PIK-93

ChemicalBook > CAS DataBase List > PIK-93

Description Features In vitro

Product Name: PIK-93
CAS No.: 593960-11-3
Chemical Name: PIK-93
Synonyms: PI-93;PIK 93;CS-426;PIK-93,PIK93;Shokat PI3K/PIK-93;PIK-93;PIK 93;PIK93;PI 3,4-K inhibitor, PIK-93;PI 3-4-K inhibitor PIK-93 PIK93;PI 3,4-K inhibitor, PIK-93 - CAS 593960-11-3 - Calbiochem;N-[5-[4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl]-4-methylthiazol-2-yl]acetamide
CBNumber: CB22484673
Molecular Formula: C14H16ClN3O4S2
Formula Weight: 389.88
MOL File: 593960-11-3.mol

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PIK-93 Property

storage temp.: 2-8°C
solubility: DMSO: soluble15mg/mL, clear
form: powder
color: white to beige
InChIKey: JFVNFXCESCXMBC-UHFFFAOYSA-N
CAS DataBase Reference: 593960-11-3

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0546
Product name: PIK93
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $123
Updated: 2024/03/01

Sigma-Aldrich

Product number: 528122
Product name: PI 3,4-K inhibitor, PIK-93
Packaging: 5mg
Price: $335
Updated: 2023/01/07

Cayman Chemical

Product number: 10009212
Product name: PIK-93
Purity: ≥98%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 10009212
Product name: PIK-93
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0546
Product name: PIK93
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $297.6
Updated: 2024/03/01

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PIK-93 Chemical Properties,Usage,Production

Description

PIK-93 is the first potent, synthetic PI4K (PI4KIIIβ) inhibitor with IC50 of 19 nM; shown to inhibit PI3Kα with IC50 of 39 nM.

Features

A novel and potent inhibitor of both PI3Kγ and PI4KIIIβ.

In vitro

PIK-93 inhibits PI3Kγ and PI4KIIIβ, with IC50 values of 16 nM and 19 nM, respectively. PIK-93 also inhibits other members of PI3Ks, including PI3Kα, β, and δ, with IC50 values of 39 nM, 0.59 μM, and 0.12 μM, respectively. PIK-93 shows no obvious inhibitory effect against a panel of other kinases, even at a concentration of 10 μM. In differentiated HL60 (dHL60) cells, PIK-93 (0.5 μM–1 μM) impairs consolidation and stability of the leading edge formed after treatment with uniform f-Met-Leu-Phe (fMLP). PIK-93 alters the localization, but not the amount, of the fMLP-dependent accumulation of total F-actin. In fMLP gradients, PIK-93 reduces the chemotactic index and triples the cells' turning frequency. In COS-7 cells, PIK-93 (250 nM) effectively abrogates the accumulation of CERT-PH domain and FL-Cer in Golgi. PIK-93 of the same concentration also significantly inhibits the conversion of [3H]serine-labeled endogenous ceramide to sphingomyelin. These facts indicate a key role of PI4KIIIβ in ceramide transport between the ER and Golgi, as well as in the regulation of spingomyelin synthesis. In T6.11 cells, PIK-93 (300 nM) reduces carbachol-induced translocation of TRPC6 to the plasma membrane and net Ca2+ entry. A recent report shows that PIK-93 has anti-enterovirus effects, as revealed by its inhibition of both poliovirus (PV) and hepatitis C virus (HCV) replication, with EC50 values of 0.14 µM and 1.9 µM, respectively.

Description

PIK-93 is an inhibitor of phosphatidylinositol 4-kinase IIIβ (PI4KIIIβ; IC₅₀ = 19 nM). It is selective for PI4KIIIβ over PI4KIIIα and PI4KIIα (IC₅₀s = 1,100 and >100,000 nM, respectively). However, it also inhibits the PI3K catalytic subunits (IC₅₀s = 39, 590, 120, and 16 nM for p110α, p110β, p110δ, and p110γ, respectively). PIK-93 reduces enteroviral RNA replication when used at a concentration of 125 nM in HeLa cells. It also inhibits the transport of ceramide from the endoplasmic reticulum to the Golgi apparatus.

