ethyl 1-acetylcyclopropanecarboxylate
- Product Name
- ethyl 1-acetylcyclopropanecarboxylate
- CAS No.
- 32933-03-2
- Chemical Name
- ethyl 1-acetylcyclopropanecarboxylate
- Synonyms
- thyl 1-acetylcyclopropanecarboxylate;Ethyl 1-acetylcyclopropan-carboxylate;ethyl 1-acetylcyclopropanecarboxylate;Ethyl 1-acetylcyclopropane-1-carboxylate;1-Acetylcyclopropancarbonsaeure-ethylester;1-Acetyl-cyclopropanecarboxylic acid ethyl ester;1-acetyl-1-cyclopropanecarboxylic acid ethyl ester;Cyclopropanecarboxylic acid, 1-acetyl-, ethyl ester;1-acetyl-Cyclopropanecarboxylic acid ethyl ester (8CI 9CI ACI);Cyclopropanecarboxylic acid, 1-acetyl-, ethyl ester (8CI, 9CI, ACI)
- CBNumber
- CB22499747
- Molecular Formula
- C8H12O3
- Formula Weight
- 156.18
- MOL File
- 32933-03-2.mol
ethyl 1-acetylcyclopropanecarboxylate Property
- Boiling point:
- 42-44 °C(Press: 2 Torr)
- Density
- 1.139±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- Appearance
- Colorless to light yellow Liquid
- InChI
- InChI=1S/C8H12O3/c1-3-11-7(10)8(4-5-8)6(2)9/h3-5H2,1-2H3
- InChIKey
- DISZFIFAESWGBI-UHFFFAOYSA-N
- SMILES
- C1(C(C)=O)(C(OCC)=O)CC1
Safety
- HS Code
- 2902190000
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- PH018197
- Product name
- (3-Oxocyclohexyl)acetic acid
- Purity
- AldrichCPR
- Packaging
- 1G
- Price
- $201
- Updated
- 2023/06/20
- Product number
- E1442
- Product name
- Ethyl 1-Acetylcyclopropane-1-carboxylate
- Purity
- min. 98.0 %
- Packaging
- 1G
- Price
- $94
- Updated
- 2025/07/31
- Product number
- E1442
- Product name
- Ethyl 1-Acetylcyclopropane-1-carboxylate
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $284
- Updated
- 2025/07/31
- Product number
- E896430
- Product name
- Ethyl1-acetylcyclopropanecarboxylate
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 077028
- Product name
- Ethyl 1-acetylcyclopropane-1-carboxylate
- Purity
- >95%
- Packaging
- 500mg
- Price
- $74
- Updated
- 2021/12/16
ethyl 1-acetylcyclopropanecarboxylate Chemical Properties,Usage,Production
Uses
ethyl 1-methyl cyclopropanecarboxylate is an important pharmaceutical intermediate used in the addition of cyclopropane.
Synthesis
141-97-9
106-93-4
32933-03-2
Step 1) Synthesis of ethyl 1-acetylcyclopropanecarboxylate: To a solution of ethyl 3-oxobutanoate (26 g, 200 mmol) in acetone (500 mL) was added potassium carbonate (82.8 g, 600 mmol) followed by 1,2-dibromoethane (45.12 g, 240 mmol). The reaction mixture was refluxed for 24 hours. After completion of the reaction, the mixture was filtered and the filtrate was concentrated under vacuum. The residue was purified by silica gel column chromatography with an eluent ratio of 1:50 (v/v) ethyl acetate/hexane to afford the target compound ethyl 1-acetylcyclopropanecarboxylate as a colorless oil (18.7 g, 60% yield). Mass spectrum (ESI, cation mode) m/z: 157 (M+1); 1H NMR (400 MHz, CDCl3) δ: 1.25-1.29 (t, J=7.2 Hz, 3H), 1.45 (s, 4H), 2.45 (s, 3H), 4.18-4.20 (q, 2H).
References
[1] Tetrahedron Letters, 2005, vol. 46, # 4, p. 635 - 638
[2] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2004, vol. 43, # 2, p. 420 - 422
[3] Tetrahedron Asymmetry, 2010, vol. 21, # 5, p. 631 - 635
[4] Journal of Organic Chemistry, 2011, vol. 76, # 8, p. 2807 - 2813
[5] Chemistry of Heterocyclic Compounds (New York, NY, United States), 1983, vol. 19, # 6, p. 644 - 650
ethyl 1-acetylcyclopropanecarboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from ethyl 1-acetylcyclopropanecarboxylate manufacturers
- Product
- ethyl 1-acetylcyclopropanecarboxylate 32933-03-2
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2 MTs
- Release date
- 2024-08-06
- Product
- ethyl 1-acetylcyclopropanecarboxylate 32933-03-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2024-08-13
- Product
- ethyl 1-acetylcyclopropanecarboxylate 32933-03-2
- Price
- US $6.68/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-08