α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol
- Product Name
- α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol
- CAS No.
- 176721-01-0
- Chemical Name
- α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol
- Synonyms
- Dexmedetomidine Impurity 28;α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methan;(2,3-diMethylphenyl)(1-trityl-1H-iMidazol-4-yl)Methanol;(2,3-Dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanol;(2,3-Dimethylphenyl)-(3-trityl-3H-imidazol-4-yl)methanol;α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol;alpha-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol;alpha-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methano...;1-(2,3-dimethylphenyl)-1-(1H-imidazol-4-triphenylmethyl)methanol;α-(2,3-Dimethylphenyl)-1-(triphenylmethyl)-1H-imidazole-4-methanol
- CBNumber
- CB22508434
- Molecular Formula
- C31H28N2O
- Formula Weight
- 444.57
- MOL File
- 176721-01-0.mol
α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Property
- Melting point:
- 180 - 184°C
- Boiling point:
- 616.0±50.0 °C(Predicted)
- Density
- 1.09±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly, Heated)
- form
- Solid
- pka
- 13.08±0.20(Predicted)
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
H361Suspected of damaging fertility or the unborn child
H362May cause harm to breast-fed children
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P263Avoid contact during pregnancy/while nursing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D477340
- Product name
- α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol
- Packaging
- 250mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- FD22393
- Product name
- a-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- FD22393
- Product name
- a-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol
- Packaging
- 250mg
- Price
- $225
- Updated
- 2021/12/16
- Product number
- APN0000733
- Product name
- ALPHA-(2,3-DIMETHYLPHENYL)-1-(TRITYL)-1H-IMIDAZOLE-4-METHANOL
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $315
- Updated
- 2021/12/16
- Product number
- FD22393
- Product name
- a-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol
- Packaging
- 5G
- Price
- $320
- Updated
- 2021/12/16
α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol is an Intermediate in the production of Medetomidine
Synthesis
576-23-8
33016-47-6
176721-01-0
1. 11.5 g (60.2 mmol) of 1-bromo-2,3-dimethylbenzene was dissolved in 200 mL of anhydrous tetrahydrofuran (THF) in a dry reaction flask. 2. a mixed system consisting of 1.5 g (61.7 mmol) of magnesium strips, 0.05 g of iodine, and 50 mL of anhydrous THF was slowly added dropwise to initiate the preparation of Grignard's reagent. 3. After dropwise addition, the reaction system was heated to reflux and maintained at reflux for 1 hour to ensure complete reaction. 4. After completion of the reaction, the system was cooled to room temperature to obtain a solution of 2,3-dimethylphenylmagnesium bromide Grignard reagent. 5. In another dry reaction flask, 17.5 g (50.2 mmol) of 1-tritylimidazole-4-carbaldehyde was dissolved in 225 mL of anhydrous THF and this solution was cooled to 0 °C. The reaction was carried out at 0 °C. 6. The Grignard reagent solution prepared in step 4 was slowly added to the aldehyde solution at 0 °C, with controlled drop acceleration to maintain the reaction temperature. 7. After the addition is complete, the reaction mixture is stirred at room temperature for 1.5 hours to complete the nucleophilic addition reaction. 8. The reaction was quenched using saturated aqueous ammonium chloride solution and then most of the THF was removed by concentration under reduced pressure. 9. The organic phase was dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give the crude product. 10. The crude product was dissolved in dichloromethane and after removing most of the solvent by concentration under reduced pressure, the residue was cooled to -5 °C and kept for 1 hour to promote crystallization. 11. The crystals were collected by filtration, washed with cold dichloromethane and dried to give 12.4 g of (2,3-dimethylphenyl)(1-trityl-1H-imidazol-5-yl)methanol in 53.9% yield.
References
[1] Patent: CN108147999, 2018, A. Location in patent: Paragraph 0162; 0163
[2] Synthetic Communications, 1996, vol. 26, # 8, p. 1585 - 1593
[3] Journal of the Iranian Chemical Society, 2017, vol. 14, # 8, p. 1735 - 1739
α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol manufacturers
- Product
- α-(2,3-Dimethylphenyl)-1-(trityl)-1H-imidazole-4-methanol 176721-01-0
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-02-21