/12/16
- Product number
- FA17611
- Product name
- 2-Amino-5-bromo-3-pyridinemethanol
- Packaging
- 500mg
- Price
- $135
- Updated
- 2021/12/16
- Product number
- CS-W003239
- Product name
- 2-Amino-5-bromo-3-(hydroxymethyl)pyridine
- Purity
- >98.0%
- Packaging
- 5g
- Price
- $68
- Updated
- 2021/12/16
- Product number
- FA17611
- Product name
- 2-Amino-5-bromo-3-pyridinemethanol
- Packaging
- 1g
- Price
- $236.2
- Updated
- 2021/12/16
2-Amino-5-bromo-3-(hydroxymethyl)pyridine Chemical Properties,Usage,Production
Uses
2-Amino-5-bromo-3-(hydroxymethyl)pyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
Synthesis
2-Amino-5-bromo-3-(hydroxymethyl)pyridineBromine (8.4 mL, 189.4 mmol) was added dropwise over 1 hour to a solution of 2- amino-3-(hydroxymethyl)pyridine (19.6 g, 157.8 mmol) in acetic acid (350 mL) at room temperature. The reaction mixture was then stirred overnight. After concentration to dryness, the residue was partitioned between a saturated solution of potassium carbonate (300 mL) and ethyl acetate (200 ml_). The aqueous layer was separated and extracted with ethyl acetate (2 x 200 ml_). The combined organic phases were washed with a saturated solution of sodium chloride (200 ml_), dried over sodium sulfate, filtered and concentrated to dryness. After trituration of the residue in pentane, the title product was obtained as a yellow solid (27.0 g, 84%).
References
[1] Patent: WO2011/61214, 2011, A1. Location in patent: Page/Page column 30-31
[2] Patent: EP1226138, 2004, B1
[3] Patent: US2004/53814, 2004, A1
[4] Journal of Medicinal Chemistry, 2003, vol. 46, # 9, p. 1627 - 1635
[5] Patent: CN108440523, 2018, A. Location in patent: Paragraph 0028; 0030
2-Amino-5-bromo-3-(hydroxymethyl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-5-bromo-3-(hydroxymethyl)pyridine manufacturers
- Product
- 2-Amino-5-bromo-3-(hydroxymethyl)pyridine 335031-01-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-25
- Product
- 2-Amino-5-bromo-3-(hydroxymethyl)pyridine 335031-01-1
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11