3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer
- Product Name
- 3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer
- CAS No.
- 26680-10-4
- Chemical Name
- 3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer
- Synonyms
- Lactide polymer;RESOMER? R 202 H;RESOMER? R 203 S;RESOMER? R 202 S;RESOMER? R 203 H;RESOMER(R) R 203 S;RESOMER(R) R 202 S;RESOMER(R) R 202 H;RESOMER(R) R 203 H;Resomer R 207 S, Poly(D,L-lactide)
- CBNumber
- CB22490072
- Molecular Formula
- C6H8O4
- Formula Weight
- 144.12532
- MOL File
- 26680-10-4.mol
3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer Property
- Melting point:
- 215 °C
- Density
- 1.23 g/cm3
- Flash point:
- 113°C
- storage temp.
- 2-8°C
- solubility
- Soluble in dichloromethane, tetrahydrofuran, ethyl acetate, chloroform, hexafluoroisopropanol, and acetone. Insoluble in water.
- form
- solid
Safety
- WGK Germany
- nwg
N-Bromosuccinimide Price
- Product number
- 719943
- Product name
- Poly(D,L-lactide)
- Purity
- acid terminated, Mw 18,000-24,000
- Packaging
- 5g
- Price
- $323
- Updated
- 2024/03/01
- Product number
- 769835
- Product name
- Resomer® R 205 S, Poly(D,L-lactide)
- Purity
- ester terminated
- Packaging
- 1G
- Price
- $89.9
- Updated
- 2023/06/20
- Product number
- 769835
- Product name
- Resomer® R 205 S, Poly(D,L-lactide)
- Purity
- ester terminated
- Packaging
- 5G
- Price
- $284
- Updated
- 2023/06/20
- Product number
- 719943
- Product name
- Poly(D,L-lactide)
- Purity
- acid terminated, Mw 18,000-24,000
- Packaging
- 1g
- Price
- $96.1
- Updated
- 2023/06/20
- Product number
- 805734
- Product name
- Poly(D,L-lactide)
- Purity
- acid terminated, average Mw 15000
- Packaging
- 5g
- Price
- $329
- Updated
- 2024/03/01
3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer Chemical Properties,Usage,Production
Chemical Properties
Poly(DL-lactic acid) is a glassy material, occurring as white to golden-yellow pellets or granules.
Uses
May be used to make drug delivery materials for controlled release.
Definition
ChEBI: Lactide is a member of dioxanes.
Production Methods
Lactic acid is a chiral molecule and has two optically active forms: Llactic acid and D-lactic acid. Poly(DL-lactic acid) is produced from the racemic mixture of lactic acid. Lactic acid is produced either from ethylene (petrochemical pathway) or by bacterial fermentation of D-glucose derived from food stocks. The former pathway involves an oxidation step followed by treatment with hydrogen cyanide and produces only racemic DL-lactic acid. In contrast, lactic acid produced by fermentation occurs mainly as L-lactic acid. Lowmolecular- weight poly-DL-(lactic acid) (500–10 000 Da) is produced directly from lactic acid by condensation. Higher-molecular-weight product is produced by one of two major pathways. The first involves a depolymerization of low-molecular-weight polymer into the cyclic dimer form (lactide) followed by ring-opening polymerization. Alternatively, it can be produced by a direct condensation using azeotropic distillation.
General Description
Resomer? R 207 S, Poly(D,L-lactide) (PDLLA), a biodegradable and biocompatible polymer, can be used for a variety of biological applications. It shows properties like long degradation time, mechanical stiffness and hydrophobicity.
Pharmaceutical Applications
Poly(DL-lactic acid) is used in drug delivery systems in implants, injections, and oral solid dispersions. It is also used as a coating agent.
Safety
Poly(DL-lactic acid) degrades to produce lactic acid, which is considered a well-tolerated nontoxic material. Several in vitro and in vivo studies demonstrated that poly(lactic acid) in general (including poly(DL-lactic acid)) is well tolerated and does not induce a significant immune response.However, some studies have illustrated signs of a mild immune response.The FDA has also reported some rare cases of inflammatory responses in patients treated with cosmetic poly(DL-lactic acid) injections.
storage
Poly(DL-lactic acid) is stable under dry conditions. However, it typically biodegrades over a period of 10–15 months according to the molecular weight. Increasing moisture and temperature enhances biodegradation; the onset of degradation in water at 25°C is 6 months.In contrast to many other biodegradable polymers, poly(DL-lactic acid) degrades through a two-step mechanism. The primary degradation step involves the hydrolysis of the ester bonds independently of microbial activity to produce a low-molecular-weight polymer. When the molecular weight drops below 10 000, microorganisms digest the polymer into carbon dioxide and water. Poly(DL-lactic acid) is more stable than poly(L-lactic acid) or poly(D-lactic acid) alone.Poly(DL-lactic acid) should be stored in a dry inert environment at a temperature of －15°C to －20°C.
Incompatibilities
Incompatible with strong acids or alkaline materials.
Regulatory Status
Included in the FDA Inactive Ingredients Database (IM, powder, for injection, suspension, and lyophilization). Poly(DL-lactic acid) is considered as ‘not hazardous’ according to the European Directive 67/548/EEC. Included in parenteral preparations (prolongedrelease powder for suspension for subcutaneous or intramuscular injection) licensed in the UK.
3,6-Dimethyl-1,4-dioxane-2,5-dione homopolymer Preparation Products And Raw materials
Raw materials
Preparation Products
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