2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Product Name: 2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS No.: 960067-33-8
Chemical Name: 2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Synonyms: 2-(Difluoromethoxy)benzeneboronicacid,pinacolester;2-Difluoromethoxyphenylboronic acid, pinacol ester;2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;1,3,2-Dioxaborolane, 2-[2-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-;3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (2-(difluoromethoxy)phenyl)boronate;2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane - [D57058]
CBNumber: CB22513104
Molecular Formula: C13H17BF2O3
Formula Weight: 270.08
MOL File: 960067-33-8.mol

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2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Property

Boiling point:: 326.5±37.0 °C(Predicted)
Density: 1.13±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Store in freezer, under -20°C
form: solid
color: Orange

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Safety

HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D447553
Product name: 2-DifluoromethoxyphenylboronicAcid,PinacolEster
Packaging: 2.5g
Price: $710
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD103354
Product name: 2-Difluoromethoxyphenylboronic acid pinacol ester
Packaging: 50mg
Price: $100
Updated: 2021/12/16

Apolloscientific

Product number: PC48609
Product name: 2-(Difluoromethoxy)benzeneboronicacid,pinacolester
Packaging: 250mg
Price: $137
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD103354
Product name: 2-Difluoromethoxyphenylboronic acid pinacol ester
Packaging: 100mg
Price: $165
Updated: 2021/12/16

SynQuest Laboratories

Product number: 6660-3-73
Product name: 2-(Difluoromethoxy)benzeneboronic acid, pinacol ester
Packaging: 250mg
Price: $165
Updated: 2021/12/16

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2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Chemical Properties,Usage,Production

Uses

2-Difluoromethoxyphenylboronic Acid, Pinacol Ester is an intermediate in preparation of pyridine derivatives as voltage-gated sodium channel modulators useful in the treatment of pain.

Synthesis

175278-33-8

73183-34-3

960067-33-8

The general procedure for the synthesis of 2-difluoromethoxyphenylboronic acid pinacol ester from o-bromodifluoromethoxybenzene and bis(pinacolato)diboron (1.71 g, 6.75 mmol) was carried out as follows: o-bromodifluoromethoxybenzene (1 g, 4.5 mmol) and bis(pinacolato)diboron (1.71 g, 6.75 mmol) were dissolved in dioxane (10 mL), and followed by addition of anhydrous potassium acetate (1.1 g, 13.53 mmol ) and [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium dichloromethane complex (369 mg, 0.45 mmol). The reaction mixture was heated to 85 °C under nitrogen protection and stirred continuously for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure. The residue was purified by silica gel column chromatography with an eluent ratio of petroleum ether: ethyl acetate = 10:1, resulting in the light yellow oily product 2-difluoromethoxyphenylboronic acid pinacol ester (1.1 g, 90.2% yield).

References

[1] Patent: US2018/208604, 2018, A1. Location in patent: Paragraph 0216-0217
[2] Patent: WO2008/135826, 2008, A2. Location in patent: Page/Page column 156; 157

2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane manufacturers

Career Henan Chemical Co

Product: 2-[2-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 960067-33-8
Price: US $1.00/g
Min. Order: 1g
Purity: Min98%HPLC
Supply Ability: g/kg/ton
Release date: 2020-01-09

960067-33-8, 2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneRelated Search:

Phenylboronic acid

2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-Difluoromethoxyphenylboronic acid, pinacol ester

3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (2-(difluoromethoxy)phenyl)boronate

2-(Difluoromethoxy)benzeneboronicacid,pinacolester

1,3,2-Dioxaborolane, 2-[2-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-

2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane - [D57058]

960067-33-8