PF-4708671

ChemicalBook > CAS DataBase List > PF-4708671

Product Name: PF-4708671
CAS No.: 1255517-76-0
Chemical Name: PF-4708671
Synonyms: CS-869;PF 4708671;PF-04708671;PF4708671/PF-4708671;PF-4708671 USP/EP/BP;PF 4708671 - PF 04708671;PF-4708671 PF4708671 S6 kinase inhibitor;2-[[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-6-(trifluoromethyl)-1H-benzimidazole;2-[[4-(5-ethyl-4-pyriMidinyl)-1-piperazinyl]Methyl]-6-(trifluoroMethyl)-1H-benziMidazole;1H-Benzimidazole, 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-
CBNumber: CB22518730
Molecular Formula: C19H21F3N6
Formula Weight: 390.41
MOL File: 1255517-76-0.mol

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PF-4708671 Property

Boiling point:: 572.8±50.0 °C(Predicted)
Density: 1.348±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: ≥20mg/mL
pka: 10.20±0.10(Predicted)
form: powder
color: off-white

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0143
Product name: PF-4708671
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $134
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0143
Product name: PF-4708671
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $545
Updated: 2024/03/01

Cayman Chemical

Product number: 15018
Product name: PF-04708671
Purity: ≥98%
Packaging: 10mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 15018
Product name: PF-04708671
Purity: ≥98%
Packaging: 25mg
Price: $218
Updated: 2024/03/01

Cayman Chemical

Product number: 15018
Product name: PF-04708671
Purity: ≥98%
Packaging: 50mg
Price: $412
Updated: 2024/03/01

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PF-4708671 Chemical Properties,Usage,Production

Chemical Properties

Pale purple Solid

Uses

PF-4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). PF-4708671 inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect on highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases.

Biological Activity

pf-4708671 is a cell-permeable and highly specific inhibitor of p70 ribosomal s6 kinase 1 with ic50 value of 160nm [1].s6k1 is a regulator of various biology processes. the inhibition of s6k1 is regard as a therapeutic for the treatment of cancer and insulin resistance. pf-4708671 is the first reported inhibitor of s6k1. it inhibits the activity of s6k1 in the in vitro assay with ki value of 20nm. for the isolated s6k1 from hek293 cell, pf-4708671 shows inhibition with ic50 value of 160nm. the inhibition of s6k1caused by pf-4708671 is much more potent than of other related kinases such as rsk2 and msk1. besides that, pf-4708671 prevents s6k1 from phosphorylating its substrates including the ribosomal s6 protein, mtor and rictor. in addition, pf-4708671 is found to enhance the phosphorylation of s6k1 at thr229 and thr389, results in a subsequent increase of s6k1 activity. whereas this increased activity is much less than that stimulated by igf1 [1].

Biochem/physiol Actions

PF-4708671 is a selective p70 ribosomal S6 kinase (S6K1) inhibitor. PF-4708671 inhibits S6K1 with a Ki of 20 nM and IC50 of 160 nM, while having no effect on the closely related RSK and MSK kinases.

Enzyme inhibitor

This cell-permeable protein kinase inhibitor (FW = 390.41 g/mol; CAS 1255517-76-0; Solubility = 30 mg/mL DMSO, <1 mg/mL H2O) targets p70 ribosomal S6 kinase (S6K1 isoform) with Ki of 20 nM and IC50 of 160 nM, without significant inhibition of S6K2 isoform or Akt1, Akt2, PKA, PKCα, PKC?, PRK2, ROCK2, RSK1, RSK2, or SGK1. PF-4708671 prevents the S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect upon the PMAinduced phosphorylation of substrates of the highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases.

storage

Store at +4°C

References

[1] pearce l, alton g, richter d, et al. characterization of pf-4708671, a novel and highly specific inhibitor of p70 ribosomal s6 kinase (s6k1). biochem. j, 2010, 431: 245-255.

PF-4708671 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from PF-4708671 manufacturers

Career Henan Chemical Co

Product: 2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole 1255517-76-0
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: ask
Release date: 2018-12-23

1255517-76-0, PF-4708671Related Search:

PF-562271 PF 573228 PF-05212384 PF-04691502 PF-562271HCl USP/EP/BP PF-04554878 Everolimus MK-2206 2HCl Alectinib AT7867 BI-D1870 Rapamycin

2-[[4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-5-(trifluoromethyl)-1H-benzo[d]imidazole

PF 4708671

PF4708671/PF-4708671

2-[[4-(5-ethyl-4-pyriMidinyl)-1-piperazinyl]Methyl]-6-(trifluoroMethyl)-1H-benziMidazole

PF-04708671

2-[[4-(5-ethylpyrimidin-4-yl)piperazin-1-yl]methyl]-6-(trifluoromethyl)-1H-benzimidazole

1H-Benzimidazole, 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-

2-[[4-(5-Ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-1H-benzimidazole PF-4708671

CS-869

PF 4708671 - PF 04708671

PF-4708671 USP/EP/BP

2-((4-(5-Ethylpyrimidin-4-yl)piperazin-1-yl)methyl)-6-(trifluoromethyl)-1H-benzo[d]imidazole

PF-4708671 PF4708671 S6 kinase inhibitor

1255517-76-0

C19H21F3N6

API

Akt

mTOR

PI3K

PI3K/Akt/mTOR

Amines

Aromatics

Heterocycles

Inhibitors

Intermediates & Fine Chemicals

Pfizer Compounds

Pharmaceuticals