ChemicalBook > CAS DataBase List > 2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Product Name
2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS No.
960067-33-8
Chemical Name
2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
Synonyms
2-(Difluoromethoxy)benzeneboronicacid,pinacolester;2-Difluoromethoxyphenylboronic acid, pinacol ester;2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;1,3,2-Dioxaborolane, 2-[2-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-;3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (2-(difluoromethoxy)phenyl)boronate;2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane - [D57058]
CBNumber
CB22513104
Molecular Formula
C13H17BF2O3
Formula Weight
270.08
MOL File
960067-33-8.mol
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2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Property

Boiling point:
326.5±37.0 °C(Predicted)
Density 
1.13±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
form 
solid
color 
Orange
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Safety

HS Code 
2931900090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D447553
Product name
2-DifluoromethoxyphenylboronicAcid,PinacolEster
Packaging
2.5g
Price
$710
Updated
2021/12/16
Apolloscientific
Product number
PC48609
Product name
2-(Difluoromethoxy)benzeneboronicacid,pinacolester
Packaging
1g
Price
$325
Updated
2021/12/16
SynQuest Laboratories
Product number
6660-3-73
Product name
2-(Difluoromethoxy)benzeneboronic acid, pinacol ester
Packaging
1g
Price
$376
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD103354
Product name
2-Difluoromethoxyphenylboronic acid pinacol ester
Packaging
500mg
Price
$400
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
BOR0006133
Product name
2-(2-(DIFLUOROMETHOXY)PHENYL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE
Purity
95.00%
Packaging
1G
Price
$537.6
Updated
2021/12/16
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2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Chemical Properties,Usage,Production

Uses

2-Difluoromethoxyphenylboronic Acid, Pinacol Ester is an intermediate in preparation of pyridine derivatives as voltage-gated sodium channel modulators useful in the treatment of pain.

Synthesis

175278-33-8

73183-34-3

960067-33-8

The general procedure for the synthesis of 2-difluoromethoxyphenylboronic acid pinacol ester from o-bromodifluoromethoxybenzene and bis(pinacolato)diboron (1.71 g, 6.75 mmol) was carried out as follows: o-bromodifluoromethoxybenzene (1 g, 4.5 mmol) and bis(pinacolato)diboron (1.71 g, 6.75 mmol) were dissolved in dioxane (10 mL), and followed by addition of anhydrous potassium acetate (1.1 g, 13.53 mmol ) and [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium dichloromethane complex (369 mg, 0.45 mmol). The reaction mixture was heated to 85 °C under nitrogen protection and stirred continuously for 16 hours. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently concentrated under reduced pressure. The residue was purified by silica gel column chromatography with an eluent ratio of petroleum ether: ethyl acetate = 10:1, resulting in the light yellow oily product 2-difluoromethoxyphenylboronic acid pinacol ester (1.1 g, 90.2% yield).

References

[1] Patent: US2018/208604, 2018, A1. Location in patent: Paragraph 0216-0217
[2] Patent: WO2008/135826, 2008, A2. Location in patent: Page/Page column 156; 157

2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Preparation Products And Raw materials

Raw materials

Preparation Products

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2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Suppliers

China 40 India 1 United Kingdom 2 United States 6 Global 49
A.J Chemicals
Tel
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Fax
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Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from 2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane manufacturers

Career Henan Chemical Co
Product
2-[2-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 960067-33-8
Price
US $1.00/g
Min. Order
1g
Purity
Min98%HPLC
Supply Ability
g/kg/ton
Release date
2020-01-09

960067-33-8, 2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneRelated Search:

Phenylboronic acid

  • 2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  • 2-Difluoromethoxyphenylboronic acid, pinacol ester
  • 3-hydroxy-2,3-dimethylbutan-2-yl hydrogen (2-(difluoromethoxy)phenyl)boronate
  • 2-(Difluoromethoxy)benzeneboronicacid,pinacolester
  • 1,3,2-Dioxaborolane, 2-[2-(difluoromethoxy)phenyl]-4,4,5,5-tetramethyl-
  • 2-(2-(Difluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane - [D57058]
  • 960067-33-8