4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER

Product Name: 4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER
CAS No.: 461699-81-0
Chemical Name: 4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER
Synonyms: 4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER;4-Amino-3-methoxybenzeneboronicacid,pinacolester98%;4-Amino-3-methoxybenzeneboronic acid. pinacol ester;4-Amino-3-methoxybenzeneboronic acid, pinacol ester 98%;4-Amino-3-methoxybenzeneboronic acid,pinacol ester ,97%;2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);4'-METHYL4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER;2-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ANILINE;2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine;Benzenamine, 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber: CB2251796
Molecular Formula: C13H20BNO3
Formula Weight: 249.11
MOL File: 461699-81-0.mol

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4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER Property

Melting point:: 113-116°C
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
color: Light brown to brown

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2931900090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BML00087
Product name: 4-Amino-3-methoxyphenylboronic acid, pinacol ester
Purity: Aldrich
Packaging: 1g
Price: $286
Updated: 2025/07/31

TRC

Product number: A628010
Product name: 4-Amino-3-methoxyphenylboronic acid, pinacol ester
Packaging: 250mg
Price: $75
Updated: 2021/12/16

TRC

Product number: A628010
Product name: 4-Amino-3-methoxyphenylboronic acid, pinacol ester
Packaging: 1g
Price: $170
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA160570
Product name: 4-Amino-3-methoxyphenylboronic acid, pinacol ester
Packaging: 1g
Price: $180
Updated: 2021/12/16

AK Scientific

Product number: X0818
Product name: 4-Amino-3-methoxyphenylboronic acid, pinacol ester
Packaging: 10g
Price: $776
Updated: 2021/12/16

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4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER Chemical Properties,Usage,Production

Synthesis

262433-02-3

461699-81-0

General procedure for the synthesis of 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-trioxaborolan-2-yl)aniline from 4-(tert-butyloxycarbonylamino)-3-methoxyphenylboronic acid pinacol ester: 4-(tert-butyloxycarbonylamino)-3-methoxyphenylboronic acid pinacol ester (45.0 g, 0.129 mol) was dissolved in dichloromethane (270 mL). It was cooled in an ice bath until the temperature was below 5 °C. Subsequently, a 1:1 trifluoroacetic acid (TFA)/dichloromethane mixture (500 mL) was slowly added, while the reaction temperature was strictly controlled not to exceed 5 °C. Upon completion of the reaction, the mixture was gradually warmed up to room temperature and stirred continuously for 2 hours. At the end of the reaction, the solvent was removed by evaporation under reduced pressure (30 Torr) and a bath temperature of less than 30°C. The residue was re-dissolved in dichloromethane. The residue was redissolved in dichloromethane (250 mL) and washed carefully with 2.5N sodium hydroxide solution (300 mL). After separation of the organic layer, it was extracted with brine (100 mL) and subsequently dried over anhydrous magnesium sulfate, filtered and concentrated to afford the target product 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-trioxaborolan-2-yl)aniline (21.7 g, 68% yield). The product was confirmed by 1H NMR (DMSO-d6, 400MHz): δ 7.05 (d, 1H), 6.98 (d, 1H), 6.59 (d, 1H), 5.13 (s, 2H), 3.75 (s, 3H), 1.25 (s, 12H). Reversed-phase HPLC analysis conditions: Hypersil HS column (5 μm, 100?, 4.6 × 250 mm); mobile phase from 0% up to 100% acetonitrile/0.05 M ammonium acetate in 25 min, held for 10 min; flow rate 1 mL/min; retention time 11.03 min.

References

[1] Patent: US2005/20619, 2005, A1. Location in patent: Page 40-41
[2] Patent: US2005/43347, 2005, A1. Location in patent: Page/Page column 49
[3] Patent: US2002/156081, 2002, A1
[4] Patent: US6921763, 2005, B2

4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER Preparation Products And Raw materials

Raw materials

o-Anisidine N,N-Dimethylformamide [1,1'-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) Bis(pinacolato)diboron 2,4,6-Tribromophenol Bromine Dichloromethane Sodium hydroxide Potassium Acetate Magnesium sulfate

Preparation Products

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4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER Suppliers

China 62 Germany 2 India 1 Japan 1 United Kingdom 3 United States 8 Global 77

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View Lastest Price from 4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER manufacturers

Career Henan Chemical Co

Product: 4'-METHYL4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER 461699-81-0
Price: US $1.00/KG
Min. Order: 1KG
Purity: 97%-99.9%
Supply Ability: 100kg
Release date: 2019-12-23

461699-81-0, 4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTERRelated Search:

2-AMINOMETHYL-4-FLUOROPHENYLBORONIC ACID, HCL 2-AMINO-5-METHYLPHENYBORONIC ACID, PINACOL ESTER 3-AMINO-4-METHOXYPHENYLBORONIC ACID HCL (3-AMINO-5-METHOXYCARBONYL)BENZENEBORONIC ACID PINACOL ESTER HYDROCHLORIDE (2-Amino-4-methoxycarbonylphenyl)boronic acid pinacol ester hydrochloride (2-AMINO-4-METHOXYCARBONYLPHENYL)BORONIC ACID HYDROCHLORIDE 3-AMINO-4-METHOXYPHENYLBORONIC ACID Methyl 3-Amino-5-boronobenzoate, pinacol ester 3-AMINO-5-METHOXYCARBONYLPHENYLBORONIC ACID, HCL 4-(3-ETHYLUREIDO)-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER 3-Methoxyphenylboronic Acid Pinacol Ester 4-Aminophenylboronic acid pinacol ester 4-METHYL-7-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-3,4-DIHYDRO-2H-1,4-BENZOXAZINE 4-(TERT-BUTOXYCARBONYLAMINO)-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER 4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER

4'-METHYL4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER

4-Amino-3-methoxybenzeneboronic acid, pinacol ester 98%

2-METHOXY-4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)ANILINE

4-AMINO-3-METHOXYPHENYLBORONIC ACID, PINACOL ESTER

4-Amino-3-methoxybenzeneboronic acid. pinacol ester

4-Amino-3-methoxybenzeneboronicacid,pinacolester98%

2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)

4-Amino-3-methoxybenzeneboronic acid,pinacol ester ,97%

2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline, 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)anisole

Benzenamine, 2-methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)phenol

2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine

461699-81-0