ChemicalBook > CAS DataBase List > 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

Product Name: 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
CAS No.: 924296-39-9
Chemical Name: 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile
Synonyms: CS-1900;HBX 41108;HBX 41108;HBX-41108;7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile;7-chloro-5-oxo-5H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile;9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 7-chloro-9-oxo-;DUBs,inhibit,HBX 41108,Apoptosis,Deubiquitinase,Inhibitor,HBX41108;7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile HBX 41108
CBNumber: CB22504744
Molecular Formula: C13H3ClN4O
Formula Weight: 266.64
MOL File: 924296-39-9.mol

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7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile Property

Melting point:: 220(dec.)℃
Boiling point:: 604.9±55.0 °C(Predicted)
Density: 1.66
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥1.83 mg/mL in EtOH with gentle warming and ultrasonic; ≥13.35 mg/mL in DMSO
form: solid
pka: -9.42±0.20(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3415
Product name: HBX 41,108
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $62.94
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML3415
Product name: HBX 41,108
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $268
Updated: 2025/07/31

Cayman Chemical

Product number: 23759
Product name: HBX 41108
Purity: ≥95%
Packaging: 1mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 23759
Product name: HBX 41108
Purity: ≥95%
Packaging: 5mg
Price: $161
Updated: 2024/03/01

Cayman Chemical

Product number: 23759
Product name: HBX 41108
Purity: ≥95%
Packaging: 10mg
Price: $266
Updated: 2024/03/01

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7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile Chemical Properties,Usage,Production

Uses

7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile is used in the synthesis and biological evaluation of 9-Oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential Inhibitors of deubiquitinating enzymes.

Biological Activity

hbx 41108 is a potent inhibitor of usp7 with ic50 value of 424 nm [1].ubiquitin-specific-processing protease 7 (usp7) is a ubiquitin specific protease and removes ubiquitin from specific protein substrates. usp7 can deubiquitinate p53, protecting p53 from mdm2-mediated degradation and involving the oncogenic stabilization of p53.hbx 41108 is an uncompetitive and reversible usp7 inhibitor. hbx 41108 inhibited usp7-mediated p53 deubiquitination with ic50 value of 0.8 μm in a dose-dependent way and was only weakly active against the aspartic, serine and metalloproteases tested with ic50 > 10 μm. in hct116 cells, hbx 41108 increased the levels of p53 and p21cip1/waf, which was the product of p53 target genes. in hek293 cells, hbx 41108 increased the level of polyubiquitinated forms of p53 and reduced mdm2 levels. in hct116 colon cancer cells, hbx 41108 inhibited cell proliferation with ic50 value of 1 μm in a dose-dependent way and induced apoptosis in a dose-dependent manner [1]. in cos7 cells, hbx 41108 inhibited pparγ stability induced by usp7 and decreased the basal transcriptional activity of pparγ by 70% [2].

in vivo

HBX 41108 (100 mg/kg/day for 14 days, i.p.) can promote wound healing and reduce blood sugar levels in diabetic rats ^[3].

IC 50

USP7: 424 nM (IC₅₀); hTPH2

storage

Store at -20°C

References

[1]. colland f, formstecher e, jacq x, et al. small-molecule inhibitor of usp7/hausp ubiquitin protease stabilizes and activates p53 in cells. mol cancer ther, 2009, 8(8): 2286-2295.
[2]. lee kw, cho jg, kim cm, et al. herpesvirus-associated ubiquitin-specific protease (hausp) modulates peroxisome proliferator-activated receptor γ (pparγ) stability through its deubiquitinating activity. j biol chem, 2013, 288(46): 32886-32896.

7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile manufacturers

Career Henan Chemical Co

Product: 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile 924296-39-9
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-13

924296-39-9, 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrileRelated Search:

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7-chloro-5-oxo-5H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile HBX 41108

CS-1900

HBX 41108;HBX-41108

DUBs,inhibit,HBX 41108,Apoptosis,Deubiquitinase,Inhibitor,HBX41108

9H-Indeno[1,2-b]pyrazine-2,3-dicarbonitrile, 7-chloro-9-oxo-

924296-39-9

C13H3ClN4O

Amines

Heterocycles

Inhibitors

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