Uses

PIK 93 is a PI3Kγ and PI4KIIIβ inhibitor.

Enzyme inhibitor

This potent and selective PI3Kγ/PI4KIIIβ inhibitor (FW = 389.88; CAS 593960-11-3; Solubility (25°C): 78 mg/mL DMSO, <1 mg/mL Water), also known as N-[5-[4-chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl]-4- methylthiazol-2-yl]acetamide, impairs actin filament consolidation and stability at the leading edge in cells treated with N-formyl-Met-Leu-Phe as well as ceramide transport between ER and Golgi compartments. The inhibition of PI3K by PIK-93, LY294002, or wortmannin decreased carbachol-induced translocation of TRPC6 to the plasma membrane and carbachol-induced net Ca2+ entry into T6.11 cells. PIK-93 inhibits both poliovirus (PV) and hepatitis C virus (HCV) replication, with EC50 values of 0.14 μM and 1.9 μM, respectively. Targets: PI3Kγ, IC50 = 16 nM; PI4KIIIβ, IC50 = 19 nM; PI3Kα, IC50 = 39 nM; PI3Kδ, IC50 = 0.12 μM; and PI3Kβ, IC50 = 0.59 μM.

target

PI3Kγ

References

[1] monet m, francoeur n, boulay g. involvement of phosphoinositide 3-kinase and pten protein in mechanism of activation of trpc6 protein in vascular smooth muscle cells. j biol chem. 2012 may 18;287(21):17672-81.
[2] tóth b, balla a, ma h et al. phosphatidylinositol 4-kinase iiibeta regulates the transport of ceramide between the endoplasmic reticulum and golgi. j biol chem. 2006 nov 24;281(47):36369-77.
[3] hsu, n. y., et al. 2010. viral reorganization of the secretory pathway generates distinct organelles for rna replication. cell 141:799-811.
[4] arita m, kojima h, nagano t et al. phosphatidylinositol 4-kinase iii beta is a target of enviroxime-like compounds for antipoliovirus activity. j virol. 2011 mar;85(5):2364-72.

PIK-93 Preparation Products And Raw materials

Raw materials

Preparation Products

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PIK-93 Suppliers

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View Lastest Price from PIK-93 manufacturers

Career Henan Chemical Co

Product: N-[5-[4-Chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]acetamide 593960-11-3
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-23

593960-11-3, PIK-93Related Search:

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N-[5-[4-Chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]acetamide

PIK 93

PI-93

AcetaMide, N-[5-[4-chloro-3-[[(2-hydroxyethyl)aMino]sulfonyl]phenyl]-4-Methyl-2-thiazolyl]-

PIK-93,PIK93

N-[5-[4-Chloro-3-[(2-hydroxyethyl)sulfamoyl]phenyl]-4-methylthiazol-2-yl]acetamide

N-[5-[4-Chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]acetamide PIK 93

PIK 93 N-[5-[4-Chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]acetamide

N-(5-(4-Chloro-3-(N-(2-hydroxyethyl)sulfamoyl)phenyl)-4-methylthiazol-2-yl)acetamide

PI 3,4-K inhibitor, PIK-93

PI 3,4-K inhibitor, PIK-93 - CAS 593960-11-3 - Calbiochem

PIK-93;PIK 93;PIK93

N-[5-[4-Chloro-3-[[(2-hydroxyethyl)amino]sulfonyl]phenyl]-4-methyl-2-thiazoly]acetamide

CS-426

Shokat PI3K/PIK-93

PI 3-4-K inhibitor PIK-93 PIK93

PI4K,Phosphatidylinositol 4 kinases,PI4 kinases,Phosphoinositide 3-kinase,inhibit,Inhibitor,Virus Protease,PIK93,PIK-93,PI3K

N-[5-[4-chloro-3-(2-hydroxyethylsulfamoyl)phenyl]-4-methyl-1,3-thiazol-2-yl]acetamide

593960-11-3

Inhibitors

Akt

mTOR

PI3K