ChemicalBook > CAS DataBase List > Benzo[b]thiophene-2-carboxylic acid, 7-bromo-
Benzo[b]thiophene-2-carboxylic acid, 7-bromo-
- Product Name
- Benzo[b]thiophene-2-carboxylic acid, 7-bromo-
- CAS No.
- 19075-59-3
- Chemical Name
- Benzo[b]thiophene-2-carboxylic acid, 7-bromo-
- Synonyms
- 7-Bromobenzothiophene-2-carboxylic acid;7-Bromo-1-benzothiophene-2-carboxylic acid;7-broMo-Benzo[b]thiophene-2-carboxylic acid;Benzo[b]thiophene-2-carboxylic acid, 7-bromo-;7-Bromobenzo[b]thiophene-2-carboxylic acid 98%;7-Bromobenzo[b]thiophene-2-carboxylic acid 95+%;7-Bromo-2-carboxybenzo[b]thiophene, 7-Bromo-1-benzothiophene-2-carboxylic acid
- CBNumber
- CB22518558
- Molecular Formula
- C9H5BrO2S
- Formula Weight
- 257.1
- MOL File
- 19075-59-3.mol
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Benzo[b]thiophene-2-carboxylic acid, 7-bromo- Property
- storage temp.
- 2-8°C(protect from light)
- form
- solid
- color
- White
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Safety
- HazardClass
- IRRITANT
- HS Code
- 2916399090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- B680663
- Product name
- 7-Bromobenzothiophene-2-carboxylicacid
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
TRC
- Product number
- B680663
- Product name
- 7-Bromobenzothiophene-2-carboxylicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 6H21-9-10
- Product name
- 7-Bromobenzo[b]thiophene-2-carboxylic acid
- Purity
- 95.0%
- Packaging
- 1g
- Price
- $88
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-B0212
- Product name
- 7-Bromobenzo[b]thiophene-2-carboxylicacid
- Packaging
- 1g
- Price
- $71
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FB139377
- Product name
- 7-Bromobenzo[b]thiophene-2-carboxylic acid
- Packaging
- 1g
- Price
- $230
- Updated
- 2021/12/16
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Benzo[b]thiophene-2-carboxylic acid, 7-bromo- Chemical Properties,Usage,Production
Synthesis
550998-53-3
19075-59-3
General procedure for the synthesis of 7-bromobenzo[b]thiophene-2-carboxylic acid from methyl 7-bromobenzo[b]thiophene-2-carboxylate: 7-bromobenzo[b]thiophene-2-carboxylic acid methyl ester (64 mg, 0.22 mmol) was dissolved in methanol (3 mL), followed by addition of 3 N sodium hydroxide solution (240 μL, 0.72 mmol). The reaction mixture was heated to reflux for 2 hours. Upon completion of the reaction, the reaction mixture was acidified with 3 N hydrochloric acid and extracted with ethyl acetate (30 mL). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. 7-Bromobenzo[b]thiophene-2-carboxylic acid (62 mg, 0.24 mmol, 100% yield) was obtained as a white solid and did not require further purification by silica gel column chromatography.
References
[1] Patent: KR2015/117318, 2015, A. Location in patent: Paragraph 0181; 0192; 0193; 0194
[2] European Journal of Medicinal Chemistry, 2017, vol. 125, p. 538 - 550
[3] Patent: WO2003/104227, 2003, A1. Location in patent: Page 47, 48
[4] Patent: EP2926660, 2015, A1. Location in patent: Paragraph 0262; 0263
Benzo[b]thiophene-2-carboxylic acid, 7-bromo- Preparation Products And Raw materials
Raw materials
Preparation Products
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